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After administration of L-N〓-nitro-Arginine, a specific antagonist of NOS, it was found that the basal and stimulated NO release of blood vessels (aorta, internal carotid, renal and mensenteric artery) was decreased further. The increase of coronary blood flow stimulated by Ach was also reduced further, while the platelet aggregation degree and erythrocyte aggregation index increased significantly. Pathological examination indicated that aortic endothelium was destroyed, the blood vessels in cerebral, cardiac and renal tissues were hypertrophied further and some were almost occluded. The above fin dings resulted in SHR feeded with L-NNA having high incidence of stroke rate and high degree of renal cirrhosis when compared to control SHR. The infarct and hemorrhagic focuci in cerebral tissues, infarct focuci in cardiac tissues, atrophy and hyalinedegeneration of renal glomeruli and degeneration even necrosis of renal tubuli in renal tissues were al so found. The increase ratio of brain and heart to body weight and decrease ratio of kidney to body wei ght further demonstrated that the cerebral, cardiac and renal injuries were aggravated.

在上述结果的基础上进一步给予SHR NOS特异性拮抗剂左旋亚硝基精氨酸后,血管(胸主、颈内、肾及肠系膜动脉)NO基础释放及激动剂刺激释放进一步减少,Ach刺激冠脉流量的增加和胸主动脉内膜NOS活性也进一步减少,血小板聚集程度及红细胞聚集指数显著上升,病理切片显示胸主动脉内皮细胞破坏明显,脑心肾组织内的血管进一步增厚甚至几乎阻塞,导致饲L-NNA的SHR缺血性及出血性脑卒中发生率显著高于对照SHR,脑体重比显著升高;心肌内出现明显的缺血梗塞疤痕灶,心体重比显著升高;肾小球明显萎缩、玻璃样变性,肾小管也变性甚至坏死,使肾硬化程度显著增加呈颗粒性固缩肾,肾体重比也显著减少。

Immunofluorescence assay was used to detect endothelial cell uptake and absorption acetylated low density lipoprotein and ulex europaeus agglutinin-Ⅰ. EPCs quantitative detection of surface markers was performed by flow cytometry: CD133, CD34 antigen expression and KDR.

通过免疫荧光法观察内皮细胞吸收乙酰化低密度脂蛋白和荆豆凝血素Ⅰ情况,流式细胞仪定量检测血管内皮祖细胞表面CD133、CD34和KDR抗原表达阳性率来鉴定血管内皮祖细胞。

The biological characteristics of the CCM are mainly relevant to the unmaturity of the vessel wall. A series of angiogenic factors play an important role in the development of the lesion. The proliferative activity of the CCM needs to be studied further. The different clinical presentations of CCM was based on its pathological diversity.

CCM生物学特性主要与其血管壁组织结构的不成熟有关,各种血管因子发挥了相当重要的促进作用,CCM本身的增殖活性有待进一步研究;CCM不同的临床表现与其病理特点的差异密切相关。

After three weeks, animals were randomly divided into four groups:(1)diabetic rats received intensive insulin therapy for 20 days;(2)diabetic rats received unregular insulin therapy, which caused the abrupt fluctuation of glycemic level;(3)diabetic control rats; and (4)normal control rats.

中文摘要:目的观察胰岛素治疗对糖尿病大鼠视网膜血管内皮细胞生长因子(vascular endothelial growth factor, VEGF)和血管生成素-2(angiopoietin-2, Ang-2)表达的影响,探讨胰岛素在糖尿病视网膜病变发生发展中的作用。

The results showed that though testosterone or 17-β-estradiol did not affect the expression of these AM in unstimulated HUVEC, both of them transiently increased the expression of E-selectin and VCAM-1 in TNF-α-stimulated HUVEC.

近几年研究发现,粥样硬化与炎症及免疫反应有关,TNF-α等细胞因子可以通过刺激血管内皮细胞粘附分子的表达及血管平滑肌细胞的增殖等而在粥样硬化的形成中起重要作用。

The significance was showed by the chisquare test (P.005);(2) The conventional MRI demonstrated that positive sign was 50.9% on the symptomatic side and 6.1% on the unsymptomatic side.

有三叉神经痛症状的一侧血管接触、压迫神经的比率明显高于非疼痛侧,其阳性率差异有显著意义(P.005);(2)MRI常规扫描发现有三叉神经痛症状的一侧血管压迫神经阳性率50.9%,非疼痛侧阳性率6.1%。

Purpose: The aims of this study are (1) to evaluate the spatial distribution of neovessels and mature vessels in human uveal melanoma tumors and (2) to determine whether vessel maturation is associated with the major indicators for poor prognosis.

目的:此项研究的目的是:(1)评估人葡萄膜黑色素瘤的新生及成熟血管的空间分布(2)明确血管成熟是否与预后差的主要标志物有关。

She is especially good at the management of the eyeground diseases, such as ocular fundus bleeding from various reasons, retinal vascular diseases (such as diabetic retinopathy, retinal vein occlusion, retinal artery occlusion, retinal vasculitis etc.) from diabetes mellitus, hypertension, or various inflammation, retinal capillary hemangioma, vitreous hemorrhage caused by various retinal diseases, optic neuritis, ischemic optic neuropathy, retinal detachment, macular diseases (such as age related macular degeneration, central serous chorioretinopathy, central exudative chorioretinopathy etc.), and other complex diseases such as uveitic diseases and glaucoma etc.

特别是对眼底病如各种原因所致眼底出血;糖尿病、高血压、各种炎症所引起的视网膜血管病如糖尿病视网膜病变、视网膜静脉阻塞、视网膜动脉阻塞、视网膜血管炎症等;视网膜血管瘤病以及其他各种视网膜病所致玻璃体出血;视神经炎、视神经缺血、视网膜脱离、黄斑部疾病如老年性黄斑变性、中浆、中渗等及其他疑难病如葡萄膜炎,青光眼等的诊治积累了大量的临床经验。

In nude mice, large and invasive tumors were found after injection of HuH7 cells subcutanesously. While mice injected with SeLT cells demonstrated highly vacuolated cells-filled tissue masses, severe necrosis, 4 inflammation as well as degenerated blood vessels.

利用皮下注射肝癌细胞株到裸鼠之后,实验发现HuH7 形成较大的肿瘤、有大量的血管形成且有转移的现象,而SeLT 虽然能够形成tissue mass 但其中大部分的细胞都有严重坏死及发炎的现象产生,伴随著新血管也呈现有萎缩的现象。

The effects of vacuolization on the differentiation of vascular endothelial cells were analyzed from a chemical biochemistry genetics perspective using the blastodisc cells differentiation model induced by FGF with the γ-butyrolactones derivative.

从化学遗传学的角度,利用γ-丁内酯衍生物研究了成纤维细胞生长因子(fibroblast growth factor, FGF)诱导鸡胚盘细胞向血管内皮细胞分化过程中,空泡化对血管内皮细胞分化的影响。

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According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm~150rpm时取得最大值,此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世,形体几无变化。

When I was in school, the rabbi explained everythingin the Bible two different ways.

当我上学的时候,老师解释《圣经》用两种不同的方法。