血管作用的

The accentuation of vascular sensitivity to α2-AR agonist may be one of the mechanisms of abdominal aorta hyperreactivity.

对α2-AR之激动剂敏感性上调可能是高位SCT大鼠腹主动脉高反应性的原因，而α1-AR在血管高反应性中不起作用。

Aim To investigate the effects of gene expression through activating endothelial target for acetylcholine.

目的研究激活乙酰胆碱作用靶标血管内皮细胞基因表达的影响。

And it is involved in the energy metabolism, cell proliferation, hemogenesis and vessel formation and remodeling.

HIF-1α通过调节多种基因的表达来调节细胞对低氧的适应性反应，是迄今为止发现的唯一的一个在缺氧状态下发挥特异性活性的调节分子，被认为是调节缺氧相关基因表达的关键分子，它同激活蛋白(activated protein 1， AP-1)，核转录因子(nuclear factorκB， NF-κB)和p53等协同作用调节机体对缺氧的反应，其功能涉及能量代谢、细胞增殖、造血作用、血管形成、重塑与收缩等诸多方面。

Results:(1) CBC possesses a natural trabecular structure. Its components is similar to the mineral of bone.(2) CBC has great cellur biocompatibility. It can promote cell adhesion, proliferation and secretory while needn t modification.(3) In nude mice, the ectopic osteogenesis of MCCAB was obvious which was better than that of CBC alone and the new bone formation increased in pace with time. In the MCCAB, both intramembranous and cartilaginous osteogeneses were seen but the former dominated.(4) When MCCAB was autotransplanted intramuscularly, the osteogenesis was much better than that of negative control groups.(5) The MCCAB can repair autogenous calvaria defects effectively and the effect was much better than that of CBM alone and blank group. Conclusion:(1) CBC possesses good biocompatibility, osteoconduction and porous structure, can be used as scaffold material for constructing of tissue engineering bone.

结果：(1)CBC具有天然的多孔网状结构，最大程度地保持了骨矿的微结构特征，可以作为骨组织工程的支架材料；(2)CBC细胞亲和性好，不需作修饰即能促进成骨细胞的粘附、增殖和分泌活动；(3)MSO/CBC复合人工骨在裸鼠皮下异位成骨作用明显，兼有膜内成骨和软骨内成骨的特点，成骨效果明显优于单纯CBC植入组；(4)MSO/CBC复合人工骨兔自体肌袋异位成骨作用明显，血管化充分，成骨效果明显优于单纯CBC植入组；(5)MSO/CBC复合人工骨修复兔颅骨临界性缺损效果好，明显优于单纯植入CBC组和空白对第四旱区大学硕士学位论文一照组，可以作为骨移植替代材料用于骨缺损畸形修复。

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

Can eat "foods can lower blood pressure", such as celery, have a good blood pressure lowering effect, especially celery root煎服better; water chestnuts, jellyfish head: The 1-22, wash away the salt, making soup drink name "Snow soup," have a good blood pressure lowering effect; spinach containing protein, cellulose, sucrose, glucose, fructose and vitamin B, C, D, K, P, can be used as the treatment of hypertension and diabetes medicinal food; taking royal jelly for three abnormal lipid disorders, arteriosclerosis, arrhythmia, diabetes and other diseases also have a good effect.

冬季也可以吃些&能降血压的食物&，如芹菜，有良好的降血压作用，尤以芹菜根煎服为佳；荸荠、海蜇头：各一至二两，洗去盐分，煮汤饮，名&雪羹汤&，有良好的降血压作用；菠菜含有蛋白质、纤维素、蔗糖、葡萄糖、果糖和维生素B、C、D、K、P，可作为治疗高血压和糖尿病的药用食物；服用蜂王浆对三脂异常症、血管硬化、心律不齐、糖尿病等疾病也有很好的疗效。

In the previous studies the constituents from Cinnamomum philippinense reported to have the biological activities such as antiplatelet aggregation, vasorelaxation, cardiac muscle contraction, antioxidation and free radical scavenger activities etc. Furthermore, MA-1 a ligan isolated from Cinnamomum philippinense is considered to be an important prophylaxis to treat ischemic stroke due to its antioxidation and free-radical scavenger activities. The present project aims to develop MA-1 as a pre-medicine to treat ischemic stroke.

