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血小板

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He was previously healthy until 2000 when he developed petechiae and purpura on both legs. In 7/2000, he was diagnosed with thrombocytopenic purpura (platelets 36×10*9/l, but normal WBC/Hgb/LFTs/renal function/urinalysis).

他一直很健康,2000年的时候突然发现两条腿上有血瘀点和紫癜。2000年7月,他被诊断患有血小板减少性紫癜(血小板数,36×10*9/l,但是白细胞/血红蛋白/肝功能试验/肾功能/尿检均正常)。

There is controversy as to whether prophylactic platelet transfusions are necessary or beneficial, although it seems that maintaining a platelet count of greater than 5,000, and sometimes higher, reduces the risk of minor bleeding (e.g., nose bleeds, bruises in the skin called ecchymoses, pinpoint bleeding in the skin called petechiae).

虽然把血小板计数维持在5000以上似乎能够减少小出血的风险(比如,流鼻血,皮肤的瘀斑以及小瘀点),但是人们对于预防性输注血小板的必要性及好处仍存有分歧。

There is controversy as to whether prophylactic platelet transfusions are necessary or beneficial, although it seems that maintaining a platelet count of greater than 5,000, and sometimes higher, reduces the risk of minor bleeding (e.g., nose bleeds, bruises in the skin called ecchymoses, pinpoint bleeding in the skin called petechiae).

虽然把血小板计数维持在5000以上似乎能够减少小出血的风险(比如,流鼻血,皮肤的瘀青以及小瘀点),但是人们对于预防性输注血小板的必要性及好处仍存有分歧。

There is controversy as to whether prophylactic platelet transfusions are necessary or beneficial, although it seems that maintaining a platelet count of greater than 5,000, and sometimes higher, reduces the risk of minor bleeding (e.g., nose bleeds, bruises in the skin called ecchymoses, pinpoint bleeding in the skin called petechiae).

虽然使血小板计数维持在5000或以上似乎能够降低轻微出血的风险(比如流鼻血、皮肤的瘀斑、瘀点),但是对于预防性血小板输注的必要性及益处仍存有分歧。

There is controversy as to whether prophylactic platelet transfusions are necessary or beneficial, although it seems that maintaining a platelet count of greater than 5,000, and sometimes higher, reduces the risk of minor bleeding (e.g., nose bleeds, bruises in the skin called ecchymoses, pinpoint bleeding in the skin called petechiae).

虽然使血小板计数维持在5000以上似乎能够减少轻微出血的风险(比如,流鼻血、皮肤的瘀斑及小瘀点),但是人们对于预防性输注血小板的必要性及好处仍存有分歧。

There is controversy as to whether prophylactic platelet transfusions are necessary or beneficial, although it seems that maintaining a platelet count of greater than 5,000, and sometimes higher, reduces the risk of minor bleeding (e.g., nose bleeds, bruises in the skin called ecchymoses, pinpoint bleeding in the skin called petechiae).

虽然使血小板计数维持在5000以上似乎能够减少轻微出血的风险(比如流鼻血、皮肤的瘀伤及微小出血),但是对于预防性输注血小板是否必要以及这样做有没有好处仍存在争议。

Clinical pharmacal investigation indicates that certain drugs such as cilostazol and MY5445 could supress platelet functions through inhibiting the activity of platelet phosphodiesterase then increasing levels of cAMP, decreasing concentration of free calcium ion (Ca2+i).

临床药理表明,一些通过抑制血小板PDE活性,从而提升环核苷酸、降低胞浆游离钙离子(Ca2+i)的药物如西洛他唑、MY5445,能有效抑制血小板功能。

The platelets were labeled by FITC injected by jugular artery. Adherence of platelets to endothelial cells in pial vessel was observed by fluorescent microscope. The expression of GPⅢa protein was identified by CD61 histochemistry.

荧光显微镜下观察活体软脑膜微血管中血小板对内皮细胞的粘附,用CD61抗体经免疫组化方法观察缺血再灌注沙土鼠脑组织血管内血小板和内皮细胞上GPⅢa糖蛋白的表达。

Apheresis platelets by both preparations show excellent transfusion results in curing thrombocytopenia, but prestorage leukocyte filtration can effectively reduce the incidence rate of FNHTR.

两种方法制备的单采血小板均能有效地治疗血小板减少,但保存前过滤能更有效地减少FNHTR的发生率。

During the ESR study of the effects of oxLDL on the ESR signal intensity of hydroxyl radicals in collagen (2 μg/ml)-activated platelets, we found that incubation of human platelets with collagen produced a typical four-line hydroxyl radical signal and a long-lived g = 2.005 radical detectable by spin trapper 5,5-dimethyl-1 pyrroline N-oxide.

在研究oxLDL降低由collagen 〈2 μg/ml〉刺激血小板产生的氢氧自由基〈OH●〉的ESR讯号强度的同时,我们发现以DMPO当自由基捕捉剂,collagen除了刺激血小板产生一个四线的典型氢氧自由基之外,还产生一个长半衰期 g = 2.005的自由基。

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