血管作用的

The first part consists of three experiments:(1) The rings were incubated in KH, 20, 50 mmol/L 〓 for 1 house, relaxation in response to the EDHF stimuli A23187 in 30nmol/L U46619-induced preconrtaction in the presence of 7 μ mol/L indomethacin, a cyclooxygenase inhibitor, 300μmol/L LNNA, a nitric oxide biosyhnthesis inhibitor, and 1mmol/L tetraethylammonium , a 〓 blocker, or 3 μmol/L glibenclamide , a 〓 blocker, was compared with the control;(2) After the arteries were incubated in KH, UW solution or HTK solution at 4℃ for 4 hours, endothelium-derived relaxation (percentage of 30nmol/L U46619 precontraction) was induced by A23187 in the present of 7 μmol/L indomethacir and 300μmol/L LNNA;(3) After incubation with KH, UW solution and STH (either at 37℃ in oxygenated organ chamber or at 4℃ in a refrigerator for 4 hours), endothelium-derived relaxation (percentage of 30nmol/L U46619 precontraction) was induced by A23187 in the present of 7 μ mol/L indomethacin and 300 μmol/L LNNA.

第一部分研究结果：（1）单纯浸泡于KH的冠状动脉A23187能引发66.67％的血管舒张反应，经TEA及20mmol／L、50mmol／L钾离子作用后，血管舒张反应程度显著降低，但经GBM作用后改变不明显；（2）与保存于KH的冠状动脉相比，A23187引发的血管舒张反应程度，保存于UW液的明显下降，保存于HTK液的无明显变化；（3）在37℃条件下，血管环浸泡于STH出现缓慢轻微的舒张反应，浸泡于UW液初期出现短暂收缩反应，但此后主要以舒张为主：在37℃条件下，血管经UW液保存后，U46619引发的收缩反应程度降低；不论在37℃或4℃条件下，A23187引发的血管舒张反应，经UW液保存后明显下降，但用STH保存后变化不明显。

From the perfusion experiments with isolated rabbit heart and vessels were obtained the follow- ing results:(1)Potassium antimony tartrate produced depression of the isolated rabbit heart,and this depressant action became more marked when the pH of the solution was raised from the original value of 5.4 to that of 7.2;(2)At the same pH levels,the cardiac action of the potassium salt was slightly stronger than that of the corresponding sodium salt;(3)The slight vase-dilator effect of potass- ium anti...

从离体器官的灌注实验得到下列结果：(1)酒石酸锑钾对离体兎心有抑制作用，将其pH 从5.4调整到7.2时，作用亦随以增加。(2)在相同 pH 时，酒石酸锑钾的心臓抑制作用较酒石酸锑钠略强。(3)酒石酸锑钾对离体兎耳血管的轻微扩张作用，系由于该药溶液的微酸性反应，当将药液 pH 调整至7后即无作用。(4)对于离体兎肺血管则不问 pH 为4.8或7，均产生轻微的血管收缩作用。

Wenxin capsule can promote endolethial cells releasing CO and synthesing 〓, enhance activity of HO, induce angiectasis through activating guanylic cyclase and adenglate cyclate of intracellar of vessel smooth muscle cell to enhance content of intracellar cGMP and AMP. 3. Wenxin capsule can inhibit releasing of platelet activiting factor 〓 which inhibit platelet aggregation and have antithrombosis function. 4. Wenxin capsule can promote activity of t-PA, reduce activity of PAI-1, strengthen fibrinolytic function, therefore inhibit fibrin disposition. 5. Wenxin capsule can inhibit synthesis of smooth muscle cellular DNA. Its function don't kill it directly but prevent transformation from period Go to peried S. 6. Wenxin capsule is an effective prescription of anti-coronary atherosclerosis atherosis. The results of image pattern analysis tastifies that area of lipid plaque in treating group reduce 54% and 58% in contrast with that in control group. The results of light, electro- microscopy show that structure of endolethial cell and smooth muscle cell in treating group is more integral than that in control group.

