血清病

Clinical Efficiency of Meningococcus Group A Capsular Polysaccharide Vaccine in Children Three Months to Five Years of Age Cellular and Humoral Components of Monocyte and Neutrophil Chemotaxis in Cord Blood Oral non-absorbed Antibiotics Prevent Infection in Acute non-lymphoblastic Leukemia Aspirin-induced Hepatotoxicity and Its Effect on Juvenile Rheumatoid Arthritis Prediction of Morbidity in Hemophilus Influenzae Meningitis Neurological Sequelae in Children Surviving Mechanical Ventilation in the Neonatal Period Developmental Effects of Prolonged Pregnancy and the Postmaturity Syndrome Long-term Outcome of Hemophilus Influenzae Meningitis Related to Antibiotic Treatment Recommendations for a National Policy on Poliomyelitis Vaccination Impaired Humoral Immunity in Treated Hodgkin's Disease Development of Immune Response during Typhoid Fever in Man In Vitro Susceptibility of Recently Isolated gram-negative Bacteria to Gentamicin, Sisomicin, Tobramycin, and Amikacin Studies of Urticaria and Acute Serum Sickness with the CI Precipitin Test Epidemic Measles in a Highly Vaccinated Population Congenital Chloride Diarrhea Acute Parotitis Associated with Influenza, Type A: Twelve Cases Urinary Tract Infection in high-risk Newborn Infants Maternal ABO Blood Group Type B: A Risk Factor in the Development of Neonatal Group B Streptococcal Disease

脑膜炎双球菌A羣被囊多醣类疫苗接种在3个月到5岁大小孩之临床效果脐带血内单核球及嗜中性球化学向性之细胞成分及体液成分口服不被吸收的抗生素可预防性急非淋巴球性白血症病人罹患感染阿斯匹灵引起之肝毒性及其对幼年性风湿样关节炎之影响流行感冒杆菌脑膜炎预后之预测新生儿时期接受人工呼吸器其日后神经系统上之后遗症过期妊娠及过度成熟徵候对发育之影响流行感冒杆菌脑膜炎之长期预后与抗生素治疗之关系对"小儿麻痹预防接种的国家政策"的建议 Hodgkin's disease治疗后体液免疫之缺损伤寒患者免疫反应的研究目前分离出来的革兰氏阴性菌在体外对Gentamicin，Sisomicin，Tobramycin和Amikacin之感受性荨麻疹和急性血清病CI沉淀素试验的研究在大多数接种人羣发生的麻疹流行先天性氯腹泻与influenza A型病毒有关的急性腮腺炎：12病例报告高危险性新生儿的尿道感染母亲血型B型：为新生儿发生B羣链球菌疾病之个危险因素

ObjectiveTo study the pharmacological actions of Jinyingzi on acute experimental serum sickness nephritis model rats.

目的研究金樱子醇提物对血清病型肾炎大鼠的药理作用。

Shenhua Tablet is effective in treating this modified rat chronic serum sickness glomerulonephrits.

经过改良的模型制作方法可以显著提高慢性血清病肾炎模型的成功率。

The main pathology change in chronic serum sickness is immunocomplex deposition and imrnflammatory cell infiltration, and Stat3 singaling is an important pathway for cytokines, so StatS may be activated in this model.

慢性血清病肾炎主要的病理改变是肾小球内免疫复合物沉积及炎细胞浸润，很可能会引起细胞因子重要的信号转导途径Stat3通路的活化，产生致病作用。

It can reduce the expression and activation of Stat3 in kidney tissue of chronic serum sickness glomerulonephrits rats, which might be one of the mechanisms of its effectiveness in treating nephritis.

中药肾华与西药福辛普利进行比较，对大鼠改良慢性血清病肾炎模型有良好的降低蛋白尿、升高血清白蛋白、减轻病理变化、减少免疫复合物沉积等治疗作用，而其降低大鼠慢性血清病肾炎模型肾组织内Stat3表达及活化，可能是其减轻肾炎病变程度的机制之一。

Staphylococcal protein A ; Immune complex ; Acute experimental serum sickness ; Glomerulonephritis

葡萄球菌A蛋白；免疫复合物；急性实验性血清病；肾小球肾炎

Immunologic conditions that cause lymphadenopathy can be secondary to clearly identified antigens, as in serum sickness, or a response to an insect bite, or the lymphadenopathy may be secondary to antigenic stimulation in conditions where the antigen has not been identified.

导致淋巴结病的免疫条件可继发于明确的抗原，如在免疫复合物血清病、动物咬伤的反应或继发于抗原不明的抗原刺激。

Since the success rate of traditional chronic serum sickness in rat is low and thus difficult to be used in therapeutic effects observing, we firstly improved its founding methods , and then used it to observe the effect of Shenhua Tablet compared with Fosinopril.

由于传统慢性血清病肾炎模型成功率较低，造成观察药物疗效的困难，因此本研究首先探索了提高慢性血清病肾炎模型成功率的改良措施，然后利用该改良模型以福辛普利为对照从24h尿蛋白定量、血生化指标、肾功能变化及肾组织病理学改变等方面观察中药肾华的疗效。

In order to prove if staphylococcal protein A can clear immune complexes from rabbit plasma with Acute Experimental Serum Sickness and play a role in the improvement of glomerulonephritis, the animals were randomly divided into two groups(14 each), experimental and control.

为了证实葡萄球菌A蛋白是否能除去急性实验性血清病家兔血浆中免疫复合物以减轻肾小球肾炎的病变，本实验设实验组和对照组，每组家兔各14只。实验组於注射抗原后第8、10、12天抽血14ml/kg体重，分离血浆以金葡球菌Cowan Ⅰ株处理后，再将血浆与血球混匀输回原家兔体内；对照组家兔血浆以金葡球菌Wood 46株处理后，再将血浆与血球混匀输回原家兔体内。

Methods: The traditional method of chronic serum sickness was modified by adding followings: one kidney removed, intraperitoneal inject LPS etc., and the effect of Shenhua Tablet on 24h proteinuria, blood biochemical indices, kidney function, pathology and immunofluorescence changes was observed compared with Fosinopril, and and the effect of Shenhua Tablet on the ED-1 positive cell number in the glomerulus, protein and mRNA expression and activation of Stat3 and protein and mRNA expression of TIMP-1 in the kidney tissue, and a-SMA positive mesangial cells were observed compared with Fosinopril using western blot, northern blot and immunohistochemistry methods.

对传统的大鼠慢性血清病肾炎模型制作方法进行以下改良：切除大鼠一侧肾脏、腹腔注射大肠杆菌内毒素、以及改尾静脉注射为腹腔注射。与西药福辛普利作对照，观察中药肾华对改良慢性血清病肾炎大鼠尿蛋白、血生化、肾功能、肾脏病理变化的影响。并通过免疫组化、Western蛋白印迹及Northern杂交方法，观察中药肾华对改良慢性血清病肾炎大鼠肾组织肾小球内炎细胞浸润、Stat3蛋白与基因表达及活化、以及其下游调控的TIMP-1蛋白与基因表达、系膜细胞增殖的影响。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。