血管作用的

Vascular basement membrane, an important structural component of blood vessels, plays an important role in angiogenesis.

血管基膜是血管的重要组成部分，它在血管生成过程中起着重要的作用。

Meanwhile,concentrations of KP and ANP in atrium and aorta of the rats were observed as well.

KP不仅具有和ANP一样的利尿、舒张血管、抑制肾素-血管紧张素系统的作用，还具有抑制心肌Na+-K+-ATP酶的作用〔2〕。

Methods:By using transmission electron microscope and immunohistochemical technique,oncosis and TSP 1 expression in 57 cases of gastric adenocarcinoma were determined,and the interrelationship between them was studied.

血管形成在实体肿瘤的生长、浸润、转移中起着重要作用，凝血酶敏感蛋白1(thrombospondin1，TSP1)是一种有效的血管形成抑制因子，目前尚未见关于TSP1在胃腺癌中的作用报道。

rutaecarpine pharmacological effects and its related mechanism: rutaecarpine the heart positive inotropic, positive changes in the role and the heart protective effect, which with its promotion of calcitonin gene-related peptide release; rutaecarpine alkali have vasodilative and hypotensive effect, its mechanism mainly related to endothelial cells Ca2 +-NO-cGMP pathways and calcitonin gene-related peptide release; rutaecarpine to relax the anal sphincter, gastrointestinal motility inhibition of stress ulcer and ulcerative colitis have therapeutic effect; rutaecarpine on cerebral ischemia-reperfusion injury has a protective effect, which instead of increasing the concentration of calcitonin gene-related peptide-related; rutaecarpine inhibits platelet aggregation and arterial thrombosis; In addition, rutaecarpine Alkali also anti-inflammatory and analgesic, anti-tumor and other pharmacological effects.

综述了吴茱萸次碱的药理作用及其相关机制：吴茱萸次碱对心脏有正性肌力、正性变时作用和心脏保护作用，这与其促进降钙素基因相关肽释放有关；吴茱萸次碱有扩血管和降压作用，其机制主要涉及内皮细胞Ca2+-NO-cGMP途径和降钙素基因相关肽的释放；吴茱萸次碱能松弛肛门内括约肌，抑制胃肠运动，对应激性溃疡和溃疡性结肠炎也有治疗作用；吴茱萸次碱对脑缺血再灌注损伤有保护作用，这与其增加降钙素基因相关肽浓度有关；吴茱萸次碱能抑制血小板聚集和动脉血栓形成；此外，吴茱萸次碱还有抗炎镇痛、抗肿瘤等药理作用。

Taken together, these results indicate that Hypb is required for embryonic vascular remodeling and provide a tool to study the function of H3K36 methylation in vasculogenesis/angiogenesis.

我们的这项研究结果证明HYPB基因在血管发育中具有重要作用，并为下一步研究H3K36三甲基化修饰在血管发育中的作用机制提供了一个良好的模型。

AngiotensionⅡand endothelin-1 are two important vasoactive peptide,having powerful vasoconstricting and hemodynamic function,except this,both have nonhemodynamic effects as growth factor to induce proliferation,hypertrophy,to stimulate synthesis of matrix proteins,furthermore,also to inhibit matrix degradation, even to mediate inflammation reaction.

血管紧张素Ⅱ(angiotensinⅡ，AngⅡ)和内皮素1(endothelin1，ET-1)是两个重要的血管活性激素，除了血流动力学作用外，还有非血流动力学作用，如促进细胞增生、肥大，刺激细胞外基质的合成并抑制其降解，介导炎症反应。

Compared with SHRc , after 4 weeks, Pro-EGF mRNA expression level of SHRsv and SHRlv VSMC were significant lower.Conclusions: Valsartan decrease SBP of SHR, inhibit SHR VSMC proliferation, reverse vascular hypertrophy of thoracic aorta and mesenteric artery in SHR, improve the two arteries vasomotion function. Pro-EGF mRNA expression only in SHR VSMC, not in the VSMC of WKY. It indicated pro-EGF gene may play an important role in hypertension advance .

缬沙坦有效降压的同时，抑制SHR大鼠VSMC增殖，逆转其弹性血管和阻力血管的肥厚，明显改善其弹性血管和阻力血管的舒缩功能。pro-EGF mRNA只在SHR大鼠VSMC表达，而在WKY大鼠VSMC没有表达，提示pro-EGF基因可能在高血压的发生发展中起一定的作用，可能是高血压的一个病理机制。

VEGF can facilitate endothelial proliferation strongly and vasotropic growth with conjugating vascular endothelial cells specific receptor.

在众多的血管生成因子中，VEGF是最有力的血管生成因子，它通过和血管内皮细胞的特异性受体结合，具有强大的促内皮增殖、促血管生成作用。

At 14 days after operation, VCAM-1 was still positive on the surface of uncovered endothelium, while more abundant expression was seen in the bottom of neointima near internal elastic lamina. Conclusions NF-κB activation and VCAM-1 expression participate in the inflammation of rat denudated artery.

核因子κB和血管细胞黏附分子1参与大鼠的主动脉损伤后的炎症过程；核因子κB的活化与失活成动态变化；血管细胞黏附分子1不同时间表达在不同的部位，核因子κB的活化与失活在血管细胞黏附分子1的表达与消退之前，核因子κB对血管细胞黏附分子1的表达起调节作用。

ONOO〓 had direct vasoactive effect for relaxation of precontracted isolated pulmonary artery. Relaxing action of ONOO〓 was weak and was negtively regulated by endothelial cells, further supporting the notion that ONOO〓 may be involved in pulmonary hypertension in the early stage of ES.

用离体血管环检测张力方法，发现ONOO〓具有一定的舒张肺动脉作用，但舒张效应较弱，并受到血管内皮细胞的抑制性调节；抑制K〓通道和PARS活性可增强ONOO〓对离体兔肺动脉的舒张作用。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。