其作用机制之一是由于该药具有良好的调脂降脂作用，其不仅能明显降低血清LDL-c及升高HDL-c含量，且能有效阻止TC沉积于血管壁，从而保护内皮细胞结构完整；此外，温心胶囊尚具有明显的抗氧化作用，该药不仅能明显降低血浆LPO含量，且能提高SOD活性，同时其对血红素在细胞内代谢的调节作用也参与了抗氧化过程。2 温心胶囊能明显促进内皮细胞释放CO及合成〓，提高HO活性，通过激活血管平滑肌细胞内鸟苷酸环化酶及腺苷酸环化酶引起细胞内cGMP、AMP浓度增加而引起血管舒张。3 温心胶囊能明显抑制血小板激活因子〓的释放，从而抑制血小板聚集，抗血栓形成。4 温心胶囊能明显提高t-PA活性，降低PAI-1活性，增强纤溶功能，从而抑制纤维蛋白沉积。5 温心胶囊能明显抑制平滑肌细胞DNA合成，其抑制作用不是直接杀伤抑制，而是阻止细胞由Go期向S期转化。6 温心胶囊是抗冠状动脉粥样硬化的有效制剂，图象分析结果证实，该药治疗组脂斑面积比对照组缩小了54％和58％，光电镜结果显示内皮细胞及平滑肌细胞结构较为完整。

The expression of Bcl-2mRNA and P53mRNA in hippocampus after 16Hz, 130dB infrasound treatment In 1 day group, Bcl-2mRNA and P53mRNA were expressed lightly in CA1-CA3 areas in hippocampus and dentate gyrus. Blood vessels dilated lightly. In 7d group, Bcl-2mRNA and P53mRNA were more expressed in areas mentioned above. Dilation of capillaries and small vessels was more obvious. Bcl-2mRNA and P53mRNA were strong positive in endothelial cells of vessels. In 14d group, Bcl-2mRNA and P53mRNA expression was obviously increased in pyramidal cells of hippocampus and granular cells of dentate gyrus, showing deep blue staining. a The endothelial cells in some vessels were also strong positive for Bcl-2mRNA and P53mRNA. Dilation of capillaries and small vessels was lessened. In 21d group, Bcl-2mRNA and P53mRNA expression was decreased in pyramidal cells. In 28d group, little change about the expression and distribution of Bcl-2mRNA and P53mRNA was observed. Lots of Bcl-2mRNA and P53mRNA were scattered in cortex of temporal lobe around hippocampus and callosal gyrus area. Dilation of capillaries and small vessels was lessened obviously. The expression of Bcl-2mRNA and P53mRNA in hippocampus after 16Hz, 90dB infrasound treatment.

次声作用后Bcl-2mRNA和P53mRNA在海马的表达，16Hz、130dB次声作用1d组：两者在海马〓区和齿状回轻度表达，海马内血管轻度扩张；7d组：两者表达在上述区域较1d增多，微血管和小血管扩张较显，血管内皮细胞内可见呈强阳性表达的Bcl-2mRNA和P53mRNA；14d组：海马锥体细胞和齿状回颗粒细胞内Bcl-2mRNA和P53mRNA阳性表达明显增多，呈深兰色，在部分血管内皮细胞内两者强阳性表达，微小血管扩张状态较7d减轻；21d组：锥体细胞胞浆内Bcl-2mRNA和P53mRNA表达减弱；28d组：上述表达及分布与21d组相比无明显改变，海马周围颞叶皮层和扣带回区域亦可见大量散在分布的Bcl-2mRNA和P53mRNA表达，血管扩张状态已明显减轻。90dB次声作用1d-7d后，较对照组无明显变化，14d-21d后轻度表达，28d后，Bcl-2mRNA和P53mRNA表达较强。

When vitamin A effect having stout , lubricating skin , is short of, skin becomes dry , rough; Vitamin B has the fleck effect to extend a wrinkle , removes; Vitamin C may prevent the skin blood vessel from ageing , strengthen blood vessel elasticity , increase white skin, effect cutting down skin chromatosis; Decrease acne the and pigment come into being Wei Sheng Su E , have and resisting the effect old and feeble.

