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Methods: A recently deeloped method of sampling perilymph from the cochlear apex of guinea pigs was used in which the samples represent fluid originating from different regions along the scala tympani.

一种最近发展的从豚鼠耳顶部进行外淋巴液采样的方法被应用于该项研究,采取这种方法可以获得代表沿着鼓阶不同区域产生的液体的样本。

The pharmaceutical properties of DSP gel,such as lower critical solution temperature,DSP stability and release in vitro,were esti- mated.The pharmacokineties of DSP-loaded gel and solution were studied after an intratympanic or intravenous administration by determining the concentration of Dex in perilymph.

建立DSP和地塞米松HPLC测定方法;考察凝胶中药物的稳定性;采用扩散池方法评价其体外释放行为;与溶液剂相比较,研究鼓室注射载药原位凝胶后耳外淋巴液中药动学规律。

In 4 cases, the cavities were full of perilymph. We could find that the cavity was irregularly round-shaped, about 6.5 mm in diameter, with thin mucosa adhere to the cavity wall. In the center area, around the internal acoustic meatus fundus, there was a horseshoe- shaped cystic structure about 3 mm3, which was a combined structure of the saccule, utricle and scala media. In 1 case, there was little perilymph in the cavity, with about 1.5 mm thick soft tissue and granulation adhere to the wall. The saccule, utricle and scala media were not recognizable.

结果 对5例患者进行共同腔内耳内镜检查,见4例腔内充满液体,吸出后腔壁有扉薄黏膜附着,腔呈不规则圆形,直径平均约为6.5 mm,中央区贴近内听道底部位见马蹄形或肾形囊腔,约 3 mm3大小,为内耳球囊、椭圆囊和中阶畸形融合的结构;1例腔内淋巴液较少,共同腔壁附着软组织和肉芽,约1.5 mm厚,无法将腔壁上的软组织与中阶、球囊、椭圆囊的结构区分。

Results Five cases with common cavity underwent micro-endoscopy during cochlear implantation. In 4 cases, the cavities were full of perilymph. We could find that the cavity was irregularly round-shaped, about 6.5 mm in diameter, with thin mucosa adhere to the cavity wall. In the center area, around the internal acoustic meatus fundus, there was a horseshoe- shaped cystic structure about 3 mm3, which was a combined structure of the saccule, utricle and scala media.

结果 对5例患者进行共同腔内耳内镜检查,见4例腔内充满液体,吸出后腔壁有扉薄黏膜附着,腔呈不规则圆形,直径平均约为6.5 mm,中央区贴近内听道底部位见马蹄形或肾形囊腔,约 3 mm3大小,为内耳球囊、椭圆囊和中阶畸形融合的结构;1例腔内淋巴液较少,共同腔壁附着软组织和肉芽,约1.5 mm厚,无法将腔壁上的软组织与中阶、球囊、椭圆囊的结构区分。

Methods The viral particles of recombinant adeno-associated viral vector 2-IRES-EGFP/MnSOD(rAAV2-IRES-EGFP/MnSOD) were injected into the perilymph through the round window membrane on the 6th week.To observe the feasibility of MnSOD gene therapy for protecting the cochlear function with the methods of Westernblot, ApopTag peroxidase apoptosis detection, MnSOD activity detection and effect on hearing.

方法在半乳糖注射的第6周(注射氨基糖甙类抗生素之前2周)将rAAV2-IRES- EGFP/MnSOD病毒液经圆窗膜注入拟老化大鼠的耳外淋巴,通过免疫组化(ApopTag过氧化物酶凋亡检测)、Westernblot及MnSOD活性检测的方法观察MnSOD基因在对抗内耳氧化应激损伤中的干预性保护作用。

The distance between the line tom the intersecting point of the mandibular nerve and greater superficial petrosal nerve to the lateral lip of the internal acoustic meatus and the porus trigeminus was (8.04±0.99)mm.

颅中窝手术入路操作中,在下颌神经与岩浅大神经交点和内耳门后缘的连线的内侧磨除岩尖部骨质时,不容易损伤耳

Objective To establish a mapping protocol for infants and young children cochlear implant recipient who are not able to finish psychophysics test.

目的对不能配合完成心理物理测试的低龄小儿耳植入患者,建立适合客观响度映射调试的系列方法。

The anatomic location of cochlea is becoming more and more precise and exact from triangle to quadrilateral method.

从最初的三角法到夹角法再到四边形法,耳的解剖学定位越来越精细准确。

The results show the distributions of the velocity field and pressure field, especially for the flow in laryngeal and diffuse part. There are refluence on the tongue, but they will not affect the performance and efficiency of the HD pumps.

数值结果表明,壳内的速度场以及压力场分布相对比较均匀,在隔舌和扩散段内存在一定的回流和涡流,但并不影响泵的良好性能和高效率。

The security and reliability of the structural design of reinforced concrete spiral case is proved in this paper.

本文为有针对性地提高水电站壳结构设计的安全性与可靠性提供了依据。

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