血管心脏炎

Early light can be asymptomatic, but the heart murmur before the district will have an impact on children's education and employment, if untreated, will eventually lead to pulmonary hypertension, cardiomegaly, heart failure; some will be complicated by endocarditis, vascular embolization and high blood pressure, life-threatening.

轻者早期可无症状，但心前区杂音将影响患儿的升学和就业，若不进行治疗，最终会导致肺动脉高压、心脏扩大、心力衰竭；有的还会并发心内膜炎、血管栓塞和高血压等，危及生命。

Project Background and Conditions: The company started research new chemical products in 1998. After two years of efforts, a series of pharmaceutical intermediate sulfathiazole leave instructions, including : 3- methyl sulfathiazole leave instructions, 2- sulfathiazole leave instructions ethanoic acid, 2- acetyl sulfathiazole leave instructions, 2-thiofuran amino ethane ,2-thiofuran acetic, 3,4,5- tighter nitrobenzene have been successfully developed. 2-thiofuran amino ethane are the precursors raw materials of series antibiotic analgesic.

二、项目建设背景及条件：1998年公司开始研究开发高新精细化工产品，经过两年的努力，已成功研制出噻吩系列医药中间体，包括：3-甲基噻吩、2-噻吩乙酸、2-乙酰噻吩、2-噻吩乙胺、2-噻吩乙醇、3，4，5-三氯硝基苯等。2-噻吩乙胺系列噻吩产品使用于血小板及血栓有关的心脏血管病及消炎镇痛等如氯吡格雷、兴孢噻吩钠、兴孢西丁、噻吩洛酸等十几种新药的前体原料，是国家政策鼓励发展和有自主知识产权的项目。

rutaecarpine pharmacological effects and its related mechanism: rutaecarpine the heart positive inotropic, positive changes in the role and the heart protective effect, which with its promotion of calcitonin gene-related peptide release; rutaecarpine alkali have vasodilative and hypotensive effect, its mechanism mainly related to endothelial cells Ca2 +-NO-cGMP pathways and calcitonin gene-related peptide release; rutaecarpine to relax the anal sphincter, gastrointestinal motility inhibition of stress ulcer and ulcerative colitis have therapeutic effect; rutaecarpine on cerebral ischemia-reperfusion injury has a protective effect, which instead of increasing the concentration of calcitonin gene-related peptide-related; rutaecarpine inhibits platelet aggregation and arterial thrombosis; In addition, rutaecarpine Alkali also anti-inflammatory and analgesic, anti-tumor and other pharmacological effects.

综述了吴茱萸次碱的药理作用及其相关机制：吴茱萸次碱对心脏有正性肌力、正性变时作用和心脏保护作用，这与其促进降钙素基因相关肽释放有关；吴茱萸次碱有扩血管和降压作用，其机制主要涉及内皮细胞Ca2+-NO-cGMP途径和降钙素基因相关肽的释放；吴茱萸次碱能松弛肛门内括约肌，抑制胃肠运动，对应激性溃疡和溃疡性结肠炎也有治疗作用；吴茱萸次碱对脑缺血再灌注损伤有保护作用，这与其增加降钙素基因相关肽浓度有关；吴茱萸次碱能抑制血小板聚集和动脉血栓形成；此外，吴茱萸次碱还有抗炎镇痛、抗肿瘤等药理作用。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。