血管作用的

Objective To determine the content change of vascular endothelial growth factor and basic fibroblast growth factor in the wound fluid and their effect on angiogenesis in the wound healing during healing of maxillofacial soft tissue blast injury. Methods The improved rabbit model of maxillofacial blast injury was made by KTY-04 blasting cap.

摘 要：目的探讨颌面部软组织爆炸伤愈合过程中血管内皮细胞生长因子和碱性成纤维细胞生长因子在伤口液中含量的动态变化及其对创伤愈合中血管再生过程的刺激作用。

They also did ultrasound and other tests to measure blood vessel function and the thickness of the artery wall.

他们还进行了超声波和其他测试，衡量血管的作用和动脉血管的厚度。

In clinical. acetylcholinesterase inhibitors reduce the breakdown of synaptic acetylcholine, have been modestly effective in improving the cognitive deficits of Alzheimer's disease.The goal of this work is to determine enzyme kinetics and mechanisms of acetylcholinesterase and butyrlcholinesterase inhibition by five cardiovascular drugs, lovastatin, simvastatin, amlodipine besylate, nifedipine, and hydralazine hydrochloride, and two benzodiazepines, diazepam and chlordiazepoxide hydrochloride. All drugs in this study are reversible mixed-type inhibitors of acetylcholinesterase and butyrylcholinesterase. The pKi values for acetylcholinesterase and butyrylcholinesterase inhibition by the cardiovascular drugs are linearly correlated with the molecular weights of the drugs with the slopes of 0.005 and 0.0021, respectively. Therefore, van der Waals' interactions between acetylcholinesterase and the cardiovascular drugs are stronger than those between butyrylcholinesterase and the drugs. This is probably due to a smaller active site gorge and a more significant peripheral anionic substrate binding site of acetylcholinesterase than those of butyrylcholinesterase.

本研究之目的系决定乙醯胆碱酯酵素和丁醯胆碱酯酵素被五种心脏血管药物lovastatin， simvastatin， amlodipine besylate， nifedipine、hydralazine hydrochloride和两种benzodiazepines：diazepam和Chlordiazepoxide hydrochloride的抑制作用之动力学及机转，这些药物都是乙醯胆碱酯酵素和丁醯胆碱酯酵素的可逆性、混合型之抑制剂，实验结果显示，五种心血管药物对於乙醯胆碱酯酵素及丁醯胆碱酯酵素抑制之pKi值和药物之分子量呈直线之关系，斜率分别为0.005及0.0021因此丁醯胆碱酯酵素，与心血管药物间之凡德瓦作用（van der Waals' ）比乙醯胆碱酯酵素与心血管药物间者弱，这可能原因是丁醯胆碱酯酵素之活性区域比乙醯胆碱酯酵素之活性区域更宽广，但丁醯胆碱酯酵素之周边阴离子区域不及乙醯胆碱酯酵素之周边阴离子区域者明显重要，由於五种心血管药物对於乙醯胆碱酯酵素和丁醯胆碱酯酵素抑制之pKi值存在著线性关系表示此种抑制作用系经过共同之反应机理。

Studies also indicated that genistein exsists not only in soybeans but also in many kinds of plants such as vegetables and fruits.As a potential anticancer agent, the actional mechanisms of genistein mainly includes as follows:First, genistein can depress the activity of protein tyrosine kinase and transduction pathways for the phosphorylation of receptors and mitosis signal. So genistein can lead to cells' proliferation depressed. Second, genistein has minimal effects of phytoestrogens. It can be combined with estrogen receptor and improve the synthesis of cellular sex hormone binding glulobin, and improve the activity of UDP-glucuronyl transferase. Through these pathways, it can inhibit the cell activity of breast cancer and prostate cancer.

作为一个很有潜力的抗肿瘤物质，三羟异黄酮的作用机制主要包括：①抑制蛋白酪氨酸激酶活性，可阻抑PTK引起的受体磷酸化和有丝分裂的信号传递，导致癌细胞增殖受抑；②弱雌激素作用：可通过与体内雌激素受体结合，并可增加细胞内性激素结合球蛋白的合成，增加UDP-葡糖醛酸转移酶的活性等途径抑制乳腺癌和前列腺癌细胞活性；③拓扑酶Ⅰ和Ⅱ抑制剂，抑制细胞活性；④上调细胞周期性负性调节因子P21WAF1/CIP1的表达，使之负性调节因子作用增强；⑤可阻止胰岛素样生长因子-Ⅰ、肝细胞生长因子和神经生长因子的作用而抑制肿瘤生长；⑥其他：抗氧化作用、抑制热休克蛋白、诱导细胞凋亡、抑制新生血管生成和抑制多种耐药相关蛋白等。

After acetylating, the effect of the transformed PAF on platelet aggregation was compared with that induced by standard PAF for quantification.

目前发现PAF除引起血小板聚集外，还具有较为广泛的生物学作用，如增加血管通透性、促进白细胞趋化与激活、扩张血管、抑制心功能及收缩支气管等〔。

It has been postulated that Angiotensin Ⅱ type 2 receptor (AT2) functionally antagonizes ac 1 (AT1) receptor.

基于目前对血管紧张素Ⅱ2型受体（AT2）功能的认识，认为血管紧张素Ⅱ1型受体（AT1）和AT2受体有相互拮抗作用。

Vascular endothelial growth factor is the most critical growth factor for angiogenesis, and matrix metalloproteinase-9 (MMP-9) is associated with extracellular matrix degrading and bone resorbing.

血管内皮生长因子(Vascular endothelial growth factor，VEGF)在血管的新生中起重要调节作用，基质金属蛋白酶-9(matrix metalloproteinase-9，MMP-9)可降解细胞外基质，引起骨吸收。

Objective To investigate the levels of nitric oxide and nitric oxide synthase in asphyxia neonatorum and its significance on prognosis judgments.

一氧化氮及一氧化氮合成酶作为血管舒缩调节剂，在脑缺血或脑缺血再灌注损伤中具有不同的作用，包括保护作用及毒性作用[1] 。

VEGF is a specific mitogen of endothelial cells and also the only factor which can increase vascular permeability.

在这一过程中，血管内皮生长因子(Vascular Endothelial Growth Factor，VEGF)作为最重要的血管生成因子之一，起到了重要作用。

Although it is accumulated in the vitreous body during some pathologic states,seldom research has focused on its expression at retina of adult animal.

最近的研究表明，SDF-1在诱导出生后血管生成中起关键作用[1-4]，在糖尿病视网膜病变(diabetic retinopathy，DR)或其他眼内新生血管疾病中，其玻璃体内浓度升高[5-6]，但尚不清楚其组织细胞来源。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。