血管作用的

Acted as a kind of plant antitoxin, the resveratrol not only can improve the antipathogen ability of plant,but also have special health care function to the mankind,especially in the cardiovascular protection function,which caused extensive concern.

白藜芦醇作为一种植物抗毒素，不仅能提高植物抗病原体的能力，而且对人类有特殊的保健作用，尤其是其在心血管方面的保护作用引起了广泛的关注。

METHODS: The skinned first class arborization of superior mesenteric artery from HS rats were adopted to observe the influence of inhibitor of ZIPK on the effects of PKCα and PKCε agonists on calcium sensitivity after shock via measuring the contraction initiated by Ca2+ with isolated organ perfusion system, hypoxic vascualr smooth muscle cells were adopted to measure the protein expression and activity of ZIPK after applying PKCα and PKCε agonists following hypoxia via Western blotting.

采用离体微血管环张力测定技术，观察褪膜后抑制ZIPK对PKCα、PKCε激动剂增高失血性休克肠系膜上动脉一级分支微血管钙敏感性作用的影响；同时观察缺氧血管平滑肌细胞在PKCα、PKCε激动剂作用下ZIPK蛋白表达、活性的变化。

The former studies have shown Concentrated Xuefu Zhuyu Pill have effects on many pathological factors of restenosis, such as platelet agregation and adhesion, SMC proliferation,and it can prevent restenosis after PTA (percutanous transluminal angioplasty) of experimental illac artery AS of New Zealand rabbits.

因此，在动物实验证明血府逐瘀浓缩丸具有抗动脉粥样硬化，抑制AS家兔血管SMC增生作用，以及在防治家兔动脉粥样硬化PTA后再狭窄方面有一定作用的基础上，我们开展了其对冠心病人PTCA后再狭窄的防治研究。

Only unbound drug is thought to be available for passive diffusion to extravascular or tissue sites where pharmacologic effects occur.

一般认为，只有非结合药物才能通过被动扩散到达产生药理作用的血管外或组织部位，因此，非结合型药物浓度和药物效应以及和作用部位的药物浓度关系更密切。

To evaluate the vascular response in relation to baseline, adjusting for systemic effects and skewed data, we expressed the hyperemic response as the natural logarithm of the ratio of postdeflation to baseline pulse amplitude in the hyperemic finger divided by the same ratio in the contralateral finger that served as control.

为了评价血管反应性与基线血管反应的关系，校正全身性作用及偏离的数据，我们计算袖套排气后充血手指脉搏幅度与基线脉搏幅度的比率以及对侧作对照手指的脉搏幅度与基线脉搏幅度的比率，两比率之比取自然对数表示充血反应。

The sulfamate moiety in the structure of topiramate is chemically related to known CA inhibitors, and in fact, topiramate inhibits CA activity. To further explore the pharmacological action of topiramate, and clarify the possibility of anti-tumor growth and metastasis of CA inhibitors and its relation with AQP1, we studied the effect of topiramate on adhesion of high metastatic prostate carcinoma to laminin, and established the spontaneous metastatic model of Lewis lung carcinoma to studied the influences of topiramate on tumor growth and metastasis and AQP1 expression in lungs and primary tumors of mice.

为了深入研究托吡酯的药理作用，阐明CA抑制剂和水通道蛋白AQP1相互作用影响肿瘤生长和转移的可能性及其机制，我们研究了托吡酯对高转移的前列腺癌细胞粘附于基质成分层粘连蛋白的影响；以Lewis肺癌自发性转移为模型，考察了托吡酯对肿瘤生长和转移的影响；同时观察了托吡酯对荷瘤小鼠肺组织及原发瘤组织AQP1表达的影响；检测了其对血管新生的作用；利用体外AQP1表达模型，研究了CA抑制剂对AQP1功能的影响；此外，用蛋白质组学的关键技术，通过对模型组与托吡酯治疗组血清蛋白质组的比较分析，来寻找与肿瘤转移相关的蛋白质，探索托吡酯的可能作用靶点。

The "leifengshi-1" suppress the vascularization. And this function is possibly realized by reducing the expression of necrosis factor alpha and cyclooxygenase-2 in the synovia.

类风湿1号具有抑制CIA大鼠关节滑膜新生血管生成的作用，该作用可能通过下调滑膜组织TNF-α和COX-2的表达来实现。

CGRP has a protective effect on blood vessels in renal arterial hypertension,but ET1 exerts a vasoconstrictive action.

ET1与CGRP是心血管系统中的一对拮抗因子，与CGRP的作用相反，ET1有较强的缩血管作用，从而导致血压升高。

Though the primary stimulator of 1H is not clear, it is related to physical, cell and body fluid IH is a chronic process involving multiple faction injury and blood flowing abnormal are revamped as the main reason, the proliferation level depend on the length and width of the injure of vessel large amount research illustrate injury cause many growth factor infolded in IH, for example: template derived growth factor, fibroblast growth factor, transmission growth factor , endothelin (ET-1) et al, some early responsive gene such as c-fos、c-jun c-myc also take part in SMC proliferation after vessel injury.

虽然IH的确切起始刺激因子并未阐明，但已知与物理、细胞和体液因子有关。IH是一个多因素参与的慢性过程，损伤和血液动力学异常一真被认为是IH的主要因素。内膜增殖的程度有赖于血管损伤的长度和深度。近年来大量的实验研究结果表明，损伤等刺激引起的众多的生长因子样物质在IH中起关键作用。如血小板源性生长因子、碱性纤维母细胞生长因子、转化生长因子β、内皮素-1（ET-1）等诸如C-fos、C-jun、C-myc等早期应答基因也参与了血管损伤后SMC的增殖。

Which play a major role in the pathological changes of restenosis after angioplasty But AT2 receptor is only expressed abundantly in the fetal vasculature with rapid decline after birth and the level of re-expression in the adult vasculature after injury is very low So there are little understanding about the actions of AT2 receptor in vascular diseases, especially in the restenosis after injury.

在寻致或加重VSMC增殖和迁移诸多因素中，血管紧张素Ⅱ所介导的生物学作用是其中重要的因素之一。AngⅡ具有多种生物学作用，其作用的多样性是通过其受体的多样性介导的，目前已确定的AngⅡ受体至少有两型，即AngⅡ 1型受体(AT1R)和AngⅡ 2型受体(AT2R)。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。