蛋白酶

Chapter 4: selectes the AHPBA as the candidates for inhibitor design for Human Immunodeficiency Virus protease. The cleavable peptides are modified according to the "distorted key" theory, and the new inhibitors are formed.

第四章：以HIV蛋白酶过渡态类似物的抑制剂为研究对象，根据&变形钥匙&理论，把可剪切肽转变成理想的竞争性抑制剂。

Objective To evaluate the value of a recombinant Clonorchis sinensis cysteine proteinase for the serological diagnosis of clonorchiasis.

目的探讨重组华支睾吸虫半胱氨酸蛋白酶在华支睾吸虫病血清学诊断上的应用价值。

Objective: To investigate the effect of scalp clustery acupuncture on matrix metalloproteinase-9 (MMP-9) in rats after cerebral infarction, and to explore the mechanism of scalp clustery acupuncture on cerebral infarction damage.

目的：通过观察头穴丛刺对脑梗死大鼠梗死灶周围基质金属蛋白酶－9(MMP-9)变化的影响，探讨头穴丛刺治疗脑梗死的作用机制。

Vernazza recommended careful monitoring of compartmental HIV RNA values and obtaining a thorough medical history, to avoid including patients whose disease has previously failed to respond to this protease inhibitor.

Vernazza医师建议，未来的单一疗法试验应该仔细检验局部HIV RNA的量，并且详细地询问医疗史，以避免纳入了过去已经使用蛋白酶抑制剂而且治疗失败的病患。

In addition, a metabolic inhibitor, actinomycin D has no effect on enzymatic activities of caspase-1/ICE-like and caspase-3/CPP-32/like proteases during Fas-mediated CD4〓T cell apoptosis. These results indicate that the appearance of caspase-1/ICE-like and caspase-3/CPP32-1ike proteases activities is a post-translational activation of these proteases. It is likely these caspases constituently express in a inactive form in the cytosol of CD4〓T lymphocytes. Once the rest SEB-responsive CD4〓T cells are restimulted, those inactive caspases such as caspase-1/ICE-like and caspase-3/CPP32-1ike proteases are sequentially cleaved to become active forms, and the apoptotic signal is transducted to downstream signaling molecules, Finally leads to CD4〓T cells apoptosis.

另外，通过代谢抑制剂放线菌素D对超抗原SEB诱导静息SEB应答〓细胞凋亡过程中Caspase成员酶活性变化的研究表明Caspase-1／ICE样，Caspase-3／CPP32样胱氨蛋白酶并非新合成的信号分子，很可能以无活性方式组成性表达于静息SEB应答〓细胞胞浆，在超抗原SEB再次刺激诱导〓细胞凋亡早期，先后顺序活化，借以传递凋亡信号到下游信号分子，诱导〓细胞凋亡。

Plant protease inhibitors as a resisting pest resource was more studied besides Bt gene, the distribution is widely, especially in the leguminosae, solanaceae, gramineae, cucurbitaceae and cruciferae plants.

植物蛋白酶抑制剂是除Bt之外又一个愈来愈研究较多的抗虫基因资源，其分布广泛，在豆科、茄科、禾本科、葫芦科及十字花科等植物中存在较多。

The total number of colony forming units of culturable bacteria and fungi were increased significantly(p.01 in transgenic sugarcane rhizosphere soil, but The total number of CFUs of culturable was not effected. No significantly higher CFUs of bacteria, fungi and actinomycetes resistant to kanamycinwere obtained in transgenic sugarcane soil.

结果表明：转基因甘蔗显著(p.05)降低了土壤脱氢酶的活性，提高了土壤的纤维素酶、蛋白酶和脲酶活性(p.01)，而对蔗糖酶和磷酸单脂酶没有影响；转基因甘蔗显著增加了根际土壤可培养的细菌和真菌数量，但对放线菌影响很小。

The two Phytophthora genomes encode large numbers of secreted proteases in contrast to the diatom and also encode the pectinases and cutinases required for hydrolyzing plant cell wall and cuticular material.

两疫霉基因组编码的大量分泌蛋白酶相反，以矽藻，也编码果胶酶和cutinases所需的水解植物细胞壁和角质层的物质。

Objective: To observe the cytotoxic effect of cisplatin with proteasome inhibitor on osteosarcoma cells.

目的：观察顺铂和蛋白酶体抑制剂对骨肉瘤细胞的杀伤作用。

Through upregulating the production of MMPs in deciduas and chorionic villi, the upregulation of the expression of EMMPRIN in syncytiotrophoblast and cytotrophoblast column of the villi in the threatened abortion can degenerate deciduas and denudates embryo.

发生先兆流产时合体滋养细胞、细胞滋养层柱所表达的EMMPRIN增强可能通过上调绒毛及蜕膜组织中基质金属蛋白酶的水平，降解细胞外基质，使绒毛剥离、蜕膜组织剥脱。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。