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血小板

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It has been found that a single dose of TPO might be sufficient for a clinically significant response of treatment on thrombocyte recovery.

血小板生长因子(thrombopoietin, TPO)升高血小板的作用更加有效,但它可能在体内引起血栓,故尚需对其应用于体内的安全性作出进一步的评估。

Restrain thrombocyte to release 5-HT and prevent Ca channel 'of thrombocyte experimen are chosen to carry out the pharmacodynamics research. Also analysis the PK-PD model.

选择抑制血小板释放5-HT实验和阻滞血小板钙通道实验进行了药效动力学研究,并进行了药动学药效学相关性分析。

In DCXW is extract of 95% alcohol. Lisgusticum chuanxiong Hort. can restrain thrombocyte to release 5-HT,so it can reduce the vein fit caused by 5-HT. Gastrodia elata Bl. can through the "exhaust mechanism" to reduce 5-HT.

川芎是以抑制血小板释放5-HT为主,可以减少偏头痛急性期5-HT所致血管痉挛;天麻是以耗竭机制'减少血小板中的5-HT,对于偏头痛频发患者,可减少诱发因素。

Thrombocytopenia is the unit of blood platelets and decreased or lack of symptoms.

血小板减少症是指血液中血小板单位细胞数减少或缺乏的症状。

Recent studies have shown that mean platelet volume is a good indicator for BM disease in the differential diagnosis of thrombocytopenia.

近期的研究表明平均血小板体积是血小板减少症鉴别诊断中骨髓病的一个良好指标。

The events of recanalization and reocclusion were observed in two hours after giving thrombolytic agents, and following hemological items were examined: kaolin partial thrombokinase time, prothrombin time, thrombin time, fibrinogen level, platelet counts, platelet adhesion rates and aggregation rates.

观察用药后2小时内各组再通及再闭塞情况,并检查用药前和用药后1小时下列血液学指标:白陶土部分凝血活酶时间、凝血酶时间、凝血酶原时间及纤维蛋白原定量以及血小板计数、粘附率、血小板聚集率。

In this study, we investigated platelet functional changes in vitro when platelets were exposed to pharmacological concentrations of tissue-type plasminogen activator.

在本实验中,我们以溶血栓试剂组织胞浆素原活化因子(Tissue-type plasminogen activator;t-PA)体外处理血小板,并观察血小板功能的变化。

Objective:to explore the effect of different plasma triglyceride on the platelet aggregation.

目的:通过观察不同血浆甘油三酯水平患者的血小板聚集率,分析血浆甘油三酯对血小板聚集功能的影响。

Methods: We recruited 134 thrombocytopenic patients (69 men, 65 women) who were divided into two groups according to the underlying disease: group I (n = 63) included ITP patients, whereas group II (n = 71) included patients with HT due to myelosuppression secondary to chemotherapy for hematological malignancies.

收集134例血小板减少症患者(69例男性患者,65例女性患者),将其分成两组:I组为63例ITP患者,II组为71例源于血液肿瘤化疗继发的骨髓抑制性血小板减少症。

Wenxin capsule can promote endolethial cells releasing CO and synthesing 〓, enhance activity of HO, induce angiectasis through activating guanylic cyclase and adenglate cyclate of intracellar of vessel smooth muscle cell to enhance content of intracellar cGMP and AMP. 3. Wenxin capsule can inhibit releasing of platelet activiting factor 〓 which inhibit platelet aggregation and have antithrombosis function. 4. Wenxin capsule can promote activity of t-PA, reduce activity of PAI-1, strengthen fibrinolytic function, therefore inhibit fibrin disposition. 5. Wenxin capsule can inhibit synthesis of smooth muscle cellular DNA. Its function don't kill it directly but prevent transformation from period Go to peried S. 6. Wenxin capsule is an effective prescription of anti-coronary atherosclerosis atherosis. The results of image pattern analysis tastifies that area of lipid plaque in treating group reduce 54% and 58% in contrast with that in control group. The results of light, electro- microscopy show that structure of endolethial cell and smooth muscle cell in treating group is more integral than that in control group.

其作用机制之一是由于该药具有良好的调脂降脂作用,其不仅能明显降低血清LDL-c及升高HDL-c含量,且能有效阻止TC沉积于血管壁,从而保护内皮细胞结构完整;此外,温心胶囊尚具有明显的抗氧化作用,该药不仅能明显降低血浆LPO含量,且能提高SOD活性,同时其对血红素在细胞内代谢的调节作用也参与了抗氧化过程。2 温心胶囊能明显促进内皮细胞释放CO及合成〓,提高HO活性,通过激活血管平滑肌细胞内鸟苷酸环化酶及腺苷酸环化酶引起细胞内cGMP、AMP浓度增加而引起血管舒张。3 温心胶囊能明显抑制血小板激活因子〓的释放,从而抑制血小板聚集,抗血栓形成。4 温心胶囊能明显提高t-PA活性,降低PAI-1活性,增强纤溶功能,从而抑制纤维蛋白沉积。5 温心胶囊能明显抑制平滑肌细胞DNA合成,其抑制作用不是直接杀伤抑制,而是阻止细胞由Go期向S期转化。6 温心胶囊是抗冠状动脉粥样硬化的有效制剂,图象分析结果证实,该药治疗组脂斑面积比对照组缩小了54%和58%,光电镜结果显示内皮细胞及平滑肌细胞结构较为完整。

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