血管作用的

It is a valuable and meaningful direction to study on the effects of NO in the pathogenesis of atherosclerosis.

动脉粥样硬化是严重危害人类健康的疾病，一氧化氮是血管病理的重要介质，探讨NO在AS发病过程中的作用，是一个很有价值和具有重要意义的领域。

Methods: We used cumene hydroperoxide as an inducer of lipid peroxidation to induce the culture ECs lipid peroxidative action and to prepare endothelial cell conditional medium, and then we added it to the merged VSMCs as an experiment factor.

以氢过氧化枯烯为诱发剂引发培养的血管EC的脂质过氧化反应，将制备的内皮细胞条件培养液作为实验因素作用于培养的VSMC。

Object: Cerebral vasospasm constitutes a major complication of subarachnoid hemorrhage. The pathogenesis of cerebral vasospasm is unclear, in spite of intensive investigations conducted over the past years. Even though multiple factors are proposed to be involved in cerebral vasospasm, oxyhemoglobin is one of the most important spasmogens for cerebral vasospasm that fallows aneurismal SAH.

目的：脑血管痉挛是蛛网膜下腔出血后最常见和最严重的并发症，近年来人们对SAH所致脑血管痉挛的发生机制进行了大量的研究，但迄今尚未完全阐明，众说纷纭，甚至有些观点相反，但几乎所有关于脑血管痉挛原因的报告都认为，脑血管痉挛是多种原因造成的，其中氧合血红蛋白是SAH后血管痉挛的主要启动因素之一，它对内皮细胞及平滑肌的细胞毒作用已经被报道。

It has been also demonstrated that lots of some chemical compounds not only have the utility of cancer therapy, but also can reduce the side effects of currently used drugs. Thus, to search for a succedaneum much more effective and easily absorbed by human-body seems to be an appropriate approach to substitute the presently used clinical remedy against cancer.

而在相关研究当中显示，许多抑制血管增生的化合物不仅有抑制肿瘤生长的作用且相对有著较低的副作用，因此寻找有效且容易被人体吸收的化合物用以取代目前临床对於癌症的治疗药物，似乎是比较妥当的方式。

In this topic we detected the expression level of SDF-1,CXCR4,VEGF of the above two malignant hematological tumors as well as their relations to the tumor cell"s characters of drug resistance and infiltration etc, and then elucidated the change of the microenviroment" on the occurrence and development of hematologic tumor. This topic may provide some theoretical and clinical proofs for finding out some new therapeusis to the above two malignant hematological tumors.

本课题旨在通过研究急性白血病和恶性淋巴瘤患者SDF-1、CXCR4、VEGF的表达水平及其与肿瘤细胞迁移、耐药、浸润的关系，阐明骨髓造血微环境和恶性淋巴瘤局部病变微环境的改变在上述血液肿瘤发生发展中的作用及其与血管新生的联系，为从新的角度探索白血病、淋巴瘤的治疗方法提供理论及临床依据。

Second, the different expression between TGF-αmRNA and EGFR mRNA in VSMC stimulated by glucose or glucosamin suggests that maybe there is a mechanism of negative feedback in VSMC which will be benefit to vessels and protect angionosis from acutely deterioration.

二、不同浓度葡萄糖、葡糖胺刺激后VSMC的TGF-αmRNA和EGFR mRNA表达的不一致性提示可能存在负反馈机制，具有一定的保护作用，以防止血管并发症的急剧恶化。

Furthermore, couples of molecules, including Scl, Flk1 and Runx1, are involved in formation and subsequent differentiation of the hemangioblast or hemogenic endothelium during embryonic hematopoiesis.

造血和血管内皮相关分子的表达和调控作用的研究，不仅体现了造血和内皮在发育中的密切关系，同时也加深了对造血发育调控的认识。

Adiponectin is a newly found protein hormone specifically expressed and secreted by adipocytes,and it is the only lipogenic hormone which has protective effection on human.Its protective effection to the vascular endothelium has been widely proved.

脂联素是近年来发现的一种由脂肪细胞特异表达和分泌的蛋白质激素，它是目前惟一发现的对人体有保护作用的脂源性激素，其血管内皮保护效应已被广泛证实。

The results are: 1 the stricture of the capillaries of stria vascularis was observed in most cochleae of rickety rats and, segmental deletions of the outer hair cells on the first turn of cochlea were found in a small number of rickety rats; 2 the perilymphatic ionized calcium concentration significantly re- duced and the threshold of CAP (Compound Action Poten- tials of the eighth nerve) significantly rose in rickety rats in comparison with those of normal control; 3 gentamicin results in an increase of the perilymphatic ionized calcium concentra- tion in rickety rats; 4 the cochleae of the rickety rats appeared to be less vulnerable to the ototoxicity of gentamicin than the normal one.

研究包括两个方面，其一是&佝偻病的感觉神经性耳聋及其对庆大霉素耳毒性作用的耐受性&，系用大白鼠建立维生素D缺乏性佝偻病动物模型，发现：（1）佝偻病大白鼠耳蜗血管纹毛细血管狭窄，少数动物耳蜗底回外毛细胞有节段性缺失；（2）佝偻病大白鼠的耳蜗鼓阶外淋巴钙离子浓度降低，CAP（听神经复合动作电位，以下简称CAP）听阈提高；（3）庆大霉素可使佝偻病大白鼠耳蜗外淋巴钙离子浓度上升；（4）佝偻病大白鼠耳蜗在功能和形态上都比正常者更能耐受庆大霉素的耳毒性损害。

Signalling through CXCR4 mediates actin polymerization and pseudopodia formation in cells, and induces chemotactic and migration to target organs. In addition, CXCR4-SDF-1 axis can promote tumor angiogenesis and growth.

CXCR4在肿瘤组织中的表达明显高于正常组织，而肿瘤常见转移部位均为CXCR4的配体基质细胞衍生因子-1(stromal cell derived factor-1，SDF-1)表达丰富的器官，SDF-1与CXCR4结合后可使细胞肌动蛋白丝聚合，形成伪足，从而定向诱导肿瘤细胞迁移到特定的靶器官；此外，CXCR4与其配体SDF-1相互作用可以促进局部新生血管作用，利于肿瘤生长。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。