维生素A有强健、润滑皮肤的作用，缺乏时，皮肤变得干燥、粗糙；维生素B有舒展皱纹、消除斑点作用；维生素C可防止皮肤血管老化，增强血管弹性，增白皮肤，减少皮肤色素沉着的作用；维生素E可减少痤疮和色素生成，并有抗衰老作用。

VEGF can specifically increase the dividing, proliferation and movement of endotheliocyte, as well as the permeability of tumor vessels, making it a crucial angiogenic factor in research.

血管的生成机制中，血管内皮生长因子(vascular endothelial growth factor，VEGF)是重要的直接作用于血管内皮细胞的生长因子，可以特异性地促进内皮细胞分裂、增殖、移动，增加血管的通透性，在血管形成中起重要作用，是目前特别受重视的血管生成因子之一。

In this study, human tongue cancer Tca8113 cells and human umbilical venular endothelial cell ECV304 are treated with CPT and the cell proliferation and apoptosis are detected in order to investigate the effect of CPT on Tca8113 and the mechanism of antiangiogenesis.

本研究以喜树碱作用于舌鳞癌细胞(Tca8113)及人脐静脉血管内皮细胞(ECV304)，检测细胞增殖及凋亡状况，以研究喜树碱对舌鳞癌细胞及血管内皮细胞的生长抑制和凋亡诱导作用，探讨喜树碱抗鳞癌的作用及可能机理，并初步探索其抗血管生成机制，为该药治疗皮肤肿瘤和银屑病奠定实验基础。

Our experiment showed that addition of benzydamine induced vasorelaxation in the denuded aorta precontracted with KCl in the normal krebs.

实验结果亦显示，benzydamine能抑制高钾所引起的收缩作用，并且藉由在无钙之Krebs溶液中，经benzydamine前处理的血管给予高钾刺激之后，再给予钙离子刺激血管收缩，发现其能抑制外钙内流所造成的血管收缩作用。

Effects of H_2O_2 on the tension of isolated aortic rings of rat As above methods,Our results indicated that (1) aortic rings with endothelium precontracted by NE to 10000μmol/L H_2O_2 induced a relaxation; aortic rings with endothelium to 100μmol/L H_2O_2 induced a significant contraction;H_2O_2 induced the same effects in aortic rings without endothelium, there is significant difference in presence and absence of endothelium.

双氧水对大鼠离体血管环张力的影响方法同2，结果：①NE预收缩后，加入10000μmol／L H_2O_2，内皮完整血管环表现为舒张作用；加入100μmol／L H_2O_2后血管环表现为收缩作用；H_2O_2对去内皮的血管环同样具有上述作用，与内皮完整组相比差异显著；②10000μmol／L H_2O_2可使得内皮完整及去内皮血管环中NO含量升高；100μmol／L H_2O_2可使得NO含量降低。

The occurrence of this disease with age, body type, environmental factors, the human body skin regulate body temperature and the role of secretion and excretion and in the case of cold, skin vasoconstriction, caused by sweat and sebaceous gland function is low, to prevent the divergence and to reduce skin heat lubrication, while the formation of dry skin, cuticle cracking, scaling, skin inflammation ‥‥ and so on, often associated with soap, disinfectant contact would eliminate the skin of lipids, an increase of the loss of moisture, in addition, can change the skin more dry and older because of the lack of sebum, to reduce sebum secretion, skin showing dry, rough, with a fault in bran-like crumbs off the winter came, the weather is cold, plus hot water bath or multi-use soap, will lead to skin Worse still, dry, itching is also more severe.

本病与年龄，体质，环境因素的发生，人体皮肤调节体温的分泌和排泄和冷，皮肤血管收缩的汗水和皮脂腺功能造成的，作用是低的情况，以防止分歧并减少热量润滑皮肤，而皮肤干燥，角质形成开裂，脱屑，皮肤发炎‥‥等，经常用肥皂联系，消毒剂接触，消除脂质皮肤，一个是水分流失增加，此外，可以改变皮肤更干燥，由于老年人缺乏皮脂，皮脂分泌减少，皮肤干燥显示，在粗糙的麸皮故障，像过冬天屑来了，天气寒冷，加上热热水澡或多用肥皂，会导致皮肤更糟糕的是，干燥，发痒也比较严重。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。