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Studies of the binding of metal to calmodulin and the subsequent binding of metal-calmodulin complexes to the target protein/peptide revealed that the La-content calmodulin complexes to its target exhibit similar affinity with the Ca-calmodulin complexes.However, there were substle differences in protein conformation as well as the kinetical properties between the two kinds of metal-calmodulin complexes, suggesting Ln could produce cellular effects via the Ca/calmodulin signaling systems.

稀土离子和钙调蛋白的结合以及后续和靶酶的结合,在热力学上与钙离子激活蛋白具有相同的亲合力,但在动力学性质上以及细微构象上明显不同,显示稀土离子可通过细胞钙相关信号系统产生特别的生物效应。

In addition, A new mosquitocidal toxin gene was also cloned from the natural Bacillus thuringiensis. Both the intact protein and the C-terminus truncated protein had a cytoly

在E.coli中表达完整的cyt2Ba7和其3端截短的基因,发现该蛋白的C末端15个氨基酸具有保护蛋白不被降解,降低其对宿主毒性的功能。

The mouse was carried out half nephric duct ligation to induce the renal interstitial fibrosis animal model,afterwards,to set up three groups,control group,sham operation group(intragastric administration with normal sodium according to 10ml/kg weight),treatment group...

采用小鼠单侧输尿管结扎法诱导肾间质纤维化的动物模型,用盐酸青藤碱治疗,并设对照组、假手术组(小鼠每日按10m l/kg体重用生理盐水灌胃,直至治疗结束)、治疗组(选用正清风痛宁缓释片按每日30mg/kg体重给小鼠灌胃,连续3周,),检测血尿素氮、血肌酐、血清层粘连蛋白、纤维连接蛋白的含量,免疫组化法测肾脏组织转化因子β1(TNF-β1)的表达并进行肾脏病理学的观察。

To 26. 23, P <0. 01.CONCLUSION: Chlamys farreri is capable of increasing Bcl-2 protein and decreasing Bax protein in cerebral penumbra to brake the initiation of neuron apoptosis after ischemia-reperfusion and preserve neuronic function in penumbra.

扇贝多肽能够上调脑缺血半影区内抑制神经细胞凋亡的Bcl-2蛋白水平,同时降低半影区内诱导神经细胞凋亡的Bax蛋白的表达,从而在阻止脑缺血再灌注后细胞凋亡启动中起制动作用,保护脑缺血后半影区内神经元的功能。

Ochotona curzoniae and Microtus oeconomus might be de-sensitive or have high endurance to hypoxia;hypoxia had smaller effects on their Epo expressions in both the kidney and the prefrontal cortex.

高原鼠兔和根田鼠大脑前额叶皮层Epo的蛋白表达在10.8%O_2和8.0%O_2的常压低氧条件下没有变化;10.8%O_2和8.0%O_2的常压低氧显著促进了小鼠大脑前额叶皮层Epo蛋白的表达。

PDJ also could induce expression of PRP, and this trend was significant when the tobacco seedlings were infected by Phytophthora parasitica Var nicotianae. The results suggested that the increased activities of these enzymes and the expression of PRP is most likely to be associated with the development of induced resistance in tobacco seedlings.

PDJ处理同样诱导了烟草体内某些病程相关蛋白的表达,并且在黑胫病菌侵染后表达增强,这些结果表明PDJ处理后烟草酶活性的变化和病程相关蛋白的表达可能与其诱发烟草幼苗系统获得抗性的表现有关。

After inoculation with Phytophthora parasitica Var nicotianae, the activities of these enzymes in PDJ-treated tobacco were higher tha...

PDJ处理同样诱导了烟草体内某些病程相关蛋白的表达,并且在黑胫病菌侵染后表达增强,这些结果表明PDJ处理后烟草酶活性的变化和病程相关蛋白的表达可能与其诱发烟草幼苗系统获得抗性的表现有关。

There are still modifications being done in terms of whether you can recirculate the albumin that is being cleansed back to the patient because the binding capacity of albumin may be affected in liver disease and may not be corrected by the Mars device.

由于白蛋白的结合能力可能受肝脏疾病的影响,MARS治疗设备无法纠正这种功能,所以存在能否将净化后的白蛋白回输患者体内这些方面的问题,这些技术仍需被调整。

The bcl-2/bax of Safflor group treated before ICH 24 hours ahead,after ICH 0 hour were lower than that of Safflor group treated after ICH 6,12 or 24 hours. When the treated group were injected Safflor after ICH 6,12,24 hours,The number of caspase-3 positive cell around

在不同时间给予红花注射液治疗脑出血大鼠,均能不同程度地促进脑出血大鼠神经功能的恢复,其中术后6h给药组治疗效果最好,其可能通过促进Bcl-2蛋白的表达,抑制Bax和Caspase-3蛋白的表达,从而抑制血肿周围的细胞凋亡。

When the treated group were injected Safflor after ICH 6,12,24 hours,The number of caspase-3 positive cell around hematoma was gradually increased and the number of bcl-2/bax positive cell was gradually degraded and the number of TUNEL positive cell of Safflor group treated after ICH 6 hours were less than that of Safflor group treated after ICH 24 hours.

在不同时间给予红花注射液治疗脑出血大鼠,均能不同程度地促进脑出血大鼠神经功能的恢复,其中术后6h给药组治疗效果最好,其可能通过促进Bcl-2蛋白的表达,抑制Bax和Caspase-3蛋白的表达,从而抑制血肿周围的细胞凋亡。

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