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Part Two: The effect of fruit extract on CRL-2606 production of PGE2 Effect of anthocyanin rich fruit extracts on endothelial cells'PGE2 production Epidemical experiment shows that phenolics in fruits and vegetables may prevent the occurrence of chronicle cardiovascular heart disease. To investigate the activity of fruit extracts on artery blood vessel cells, we chose CRL-2606 cell line, a normal iliac artery endothelia cells. Using indomethacin as control, we investigate the effect of blueberry extracts, blackcurrant extracts, chokeberry extracts, cyanidin3-glucoside, and malvidin3-glucoside on the PGE2 production of CRL-2606 cells.

第二部分水果提取物对人体细胞系CRL-2606产生PGE2的影响水果提取物对血管内皮细胞释放PGE2的影响流行病学调查表明,蔬菜水果中的多酚类物质具有预防慢性心血管疾病的作用,为研究水果提取物对血管细胞的作用,我们选择回肠动脉内皮细胞CRL-2606细胞系作为研究对象,以indomethacin为对照,研究了blueberry,blackcurrant,chokeberry提取物及cyanidin3-glucoside,和malvidin3-glucoside对血管内皮细胞释放PGE2的影响。

OBJECTIVE: To explore the vascularization effects of release of vascular endothelial growth factor from VECM in ureteral reconstitution.

目的:探讨血管细胞外基质在修复输尿管缺损中释放血管内皮生长因子增强血管化的作用。

Constituting a tube; having hollow tubes同义词:tubular, cannular, tubelike, tube-shaped vasoactive

a。 血管活性的,(尤指在血管的舒张或收缩方面)作用于血管的,影响血管的 vasoconstriction

Results: The total saponins of Achyranthes Bidentata Blume not only had significantly inhibitive effects on NE-induced vasoconstriction, but also had direct relaxation effect on vascular smooth muscle.

结果:怀牛膝总皂苷不仅对NE引起的血管收缩有显著的抑制作用,而且还有直接舒张血管平滑肌的作用。

Objective To observe the effects of angiosteosis on the tension of thoracic aortic ring in rats in vitro and its mechanism.

目的:在大鼠血管钙化模型上,观察血管钙化对血管张力的直接影响,并探讨其作用机制。

FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th/Ts and Th1/Th2 cells balance in peripheral blood, restrain exorbitant TNF-α、IL-1 produced by PMφ, thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF-αmRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflammation and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue, reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage. Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果:(1)FSN有明显的抗炎作用,可显著抑制AA大鼠足跖肿胀与多关节炎,改善大鼠的全身情况,同时明显减轻病变关节滑膜炎症与增生,防止关节软骨及骨质的破坏,其综合作用优于TWP;(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常,纠正外周血中T细胞亚群Th/Ts及Th1/Th2平衡紊乱,抑制大鼠PMφ过高的TNF-α、IL-1分泌,而发挥抗炎和免疫调节作用;(3)在病变关节局部,FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达,降低滑膜组织中NF-kB表达,并增加凋亡蛋白酶Caspase-3表达,从而抑制滑膜的炎症与增殖;(4)FSN还可下调滑膜组织中VEGF表达,减少血管新生,由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀;(5)FSN的上述作用皆呈现一定的量效依赖关系,高剂量组作用优于低剂量组。

Recombinant hANG had no effect on the expression of VEGF and bFGF in both SMCC-7221 cells and HUVEC cells, suggested that hANG exerted its antiangiogenic role not through the inhibition of the autosecretion and parasecretion of angiogenic stimulatory factors VEGF and bFGF.

重组人血管抑素对SMMC-7721肝癌细胞及HUVEC细胞中两种血管生长刺激因子VEGF和bFGF的表达没有影响,提示血管抑素对肿瘤血管生长的抑制作用不是通过抑制血管生长刺激因子的自分泌和旁分泌来实现的。

The SPECT imaging of ~(99)Tc~m-GEBP11 can show the tumor mass clearly and ~(131)I-GEBP11 has anti-tumor effect with weak toxicant and secondary effect, which is the foundation for them to develop nuclide probe or radiotherapeutics drugs targeting to tumor vasculature.3. GEBP11 can inhibit angiogenesis, which comes true probably through its inhibition effects on the proliferation, invasion, migration and adherence of ECs.

1、GEBP11具有活体内胃癌血管靶向结合的能力,它与胃癌血管内皮细胞膜受体特异结合后可被内化。2、~(99)Tc~m-GEBP11 SPECT成像能较好地显示体内肿瘤灶,~(131)I-GEBP11具有明显的抗肿瘤效应及较弱的毒副作用,为开发肿瘤血管成像核素探针及受体放射治疗新药奠定了基础。3、GEBP11具有抑制胃癌血管生成的作用,这可能通过抑制ECs增殖、基质降解及迁移、粘附能力实现。

These results indicate that apelin-13 relaxes the thoracic aorta in the two groups and the response of vasodilatation is enhanced in the rat thoracic aortas from the 2K1C hypertension group. It may be an important protecting factor and play an important role in the protection of blood vessel.

Apelin-13具有显著的舒张主动脉的作用,并且对高血压大鼠血管环的舒张作用更强,提示Apelin-13在血管的保护作用中扮演了重要角色。

Bloodginseng in Yunnan pollen bloodginseng oral liqui" lives blood to turn off sludge and remove the gruel kind of accretion off the vessel wall to keep it smooth, help the blood to cycle comletely and urge and bring bodyinside "nucleic acid"or nucleotide and other apoenzymes in the food to all parts of body thus absorbed by each organ of human body to repair the damaged genes or section of the gene chain namely cell that need to be metabolized,they have thus the function of "repair the gene chain"; Thus taking orally the "pollen bloodginseng has assistant treatment functions described on its packing box or so-called the health care functions.

&田七&具有活血化淤、消除血管壁上的粥样淤积、保持血管平滑、促进血液循的功能,从而促使 RNA 及 DNA 与食物中的其它酶蛋白一道在人休各部位合成基因蛋白被人体各器官所吸收修补其受损即需代谢的细胞,从而起到&修补基因链&的作用;起到&云南花粉田七&口服液包装盒上面所标出的辅助治疗作用或称保健作用。

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