血管作用的

Genesis,development and metabasis of solid tumor have close relationship with tumor vessel angiogenesis; extracellular matrix degradation is the key point for tumorous infiltration and metabasis;the significant biology characteristic of tumor cell is the disorder of tumor cell differentiation and apoptosis.

骨巨细胞瘤血管生成是近年来研究热点，实体瘤的发生、发展及转移与肿瘤的血管生成密切相关；细胞外基质降解在肿瘤的浸润和转移中起到关键作用；肿瘤细胞的分化凋亡障碍与无限增殖能力是肿瘤细胞的重要生物学特征。

Giant cell tumor of bone is a kind of common bone tumor,which has characteristics of high recurrence rate and invasion.recently,tumor vessel angiogenesis has been the warm spot of research.genesis,development and metabasis of solid tumor have close relationship with tumor vessel angiogenesis; extracellular matrix degradation is the key point for tumorous infiltration and metabasis;the significant biology characteristic of tumor cell is the disorder of tumor cell differentiation and apoptosis.the correlated research has very important significance for judging gct prognosis and guiding therapy.

骨巨细胞瘤（giant cell tumor of bone，gct）是一种常见骨肿瘤，由于其高复发率和强侵袭性，备受临床骨科工作者的关注。骨巨细胞瘤血管生成是近年来研究热点，实体瘤的发生、发展及转移与肿瘤的血管生成密切相关；细胞外基质降解在肿瘤的浸润和转移中起到关键作用；肿瘤细胞的分化凋亡障碍与无限增殖能力是肿瘤细胞的重要生物学特征。骨巨细胞瘤生物大分子研究的不断深化对判断gct的预后及指导治疗有重要意义。

Among them,therole of Vasomotor dysfunction and imbalanceof vascular tension factors are important in the happening and development of ASO,and that has become a focal point of investigation ."WenMaiTong"is an effective formula to treat early ASO, and the total effective rate is 98.1% in clinic.

国内外学者对ASO的发病机理已做了深入的研究，其中血管舒缩功能障碍及血管张力因素分泌的不平衡在ASO的发生发展中起着重要的作用，正日益成为人们研究的焦点之一。

MCP-1 is up-regulated significantly in collateral vessels, which suggests its importance in mediating macrophage invasion during arteriogenesis.

在生长的侧枝血管MCP-1的表达显著上调，提示MCP-1在巨噬细胞的聚集和侧枝血管的生长过程中具有十分重要的作用。

Methods: 1 To establish rat AS models, rats in the experiment were divided intofive groups: normal control group, hyperlipidemia group (fed with high-cholesterol diet), hyperlipidemia + vitaminDS group, hyperlipidemia + vitamin D3 + endothelium denudate group,losartan group (hyperlipidemia +vitamin D3 + endothelium denudate group treated with losartan).

本实验从AS的主要的三种发病机制出发，建立和比较了三种建立大鼠AS模型的方法；同时以该模型为基础，探讨了MMP-9/TIMP-1的动态平衡与AS的关系；也研究了血管组织及血浆血管紧张素H水平与AS的关系；探讨了AngⅡ 1型受体拮抗剂氯沙坦是否具有抗AS作用，以及机制如何。

Elastic fibers were well-distributed,and vascular endothelial cell did not immigrate.We suggested that expression of ectogenic VEGF triggered paracrine and autocrine of VEGF of chondrocyte and co-acted with VEGF receptor 2 to enhance permeability of chondrocyte and improve internal construct of engineering cartilage,and prevent vascularize proceed.

转VEGF基因软骨细胞作为组织工程的种子细胞与pluronic F-127复合后可于裸鼠体内形成转基因组织工程软骨，与对照组相比，转VEGF基因组织工程软骨具良好的生物学特性，结构均一且与正常软骨组织相似，软骨ECM的GAG、COLⅡ、COLⅩ增多，RunX2、Sox9表达增高，细胞处于增生期的肥大状态，初步分析其原因可能是转染后外源性的VEGF持续表达触发了软骨细胞VEGF自分泌，并通过VEGFR-2作用于软骨细胞，提高了软骨细胞活性，促进其存活与增殖，但未在软骨组织内引起血管内皮细胞的迁移及小血管形成。

With the development of lesion inautonomic nervous system, i.e. the elevation of baroreflex set point, blood pressureincreases to stage 1 hypertension and worsens. Furthermore, the role of the effectors,including PVR, ventricular end-systolic elastance, venous unstressed volumes and heartrate, in the regulation of hypertension was analyzed. The results exhibit that the ANSregulation on hypertension works mainly by the reduction of PVR and the increase ofvenous unstressed volume.

随着自主神经系统损坏程度的不断加重，即工作调定点进一步升高，血压水平上升到了1级高血压并趋于严重；研究了神经调节的各效应器(外周血管阻力、心肌最大弹性度、心率和静脉非压力容积)对高血压的作用，表明神经调节机制对高血压的调节主要是通过降低外周血管阻力和增加静脉非压力容积实现的。

Objevtive: To investigate the effect of effective parts of Zingiber officinal on the adhesion of ECV-304 cells with monocytes cultivated in vitro and on the expression of monocyte chemotactic protein-1 (MCP-1) and adhesion molecules.

中文摘要：目的：研究鲜姜有效部位对离体培养的血管内皮细胞与单核细胞的黏附力及对单核细胞趋化蛋白和黏附分子表达的影响，探讨其保护血管内皮细胞的作用机制。

The mechanism may be related with the action of increasing β-EP content in hypothalamus and blood plasma and dilating peripheral blood vessel.

脉痛宁有明显的镇痛作用，其镇痛机制可能是通过提高大鼠中枢和周围血浆中β-EP含量和通过扩张周围血管发挥镇痛作用。

Tongxinluo also significantly increased the CO content. Conclusion: Herbs to dredge collaterals can induce CO production by ameliorating or recovering the HO System, which may be one of the mechanisms for protecting the vascular tissues.

通络方药可通过增加内源性CO发挥细胞保护作用，该作用可能与其改善或修复HO系统、提高HO-1表达有关，这可能是通络方药保护血管组织免遭损伤的机制之一。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