血管异位

Results There were 14 cases of tubal pregnancy (9 were located in ampullae ,4 were in interstitial trpes and 1 was in interstitial);And one cases were ovarian pregnancy.whose signs of CT were cystoid bump in the pelvic cavity,with uneven density and unclear interface with organization of surroundings, Cystoid wall or blood vessel of the part were intensified and there was no change inside the cystoid,concomitancy with hyperaemia of pelvic cavity.

结果 14例异位妊娠发生在输卵管(9例位于壶腹部，4例位于伞端，1例位于间质部)，1例发生在卵巢；CT表现盆腔囊实性肿块，密度高低不均，与周围组织分界不清，增强后囊壁强化或局部血管样强化而内部无强化，合并盆腔积血。

Those suggest that the two capsules both can control the growth of ectopica endometrium by regularing patients endocrine.At the same time,they both increase the activity of NK cells to reinforce the effect of getting rid of the ectopia endometrium.

这说明桂附胶囊和理气胶囊均能通过调节内分泌而抑制异位内膜的血管形成，从而抑制异位内膜的生长；同时增加NK细胞的活性，以加强对异位内膜组织的清除作用。

The results of experiment demonstrate:GuiFu and LiQi capsule can lower the content of ER and PR in ectopia endometrium;raise the activity of NK cells;restrain the generation of VEGF.

实验研究显示：桂附胶囊及理气胶囊能够降低子宫内膜异位症大鼠外周血中E2、P水平，降低异位内膜ER、PR的含量；提高NK细胞活性；抑制血管内皮生长因子的生成。

METHODS: Models of segmental heterotopic small intestine transplantation were established using three sleevelet vascular anastomosis.

采用三袖套血管吻合法建立大鼠节段性异位小肠移植模型。

Finally, sophisticated in io models, such as rodent models of peritoneal endometriosis as well as the chorioallantoic membrane assay and the dorsal skinfold chamber,allow for the detailed analysis of blood essel deelopment in ectopic endometrium and the efficacy of angiogenesis inhibitors.

最后，复杂的体内模型，例如腹膜的子宫内膜异位，绒毛膜尿囊膜分析和背部皮肤皱褶腔的啮鼠动物模型，在异位子宫内膜和血管生成抑制剂效用中考虑了血管发展的详细分析。

Results:(1) CBC possesses a natural trabecular structure. Its components is similar to the mineral of bone.(2) CBC has great cellur biocompatibility. It can promote cell adhesion, proliferation and secretory while needn t modification.(3) In nude mice, the ectopic osteogenesis of MCCAB was obvious which was better than that of CBC alone and the new bone formation increased in pace with time. In the MCCAB, both intramembranous and cartilaginous osteogeneses were seen but the former dominated.(4) When MCCAB was autotransplanted intramuscularly, the osteogenesis was much better than that of negative control groups.(5) The MCCAB can repair autogenous calvaria defects effectively and the effect was much better than that of CBM alone and blank group. Conclusion:(1) CBC possesses good biocompatibility, osteoconduction and porous structure, can be used as scaffold material for constructing of tissue engineering bone.

结果：(1)CBC具有天然的多孔网状结构，最大程度地保持了骨矿的微结构特征，可以作为骨组织工程的支架材料；(2)CBC细胞亲和性好，不需作修饰即能促进成骨细胞的粘附、增殖和分泌活动；(3)MSO/CBC复合人工骨在裸鼠皮下异位成骨作用明显，兼有膜内成骨和软骨内成骨的特点，成骨效果明显优于单纯CBC植入组；(4)MSO/CBC复合人工骨兔自体肌袋异位成骨作用明显，血管化充分，成骨效果明显优于单纯CBC植入组；(5)MSO/CBC复合人工骨修复兔颅骨临界性缺损效果好，明显优于单纯植入CBC组和空白对第四旱区大学硕士学位论文一照组，可以作为骨移植替代材料用于骨缺损畸形修复。

Estrogen can cause fetal congenital heart defects, large vascular malformation, hydrocephalus, cerebral meningocele, visceral malformations, hydrocephalus, meningeal, bulging, visceral malformations, feminization of male fetus, penile deformity , cervical abnormalities, but also easy to cause miscarriage, stillbirth and ectopic pregnancy.

雌激素可引起胎儿先天性心脏缺陷，大血管畸形，脑积水，脑脊膜膨出，内脏畸形，脑积水，脑脊膜，膨出，内脏畸形，男胎女性化，阴茎畸形，宫颈畸形等，还易引起流产，死胎和异位妊娠。2、黄体酮可使妇胎生殖器男性化，出现阴蒂肥大，阴唇吻合等。3、先锋霉素：可通过胎盘屏障碍进入羊水中，对胎儿的安全性有影响。4、如有子宫收缩可引起先兆流产或先兆早产，应去医院请医生处方遵医嘱应用硫酸舒喘灵等舒缓平滑肌收缩的药物直至子宫收缩停止。

The trophoblast blood flow spectrum could be easily detected with the guide of CDE.The ultrasonic findings were characterized by broad arterial flow spectrum,high diastolic component of the low resistance trophoblastic flow,RI＝0.40～0.51 with single or biphasic spectrum.The salpingian ring with high blood flow indicated early and complete salpingian pregnancy.

结果：①异位妊娠包块血流信号丰富，血管连续性好，能较完整显示血管床、血管网及范围广的低流速血流信号；②脉冲多普勒取样为滋养层周围性血流频谱，其特征为：频谱增宽、单相或双相持续存在、阻力降低(RI＝0.44±0.04)、舒张期血流丰富的动脉频谱；③具有鲜明丰富的滋养层周围性彩色血流频谱特征的&输卵管环&是早期输卵管妊娠的特征性表现，并提示是输卵管完整存在的标志。

In another word, after the attachment phase, the high VEGF levelscould provoke an increase in the subperitoneal vascular network and facilitate implantation and viability in the retroperitoneal space.

异位症患者的在位内膜分泌期VEGF的表达，可能与内异症的组织发生有关；异位内膜VEGF表达，可能与内异症的发病有关；不同类型异位灶在血管化程度上无差别。

Between women with or without endometriosis, the expression of VEGFmRNA of eutopic endometrium in the secretoiy phase was significantly higher than that in the proliferative phase(P.05). eutopic endometrium of women with endometriosis both in the proliferative phase and secretoiy phase expressed higher level VEGFmRNA than that in control group(P.05). Conclusion:①The expression of VEGF is adjusted by female'hormone.②VEGF is a very important factor that may contribute to the pathegenesis of endometriosis by promoting neovascularization,explanting of ectopic endometrium , increasing activity of angiopoiesis in eutopic endometrium③VEGF is a efficient organism maker to reflect invading growth, prognosis and metastasis potency of EMs.④VEGF may paly an important role in both pathogenesis and progress of endometriosis.

EM 患者VEGF 水平受女性性激素周期性调节；VEGF 是导致EM 发生特别是在位内膜血管活性增强、异位内膜种植、新生血管形成的重要机制，提示血管生成是EMs 发生中的一个重要因素；VEGF 可能不仅参与EM 的形成，并与进一步发展存在关系，提示血管生成在异位子宫内膜的种植、浸润中可能起着重要的病理生理作用，是EM 发病的必要环节；VEGF 是反映EM 侵袭生长、转移潜能、预后的有效生物指标，提示通过使用抗血管生成药物或抗血管生长因子抗体，来阻断血管生成，极有可能成为EM 在现有药物和手术治疗基础上的一种有效治疗策略和靶点。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。