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Christopher Skelly, MD, assistant professor of vascular surgery at the University of Chicago Medical Center, and the study's lead author says, One of the drawbacks of balloon angioplasty to open blocked arteries and the use of stents to keep them open is that arteries sometimes experience aggravation from the procedure.

Chicago大学医学中心血管外科助理教授Christopher Skelly是此项研究的主要负责人,他说:利用气囊或是支架进行的血管成型术一般用于打开封闭的血管,但是它们可能会带来副作用,使病情加重。

VEGF can encourage vascular endothelial cell to divise、propagate、migrate, and add vasopermeability, facilitate producing vascellum sustentaculum, to profit blood supply in ischemic region.

血管内皮生长因子能促进微血管内皮细胞分裂、增殖、迁移,增加血管通透性,促进血管支持物的生成,有利于缺血区血液的供应。

During each stage of angiogenesis, there are many different factors that take action synergically in temporal and spatial manner to the ongoing of vessel formation.

血管生成,即从原有血管生发出新的血管的过程,是体内最为基本和重要的过程,也是维持机体稳定性与完整性以及组织和器官功能的重要方式。

During each stage of angiogenesis, there are many different factors that take action synergically in temporal and spatial manner to the ongoing of vessel formation. Accorrding to their attribution to angiogenesis, these factors can be generally divided into positive and negative regulating factors.

血管生成的各个阶段,有多种因子在时间和空间上协同作用,共同调节血管生成的进行,大体上可将这些调节因子分为正性调节因子和负性调节因子,正负调节的总体平衡决定着血管生成过程的启动与关闭。

At 4 wk, the cells in the liver bud migrated into the domain of transversum mesenchyme, where endothelial cells began to form vascular structures, and branched to form a number of hepatic cords.

结果:3wk时靠近肝芽的间充质中的血管内皮细胞多,而肝芽内未见血管内皮细胞及造血细胞:4wk时,肝索形成处可见较多正在形成的新生血管增多,肝索间开始出现少量的造血细胞:5wk时肝索间出现原始的肝血窦结构,血窦内造血细胞的数量较4wk明显增多。

BACKGROUND: Although angiography is the gold standard for the diagnosis of cerebrovascular disease, it cannot be used widely because of its traumatotaxis. Transcranial Doppler ultrasound and MRA are both non-invasive examinations, which can be used to evaluate intracranial large artery vascular trunks and hemodynamics.

背景:血管造影虽为诊断脑血管病的&金标准&,因其有创性不能广泛应用,经颅多普勒超声和头部磁共振血管成像均为无创检查,可用于颅内大动脉血管腔及血流动力学的评估。

T739 mice were inoculated with LA795 cells. Angiostatin was given to part of inoculated and uninoculated mice by intraperitoneal injection fourteen days after the inoculation. The treatment lasted 20 days and the size of tumor, survival period, behavior of the mice and pathology of lungs, livers and kidneys were observed.

用亲和层析方法得到的血浆纤维溶酶原经胰蛋白酶消化、层析柱亲和层析、透析,得到纯化的血管抑素;以LA795细胞接种于T739小鼠;接种后第15日起腹腔内注射血管抑素共20 d,观察动物行为,测量荷瘤鼠肿块直径,记录生存期,另设未治疗对照组及观察血管抑素副作用对照组,行肺、肝、肾脏病理学检查。

Methods Affinity chromatography purified plasminogen was digested by pancreatic elastase and angiostatin was obtained by purifying the digestion with affinity chromatography and dialysis. T739 mice were inoculated with LA795 cells. Angiostatin was given to part of inoculated and uninoculated mice by intraperitoneal injection fourteen days after the inoculation. The treatment lasted 20 days and the size of tumor, survival period, behavior of the mice and pathology of lungs, livers and kidneys were observed.

用亲和层析方法得到的血浆纤维溶酶原经胰蛋白酶消化、层析柱亲和层析、透析,得到纯化的血管抑素;以LA795细胞接种于T739小鼠;接种后第15日起腹腔内注射血管抑素共20 d,观察动物行为,测量荷瘤鼠肿块直径,记录生存期,另设未治疗对照组及观察血管抑素副作用对照组,行肺、肝、肾脏病理学检查。

After bilateral dissection of internal and external iliac vessels, the transplanted uterus was placed in orthotopic position, the cervix was sutured to the vaginal vault, uterosacral ligament was reconstructed and extended, uterine vessels were anastomosed to respective external iliac veins and arteries.

经过清理双侧髂内血管和髂外血管,移植的子宫被放置在原来的正常位置。医生对患者的子宫颈与阴道穹窿进行了缝合,又重建并延伸了子宫骶韧带,同时将子宫血管分别与髂外静脉和髂外动脉进行缝合。

RESULTS: TEM displayed normal morphology of EC, its conjunction, SMC and intimal elastic lamina in control group, while in SAH group, marked pathological changes were observed, including desquamation and dystrophy of ECs, disruption of tight junction, vacuolated cytoplasm, condensation of chromatin in ECs, corrugation of IEL, and distortion of SMC.

结果: 电镜下,对照组血管壁超微结构无变化;SAH组电镜下血管内皮层结构以及内皮层细胞结构发生严重变性改变;用药治疗和预防组电镜下各组之间血管超微结构的改变无明显差异,组织变性程度明显轻于SAH组。

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