在过去的研究中，发现菲律宾樟树所含的成分对心脑血管相关的活性诸如抑制血小板凝集、血管松弛、影响心肌收缩、抗氧化、自由基清除等具有不错的活性作用，而由菲律宾樟树所分离得到的一种新木质酚MA-1，具有抗氧化作用且是自由基捕捉剂，获选为开发成缺血性中风之预防与治疗先导药物。

BACKGROUND: The selection of scaffold materials is influenced by many factors, such as the implant vectors, the slow-release effect of the cytokines, the promotion effect on the growth of blood vessel, cartilage and bone after implantation, the suitable porosity, and three-dimensional structure as well.

背景：植入材料的载体作用、细胞因子的缓释作用以及植入后利于血管、软骨、骨的长入，适当的孔隙度及材料内部的三维结构都是影响支架材料选择的因素。

Vitamin C in the human body's role is to improve the sensitivity of the extent of cranial nerve and the brain to stimulate the response of a flexible, but also improve the immunity and resistance to disease, can improve the body's ability to adapt to cold and blood vessels has a good protective effect.

维生素C在人体内的作用是提高脑神经的灵敏程度，使脑对刺激的反应灵活，还能提高免疫力和抗病能力，能提高人体对寒冷的适应能力并对血管具有良好的保护作用。

The animal model of this method system have, the characteristics of the high fat, high leptin, high Ins, and match with the characteristic of clinical and the pathologic of simple obesity. This studies showed: The acupuncture can obviously reduce the vaule of intaking food and water of the fat rats, and lower the body weight and fat; The acupuncture can urge the diameter, area, physical volume of white fat cell contract, Brown fat tissue of fat rat group surroundings vascular containing large quantity of white fat cell, the acupuncture group was less. this showed: The acupuncture enhanced the white fat cell metabolism, and promotesed the white fat cell to convert to brown fat cell; The frequency of spontaneous electric of nerve cell of pvn of the fat rat is high, the acupuncture counld depress the spontaneous electric of nerve cell of pvn, This showed: the acupuncture can depress the appetite passing to adjust function of pvn nerve; The monoaminergic neurotransmitter of inside of the fat rat brain is disfunction, the acupuncture can rectify this disfunction, and adjust level of 5-HT, and affect appetite, and improve metabolism; The level of leptin and Ins of fat rat increased high, The level of it of acupuncture group decreased, compared with the fat group p.001, This showed: the fat rats have the defeat of leptin and Ins in the body, The acupuncture can lowering this defeat, The level of leptin and Ins of the fat rat in the brain is less than the normal group, The level of leptin of the acupuncture group is high than the fat group, This showed: the acupuncture can increase the transportation of leptin from blood to brain.

本方法所制肥胖大鼠模型具有高体重、高脂、高leptin和高Ins血症的特点，符合人类单纯性肥胖病的临床和病理特征；实验研究显示：针灸能明显减少肥胖大鼠的摄水、摄食量及降低其体重、体脂；针灸能促使白色脂肪细胞直径、面积、体积缩小，减少肥胖大鼠棕色脂肪组织血管周围白色脂肪细胞数量，显示：针灸增强了白色脂肪细胞的代谢，促进了白色脂肪细胞向棕色脂肪细胞的转化：肥胖大鼠PVN神经细胞自发放电频率增加，脑内单胺递质紊乱，针灸通过抑制PVN亢奋的自发放电，调整5-HT水平，达到影响食欲，改善代谢的作用；肥胖大鼠血中leptin及Ins水平增高，与正常组大鼠比有明显差异，提示大鼠体内存在leptin及Ins抵抗，针灸后肥胖大鼠随着体重体脂的下降，血中leptin、Ins水平降低，与肥胖组比均有显著性差异，而针灸后大鼠脑内leptin增加，与肥胖组比P.05，提示：针灸具有改善leptin、Ins抵抗及增加leptin脑内转运的作用。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