蛋白酶

Methods: 64 cases with multiloculated pleural effusions were divided into 2 groups, the treatment group with 34 cases was treated with urokinase,injecting 100000～200000u/time and ns 10～20ml into pleural cavity;the control group with 30 cases was treated with chymotrypsin,injecting 100000～150000u/time and ns 10～20ml into pleural cavity.results: after treated with urokinase or chymotrypsin.

配合病因治疗，对64例有小房形成的胸腔积液随机分2组，治疗组34例胸腔内注射生理盐水10～20ml+尿激酶10～20万单位；对照组30例给予生理盐水10～20ml+糜蛋白酶10～15万单位。

AIM: To examine the role of matrix metalloproteinases expressed by the tartrate-resistant acid phosphatase-positive mononuclear and multinucleated cells in articular cartilage damage.

目的：观察在胶原诱导的C57BL/6小鼠类风湿性关节炎模型中，基质金属蛋白酶-2、9在耐酒石酸盐酸性磷酸酶阳性的单个核及多核细胞中的表达及其在关节软骨损伤中的作用。

In this reiew, we focus on the differentiation of mesenchymal stem cells (including those of the myoblastic, osteoblastic, chondroblastic, neural, and apidoblastic lineages) and the possible, if unexpected, biological significance of MMPs in its regulation.

在此综述中，我们着重分析间充质干细胞的分化和间充质干细胞的分化的调节过程中MMPs可能起到的生物学作用。MMP系统已经被证明涉及若干的分化效应，这显示基质金属蛋白酶调节蛋白水解酶蛋白水解级联的增殖和分化效应。

Expression analyses identified increased expression of numerous TGF-beta-related genes that regulate cell proliferation and survival and plausibly contribute to myxomatous valve disease.

他们注意到，多数效应器分子的表达增加降低了TGF-β的信号作用，包括可诱导TGF-β的H3基因、内皮素-1、组织抑制因子金属蛋白酶1、致骨形态学发生的蛋白和&调节细胞增生和存活可能还有促进粘液瘤性疾病的基因&。

To study the effect of natrahagin, a Chinese cobra venom proteinase purified from Naja naja atra Z venom on platelet aggregation,fibrinogen level and artery thrombosis.

研究从中国黑眼镜蛇毒中纯化的中国黑眼镜蛇毒蛋白酶natrahagin对血小板聚集，血浆纤维蛋白原水平和动脉血栓形成的影响。

Methods A model of active necrotic pancreatitis in rat was established.

方法复制动物模型，定量测定对照组和实验组大鼠的磷脂酶A2和弹力蛋白酶活性。

Results:(1) FSN can inhibit secondary joints swelling and multi-arthritis evidently, improve the whole condition of rats; at the same time, it can also lighten the synovial inflammation and hyperplasia of lesion joints distinctly, and prevent the joint cartilage and bone from destruction; the collective efficiency of FSN is better than TWP.(2) FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th / Ts and Thl / Th2 cells balance in peripheral blood, restrain exorbitant TNF- a ? IL-1 produced by PM O , thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF- a mRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflamination and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue,reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage.Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果：(1)FSN有明显的抗炎作用，可显著抑制AA大鼠足跖肿胀与多关节炎，改善大鼠的全身情况，同时明显减轻病变关节滑膜炎症与增生，防止关节软骨及骨质的破坏，其综合作用优于TWP；(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常，纠正外周血中T细胞亚群Th／Ts及Th1／Th2平衡紊乱，抑制大鼠PHφ过高的TNF-α、IL-1分泌，而发挥抗炎和免疫调节作用；(3)在病变关节局部，FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达，降低滑膜组织中NF-kB表达，并增加凋亡蛋白酶Caspase-3表达，从而抑制滑膜的炎症与增殖；(4)FSN还可下调滑膜组织中VEGF表达，减少血管新生，由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀；(5)FSN的上述作用皆呈现一定的量效依赖关系，高剂量组作用优于低剂量组。

FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th/Ts and Th1/Th2 cells balance in peripheral blood, restrain exorbitant TNF-α、IL-1 produced by PMφ, thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF-αmRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflammation and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue, reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage. Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果：(1)FSN有明显的抗炎作用，可显著抑制AA大鼠足跖肿胀与多关节炎，改善大鼠的全身情况，同时明显减轻病变关节滑膜炎症与增生，防止关节软骨及骨质的破坏，其综合作用优于TWP；(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常，纠正外周血中T细胞亚群Th/Ts及Th1/Th2平衡紊乱，抑制大鼠PMφ过高的TNF-α、IL-1分泌，而发挥抗炎和免疫调节作用；(3)在病变关节局部，FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达，降低滑膜组织中NF-kB表达，并增加凋亡蛋白酶Caspase-3表达，从而抑制滑膜的炎症与增殖；(4)FSN还可下调滑膜组织中VEGF表达，减少血管新生，由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀；(5)FSN的上述作用皆呈现一定的量效依赖关系，高剂量组作用优于低剂量组。

This study is to observe the effect of of Fluvastatin in adriamycin-induced nephropathic rats. Methods The 45 male rats were randomly divided into three groups:normal control group、non-treated nephropathy group、Fluvastatin-treated group.

本课题旨在通过阿霉素肾病大鼠肾小球硬化模型的建立，并应用氟伐他汀治疗，观察其对血脂、尿蛋白的影响，以及对促进ECM降解的基质金属蛋白酶-9(MMP-9)表达的影响，探讨氟伐他汀延缓肾小球硬化的作用机制。

This paper reviews the biological functions of proteasome in signal transduction and its potential roles in neurodegenerative diseases.

本文综述蛋白酶体在细胞信号转导中的生物学功能和在神经退行性疾病中的可能作用。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。