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血浆减少

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It can be said thatblood stasis is the main pathology of DN,which is in line with Chinese medicine in "invalidism must accompany with blood stagnation""invalidism develop into collaterals" The view of blood stasis also match the modern medical point of hemodynamics changes and capillaries disease in patients with DN,such as increased hemorheology general index,blood viscosity and lipids, reduced kidney blood flow,platelet aggregation,sclerosis of blood vessels, renal microcirculation disturbance,even hypercoagulability.

可以说,瘀血阻络是糖尿病肾病的主要病机,这既符合于中医"久病必瘀""久病入络"的学术观点,也与现代医学认识的糖尿病肾病患者血液动力学和肾脏微血管病理学实验中,血液流变学的指数普遍升高、血浆粘度增加、血脂增高、肾血流量减少,血小板聚集、血管硬化,肾微循环障碍,甚至出现高凝状态的研究相当吻合。

Methods By a monoclonal antibody immobilization of platelet antigen assay, antiplatelet autoantibodies were detected using monoclonal antibodies specific for glycoproteins Ⅰb,Ⅱb/Ⅲa and P-selectin in patients with ITP and nonimmune thrombocytopenia. Meanwhile, RP% and PAIgG were measured in the same samples with flowcytometry.

通过改良的单克隆抗体特异性捕获血小板抗原试验测定ITP(86例)与非免疫性血小板减少(30例)患者血浆中血小板膜糖蛋白Ⅰb、GPⅡb-Ⅲa以及P-选择素自身抗体,同时以流式细胞术检测相应的RP%及PAIgG。

The results show that after lone- term load swimming training, the CEC was increased, the plasma ET content was increased and serum NO content was desreased; endothelium ultrastructure was damaged; tragacanth makes the CEC was decreased After large load exercise, the plasma ET content was decreased and serum NO was content was insreased; endothelium ultrastructure was improved.

结果表明:①大运动量运动训练后,大鼠CEC增多,血桨ET含量上升,血清NO含量下降;内皮细胞结构受损。②黄芪使大鼠大运动量训练后CEC减少,血浆ET下降,血清NO含量升高;内皮细胞超微结构改善。

The levels of plasma adrenocorticotropic hormone and cortisol were measured by radioimmunoassay.

结果:与正常组比较,模型组大鼠体重增加缓慢,敞箱实验中的水平运动、垂直运动得分、理毛次数显著减少,中央格停留时间显著延长,糖水偏爱度明显下降,且其血浆CORT和ACTH含量增加。

Hemostatic mechanism total saponins of Yinfenglun were studied on plasma recalcified time, FT, KFTT and ELT. Result: TSY at different doses could markedly shorten bleeding time, reduce bleeding volume in mice. TSY also could shorten clotting time of mouse, rat and dog. TSY could influence both intrinsic coagulatian system and extrinsic coagulatian system, and had no effect of antifibrinolysis.

结果:荫风轮总苷不同剂量可明显缩短小鼠断尾出血时间,减少出血量,并能缩短小鼠、大鼠、犬凝血时间;可明显缩短家兔血浆复钙时间、凝血酶原时间和白陶土部分凝血活酶时间,但对大鼠优球蛋白溶解时间无明显影响,表明荫风轮总苷既能影响内源性凝血系统,又能影响外源性凝血系统。

Vascular hyperpermeability is one of the important causein hypovole-mia and organs disfunction after various kinds of shock,and its treatment is still one of the problems in the medical field. For example,the operative methods of preventing hyperpermeability and plasm bleeding is still unreliable after severity burn,and traditional treatment just passively transfuses according to the burn clysis formula instead of inhibiting permeability by injecting drugs. The principal reason is that pathogenesis of vascular endothelial cell permeabilty has not been entirely revealed at the level of molecular biology.

血管通透性增高是休克时有效血容量减少和器官功能损害的重要原因之一,它的防治一直是医学界的一个难题,如在大面积烧伤时,至今未能找到一个简单有效的防治血管通透性升高和血浆渗出丢失的方法,传统的方法只是根据烧伤补液公式测算进行被动的补液来纠正,而不能依靠注射化学制剂来终止其渗出,主要原因是未能从分子生物学水平揭示血管内皮细胞渗出的机制。

Ningnaotang have curative effects on cerebral edema at the Acute hemorrhagic Apoplexy Stage.So the dosis and the side effect of mannit were decreased. Ningnaotang has an effect on the content changes of CRP and FIB, the state of illness of the patients with acute cerebral hemorrhage. This investigation show Ningnaotang is helpful to the prognosis and curative effect for patients with acute cerebral hemorrhage

宁脑汤对急性出血性中风患者的脑水肿有减轻作用,可以减少甘露醇的用量,从而降低了甘露醇的副作用,并且对血浆纤维蛋白原和C-反应蛋白含量变化及病情有影响,故使用宁脑汤有助于改善急性出血性中风患者的预后和疗效。

Having treated with sodium nitroprusside,the patients got an increase of the brachial...

硝普钠可明显改善高血压患者肱动脉的顺应性,其机制除涉及NO的生成外,可能还与血浆ANGⅡ的减少有关。

LDL of serum in healthy person was separated by improve precipitate method.Results:Pae(300,150 mg.kg-1)could reduce significantly the levels of MDA of serum,aorta and liver;Pae(300 mg.kg-1)decreased obviously the content of OX-LDL of plasma;Pae1 000,200,40 μg.ml-1refrained markadly the course of oxidational decorate of LDL of serum in healthy person.

结果:Pae(300,150 mg.kg-1)可明显抑制高脂大鼠血清、主动脉及肝脏脂质过氧化反应;Pae(300 mg.kg-1)显著减少高脂大鼠血浆LDL的氧化修饰;Pae(1 000,200,40 μg.ml-1)对健康人血清LDL的体外氧化反应有极显著抑制效应。

Objective To investigate the significance of plasmic solubility selectins in invasion of puerile ITP.

目的探讨血浆可溶性选择素在儿童特发性血小板减少性紫癜发病中的意义。

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