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血管反射

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The discovery of the Bainbridge reflex 70 years ago, of a tachycardic response to a rise in central venous pressure, stimulated a lot of interest in this and other cardiovascular reflexes.

Bainbridge reflex发现于70年前,指中心静脉压力的增高导致心动过速,当时引起了人们对此以及其他心脏血管反射的兴趣。

This review and our recent studies suggest that:(1) baroreceptor reflex is blunted in heart failure;(2) central angiotensin Ⅱ and reactive oxygen species play an important role in blunted baroreceptor reflex;(3) cardiac sympathetic afferent stimulation and chemoreceptor reflex inhibit baroreceptor reflex; and (4) exercise training normalizes abnormal reflexes in the heart failure state.

本综述及我们近年的研究表明:(1)在心力衰竭状态下压力感受性反射功能明显减弱;(2)中枢血管紧张素Ⅱ和活性氧在压力感受性反射功能失调中发挥关键作用;(3)心交感传入刺激和化学感受性反射能抑制压力感受性反射;(4)适当的运动可以部分纠正异常的心血管反射活动。

This review and our recent studies suggest that:(1) baroreceptor reflex is blunted in heart failure;(2) central angiotensin II and reactive oxygen species play an important role in blunted baroreceptor reflex;(3) cardiac sympathetic afferent stimulation and chemoreceptor reflex inhibit baroreceptor reflex; and (4) exercise training normalizes abnormal reflexes in the heart failure state.

本综述及我们近年的研究表明:(1)在心力衰状态下压力感受性反射功能明显减弱(2)中枢血管紧张素Ⅱ和活性氧在压力感受性反射功能失调中发挥关键作用;(3)心交感传入刺激和化学感受性反射能抑制压力感受性反射;(4)适当的运动可以部分纠正异常的心血管反射活动。

Observed the effect of renal sympathetic nerve activity in depressor reflex induced by phenvlcphrine by intravenous injection, after anesthetized rats were injected vasopressln antagonist OPC-2 1 268 in lateral ventricle, inquire into centre regulatory function of vasopressin in baroie flex.This experiments was performed on male Wistar rats weighting 280?

然而,在中枢对压力感受性反射的调制作用却有不同的提法在实验观察麻醉大鼠侧脑室注射血管升压素受体1阻断剂OPC-21268对静脉注射苯肾上腺素诱发的减压反射中所表现的肾交感神经放电活动的影响,探讨血管升压素在压力感受性反射的中枢调节作用。

General hypothermia was produced in 27 rabbits under nembutal anesthesia by immersing in an ice water bath, during the course of which, the carotid blood pressure was registered, the depressor and pressor reflexes elicited by faradic stimulation of the central end of the depressor nerve and by temporary occlusion of one side of the carotid artery respectively were examined.

三选择性头部低温与全身低温一样地引起血管内感受性反射的减弱,这说明全身低温时的上述反射变化主要取决於低温对神经中枢的作用,而这种作用可能使中枢处於间生性抑制状态。

METHODS: Healthy, pigmented, adult guinea pigs of both sexes with intact Preyer's reflex were divided into 3 groups (cochlea group,brain group and lung group).

成年健康杂色豚鼠,耳廓反射灵敏,分别取耳蜗、脑、肺三组组织,免疫组织化学法及Western Blot研究紧密连接蛋白occludin,ZO-1在耳蜗外侧壁血管纹中的表达,以脑组、肺组为阳性对照。

After treatment with the above hormones, the rats were established anesthesia with urethan (1g/kg, i. p.); polyethylene catheters were inserted into the external jugular vein and the common carotid artery for drug administration, and then blood pressure was recorded. The arterial catheter was connected to a pressure transducer, and the blood pressure was displayed on the channel of BL-310 Experimental System of Biological Function through IBM computer. We assessed the changes of resting arterial blood pressure, the pressor responses of angiotensin Ⅱ(Ang Ⅱ, 0.01mg/kg), noradrenaline (NA, 0.01mg/kg) and adrenaline (Adr, 0.016mg/kg). The depressor responses of Ach (0.006mg/kg) and carotid sinus baroreflex were also discussed after treatment with the hormones in OVX rats.

用不同雌激素处理21天后,将动物用25%的氨基甲酸乙酯腹腔麻醉(1g/kg),做颈总动脉插管,通过压力换能器,将血压变化输入计算机,通过BL-310智能型生物信号显示与处理系统的压力测定模块,观察去势鼠及不同雌激素替代治疗大鼠静脉注射血管紧张素Ⅱ(AngⅡ,0.01mg/kg)、去甲肾上腺素(NA,0.01mg/kg)、肾上腺素(Adr,0.016mg/kg)的升压反应以及乙酰胆碱(Ach,0.006mg/kg)的降压反应和压力感受性反射的变化。

As a result of high blood pressure can also lead to reflex vasoconstriction, which is why the treatment of angina pectoris should be used as well as blood pressure lowering drugs.

由于过高的血压也会引起反射性血管收缩,所以应使用既能治疗心绞痛,又能降血压的药物。

In 15 anesthetized open-chest dogs, the responses of some regional vascular beds were examined by constant flow perfusion method during the 5-HT-induced aortic hypertensive chemoreflex.

在15只麻醉开胸犬中,用在体器官恒流灌注法研究了骨胳肌、皮肤、肾和心脏的血管在5-HT诱发的主动脉区化学感受性升血压反射中的反应,同时还观察了5-HT对这些器官血管的直接效应。

The above-mentioned results illustrate: the mechanism of pseudobulbar palsy treated with nape needle was possible about brain plasticity after stroke, for example, it could relieve spasm of muscle, recovery muscle strength, facilitate pharyngeal muscle to move coordinated; formate long term protention with uninterrupt mechamism stimulations , reconstructe damaged reflex arch ; accelerate blood circulation, ameliorate ischemia and anoxia; influence metabolism of angeogenesis growth factors, improve angiogenesis and protect neurons.

项针治疗脑卒中后假性延髓麻痹的疗效肯定,其机理可能主要与缓解肌肉痉挛,恢复肌力,促进咽部肌肉的协调运动;对病变部位长期不断的机械刺激,形成长期强化作用,使受损反射弧得以重建;促进血液循环,改善病变局部缺血缺氧状态;影响血管生成生长因子的代谢,促进血管生成,保护神经元等,脑卒中后脑可塑性改变有关。

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