血液学

Gelsemium total alkaloids improved some blood and immune function of mice when it less than 0.30mg/kg body weight, but more than 1.5mg/kg body weight, the gelsemium total alkaloids can reduced some blood and immune function of mice; below the dose of 3%, GEB"s power can improve some blood and immune function of broilers, but GEB"s power can reduce some blood and immune function of broilers above the dose of 6%.

结论是：钩吻对小鼠和肉鸡的血液学及免疫功能的影响均存在着剂量差别，钩吻总碱稀释液在0.30mg／kg剂量以下，能够提高小鼠的某些血液指标与免疫功能(p＜0.05)，而在1.5mg／kg以上，则降低小鼠的某些血液指标与免疫功能(p＜0.05)；3％以下的钩吻干粉能够提高肉鸡的某些血液指标与免疫功能，而6％以上的钩吻干粉则降低某些血液指标与免疫功能。

We demonstrated the effect of the gelsemium total alkaloids of on blood and immune function of three different doses (0.15mg/kg,0.30mg/kg,1.5mg/kg) on mice and dieted with three GEB powers contents(1.5%,3%,6%) on chicken . The results showed as follow:1.The gelsemium total alkaloids of 0.15mg/kg,0.30mg/kg doses increased RBQHB, percentage of ANAE+ lymphocytes, phagocyty of peritoneal macrophage of mice.

本研究探讨了不同剂量(0.15mg／kg、0.30mg／kg、1.5mg／kg)的钩吻总碱稀释液对小鼠的血液学与免疫功能的影响，以及不同日粮添加水平(1.5％、3％、6％)的钩吻干粉对肉鸡血液学与免疫功能的影响，结果表明： 1、灌胃0.15mg／kg、0.30mg／kg剂量的钩吻液，能够提高小鼠红细胞数、血红蛋白含量、外周血ANAE~+淋巴细胞数、腹腔巨噬细胞吞噬指数及吞噬百分率。

Methods: the toxicity reaction and impaired degree after intraperitoneally injecting scu were observed by detecting indexes of hematology, hematological biochemics and pathohistology.

通过血液学、血液生物化学和病理组织学检查，观察scu对大鼠的毒性反应及程度。

In the long-period toxicity test, DCG was administered repeatedly for 60 days, the dose were 72.6,36.3,18.2 g/kg respectively(It refered to the dose of material,which amounted to 52.6,26.3,13.2 times of 50 kg human clinic use). There is no other abnormal changes about color patem,action,urine and stool,but cibation, hydroposia, body weight and index part of hematological and hematobiochemical parameters,coefficient and histomorphological figure of organs were examined during administration phase.The rats were examined in 21 days after the cessation of DCG, the abnormal changes of index was completely recovered.

定喘颗粒大鼠给药60 d的毒性试验，剂量分别为72.6，36.3，18.2 g/kg（相当于临床50 kg人用量的52.6，26.3和13.2倍），给药期间各组大鼠毛色、活动、二便均无异常变化，但给药组大鼠摄食、饮水、体重以及部分血液学、血液生化学指标和脏器系数有异常变化，停药后，上述异常变化指标均已恢复正常。

Methods The mice were intragastrically administered with Wikstroemia Liquid for 90 days continuously. The doses of Wikstroemia Liquid were 60 times, 30 times, 15 times as human daily doses. The mice condition, major hematological indexes, blood biochemical and organ pathological tissues changes were observed during medicine administration, at the end of medicine treatment and resuscitation stage after medicine treatment.

取复辣液分别相当于人日用量的60倍、30倍、15倍，经90天小鼠灌胃给药，观察给药过程中、给药末期及停药恢复期动物的一般状况，主要血液学、血液生化学和脏器病理组织变化。

Methods: One hundred and sixty SD rats were randomly divided into four groups （40 in each group）, and orally given the medicine with doses of 50, 25, or 12.5 g/kg of crude drug, or with bean oil of 0.5％CMC-Na daily for 26 weeks.The physical status （body weight,growth rate and appetite）, hematological parameters, blood biochemistry, blood cotting, organ index, and tissue pathological changes of rats were checked in the 13th week,and 26th week of the administration and in four weeks after the stop of the administration.

160只SD大鼠，随机分为高、中、低剂量组及空白对照组，雌雄各半，每日灌胃1次，连续给药26周，观察大鼠的一般状况、体重、摄食量和给药13、26周及停药后4周大鼠的血液学、血液生化学、凝血功能、脏器系数、解剖学及病理组织学改变的情况。

The physical status （body weight,growth rate and appetite）, hematological parameters, blood biochemistry, blood cotting, organ index, and tissue pathological changes of rats were checked in the 13th week,and 26th week of the administration and in four weeks after the stop of the administration.

160只SD大鼠，随机分为高、中、低剂量组及空白对照组，雌雄各半，每日灌胃1次，连续给药26周，观察大鼠的一般状况、体重、摄食量和给药13、26周及停药后4周大鼠的血液学、血液生化学、凝血功能、脏器系数、解剖学及病理组织学改变的情况。

Results The outer appearance and behavior, weights, organ coefficient, the indexes of haematology and biochemistry in rats had no significant difference by comparing with control group.

复方银杏叶片88.44， 17.69 mg /kg（为临床日剂量的50倍和10倍）给大鼠连续灌服13周，停药2周，分别测量大鼠体重，计算脏器系数，测定血液学和血液生化学指标，并作组织病理学检查。

ResultsThe outer appearance and behavior, weights, organ coefficient, the indexes of haematology and biochemistry in rats had no significant difference by comparing with control group.

方法复方银杏叶片88.44， 17.69 mg /kg（为临床日剂量的50倍和10倍）给大鼠连续灌服13周，停药2周，分别测量大鼠体重，计算脏器系数，测定血液学和血液生化学指标，并作组织病理学检查。

Results Various side effects resulting from antituberculous agents were confirmed in 302 cases (32.7%),liver injury,acoustic nerve injury, blood system injury, gastrointestinal response of them were primary (82.1%).Stopped treatment rate was 14.6%.77% in side effects occurred within 2 months after administration, but the blood system injury occurred after 3 months.

结果：抗结核药物副作用302例(32.7%)，以肝损害、位听神经损害、血液学异常及胃肠反应为主(82.1%)，因副作用致终止治疗率14.6%。77%的副作用出现于给药的2个月内，血液学异常的50%以上在用药的3个月后出现。

By the time of its fall, most of the prisoners were writers who had written against the corruptions of the government.

到它被攻陷的时候，里面多数的犯人是写了反对政府贪污文章的作家。

The most obvious variation to ovum morphological character was that the color was changed from light green to sepiaceous in embryonic development, and all the ovums were almost hatched after 96h.

在胚胎发育过程中卵的形态特征最明显的变化是颜色从淡绿到深褐色，卵在发育96h后卵基本全部孵化。