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血小板

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BACKGROUND: Studies demonstrated that the decrease of nitrogen monoxidum activities can lead to the cyclic guanosine monophosphate decreased, which result in platelet hyperfunction, eventually induce glomerular thrombosis.

背景:研究表明,增龄机体血小板一氧化氮合成能力下降,导致环磷鸟苷水平降低,进而使血小板功能亢进,成为血栓易感状态。

Blood lipid,blood viscosity,coagulation-time,platelet agglutination rate,lipid hyperoxide and carry-lipoprotein level were determined using Transansio automatic biochemical analyzer,automatic rinse spin rheometer and Chrono-log 400 platelet agglutinating meter respectively.

采用Transansio全自动生化分析仪、自动冲洗旋转式血液流变仪及Chrono-log400血小板聚集仪分别测定各试验组动物血脂、血粘度、凝血时间、血小板聚集率脂质过氧化物及载脂蛋白水平的作用。

However, studies of the use of antiplatelet agents within 48 hours of the ictus have examined only aspirin.

血小板治疗在急性脑梗死治疗中占有重要地位,传统抗血小板治疗主要为口服阿司匹林,但其由于存在给药途径单一、阿司匹林抵抗等问题,使其在急性脑梗死中的应用受到了一定限制。

The rezults showed that SAOH itself did not affect platelet ultrastructure and aggregation, but could inhibit platelet from changes in the shape of platelet,pseudopodium formation and granule release during aggregation induced by arachidonic acid , collagen and ADP, suggesting that SAOH are a inhibiter of platelet aggregation.

结果表明:倒卵叶五加总皂甙本身对血小板聚集和超微结构无明显影响,但可抑制AA、Collagen及ADP诱导的血小板聚集、外形改变、伪足形成和颗粒的释放。

METHODS AND RESULTS: Adherent platelets express substantial amounts of SDF-1 and recruit CD34+ cells in vitro and in vivo. A monoclonal antibody to SDF-1 or to its counterreceptor, CXCR4, inhibits stem cell adhesion on adherent platelets under high arterial shear in vitro and after carotid ligation in mice, as determined by intravital fluorescence microscopy.

方法和结果:在体和离体的粘附血小板表达大量SDF-1、募集CD34+细胞,在体荧光镜下可见,在小鼠颈动脉结扎后、离体条件下的动脉内高剪切应力时,SDF-1或其相应受体的单克隆抗体-CXCR4抑制干细胞粘附于血小板上。

Then the plateletswere returned to isotonic condition and kept for 15 minutes.

为了测定血小板对溶液渗透压变化的耐受能力,将等渗条件下新鲜血小板置于47 - 611 mOsm的系列晶体盐溶液中15 分钟,然后恢复至等渗。

No increases of positive rate of CD62p and phosphatidylserine were detected in platelets returned to isotonic condition.

不同渗透压溶液中的血小板恢复至等渗状态时血小板CD62p 和PS 阳性率没有明显增加。

N-terminal amino acid sequence determination indicated that it shares 70%, 64% and 56% identity with those of annexin Ⅱ from the African claw toad, red jungle fowl and human, respectively.

该蛋白具有以钙依赖的方式抑制专一性血小板膜糖蛋白Ⅵ受体激动剂———Stejnulxin诱导洗涤人血小板聚集的生物学功能,最大抑制率达48%。

Objective To study platelet protein kinase C′s effect on platelet activity and its role.

目的 研究急性脑梗死血小板蛋白激酶C对血小板活性的影响及其致病作用。

Group C: shorten for 1cm and fixation by unilateral lengthener. 500ul platelet-rich plasma are locally injected into distraction gap in day 17 and 27 post-operation. Group D (DBM+PRP group): fill the bone defect with 0.5cm decalcified bone matrix and 1ml platelet-rich plasma and shorten 0.5cm.

在术后第17天和术后第27天局部注射富血小板血浆500ul两次。D组:将0.5cm长的脱钙骨基质材料复合1ml富血小板血浆填入1cm的骨缺损并短缩0.5cm后外固定架固定。

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