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Aim To investigate the in vitro and in vivo stability of 9-nitrocamptothecin lactone form in rat plasma.

目的 考察9-硝基喜树碱内酯型在大鼠体内和离体大鼠血浆中的稳定性。

By using of this method, the ratios of lactone form to the total in rat plasma at different time were determined in vitro and in vivo.

结果 9-硝基喜树碱内酯型在大鼠体内的稳定性显著优于体外,在体外全血中的稳定性显著优于血浆

Methods The plasma levels of Fib and CRP of 86 cerebral infaction patients, 27 lacuna cerebral infarction patients and 48 health adults were measured.

检测86例脑梗死患者、27例腔隙性脑梗死患者和48名健康人的血浆Fib及CRP含量。

The rise of Hcy in plasma is a risk factor for cerebral thrombosis and lacunar infarction.

血浆Hcy水平升高是脑血栓形成及腔隙性脑梗死的危险因素。

Methods There were 100 patients with acute cerebral infarction, 22 cases of large area infarction, 36 cases of small area infarction, 42 cases of lacunar infarction.

目的 探讨急性脑梗死患者血浆组织型纤溶酶原激活物及其抑制剂1(PAI1)水平的动态变化及其与梗死面积的关系。

But noactivity was detectable in plasma after laminarin injection.

本实验还首次利用蛋白质组学技术对2D凝胶上的精氨酸激酶成功进行了鉴定,并发现在海带多糖注射后 45min的血浆中精氨酸激酶是变化最明显的蛋白之一。

The present study determined the effect of laudanosine on the minimum alveolar concentration of halothane and the influence of different inhaled anesthetics on the plasma concentration-seizure effect relationship for laudanosine in rabbits.

本文研究了Laudanosine在家兔中的药物代谢动力学及其对家兔氟烷MAC的影响,观察了几种常用吸入麻醉剂对家兔Laudanosine致惊厥血浆阈浓度的影响。

To determine the effect of anesthetic agents on the plasma concentration of laudanosine that produces seizure activity, the author administered laudanosine by i. v. infusion to rabbits with 7 different regimens.

家兔按Wagner氏双速率法静脉点滴Laudanosine溶液使血浆浓度达200,400,800ng/ml左右时,其氟烷MAC较对照(1.08±0.28%)分别增高8,22和30%左右,但无惊厥体征或脑电变化出现。

Plasma levels of atracurium and laudanosine were determined by high-performance liquid chromatography and the concentra- tion-time data were analized pharmacokinetically and pharma- codynamically with software package of MCPKP and Sheiner's principle respectively.

本文以高效液相色谱法测定血浆阿屈宁和Laudanosine浓度,分别以MCPKP软件和Sheiner氏药物效应学模型行药物代谢动力学和药物效应动力学分析。

Although the clinical experience and the results of animal experiments indicate that the adminis- tration of atracurium at recommended doese is unlikely to result in laudanosine concentrations capable of producing seizure activity, Hennis et al found that at a plasma concentration below that causing convulsions, laudanosine "awaken"dogs lightly anesthetized with halothane.

临床病人应用常用剂量阿屈宁后,血浆Laudanosine选低于使动物发生惊厥所需的浓度,数百万例应用阿屈宁的病人中也未见有因代谢生成之Laudanosine而发生惊厥体征或脑电征象者。可以认为,阿屈宁的临床应用是不会因Laudanosine的生成而引起惊厥的。

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