蛋白休克

One hand mechanical obstruct led to the increase of veinous resistance and the obstacle of microcirculation, the other hand the adhesive PMN was activated in excess, the white blood cells released a lot of enzymes, in which PMN-elastase can decompose the components of cell and many albumens, inclusive of immunoglobulin、alexin and fibrication. These components induced the injury of the pancreatic capillary vessels and cell and lysosome enzy made the tissue protein hydrolyze and produced unsaturated fatty acids, which destroyed the structure and function of cellar membrane. The inflammatory cellar factors activate other immunocytes to produce the injury and necrosis of tissue, which aggravated the pathological injury and led to shock、pyaemia and MODS. So ICAM-1 and LFA-1 played an important role in SAP. Frossard found that the expression of ICAM-1 in the rat model, especially in serum、pancreas and lung. All these showed ICAM-1 is an important factor in AP and concomitant lung injury.

胰腺小叶组织局部血管EC首先被激活，ICAM-1表达升高，与被激活的PMN表面表达的LFA-1相结合，"PMN-EC"相互作用加剧，一方面机械性阻塞毛细血管导致静脉阻力增加、微循环障碍；另一方面粘附的PMN过度吞噬或激活，当白细胞吞噬的颗粒不能被封闭隔离，连同细胞内的酶被释放出来，其中的PMN-elastase能够降解细胞基质中各种成分，水解多种蛋白，加重胰腺的毛细血管内皮细胞和腺泡的损伤；释放的溶酶体酶使组织蛋白水解，产生的不饱和脂肪酸引发脂质过氧化方应，破坏细胞膜的结构和功能；释放的炎性细胞因子，激发其他的免疫细胞的功能，导致进一步的组织损伤和坏死，加重SAP的病理损伤，最终导致休克、脓毒血症及多器官功能障碍等严重后果。

Further bioinformatical analysis indicated that the three Y-box genes of lamprey, i.e., Lyb1, Lyb2, and Lyb3, encoded 331, 181, and 171 amino acids, respectively. The three amino acid sequences were homologically aligned with those from Ciona intestinalis, Danio rerio, Oryzias latipes, Takifugu rubripes, and Mus musculus by DNAMAN software.

采用DNAMAN软件，将七鳃鳗的3个Y-box蛋白氨基酸序列与海鞘、斑马鱼、清鳉、河豚鱼和小鼠Y-box蛋白进行同源性分析，结果显示他们共有一个保守的冷休克结构域，其中包含两个RNA结合基序RNP-1和RNP-2，表明获得的Lyb基因属于Y-box 基因家族成员。

Objective To study the effects and significance of Bax protein and heat shock protein 70 (HSP70) in prevention of insulitis and diabetes by complete Freund's adjuvant in female NOD mice.

目的 研究Bax蛋白和热休克蛋白70在完全弗氏佐剂预防NOD鼠胰岛炎和糖尿病中作用及意义。

Objective To establish an effective method for purificating recombinant HspA-UreB fusion protein of Helicobacter pylori from inclusion body.

目的：建立一种有效的纯化幽门螺杆菌热休克蛋白A亚单位-尿素酶B亚单位融合蛋白包涵体的方法。

Objective To study the effects of heat-shock protein fusion protein on the differentiation and maturation of human monocyte derived dendritic cells.

目的：研究热休克蛋白融合蛋白对人树突状细胞分化成熟的刺激作用。

Results Wenshen Kechuan Tablets could significantly prolong the cough latent period and cough times within 3 min and increase phenol red secretion from trachea in cough model induced by ammonia water. Wenshen Kechuan Tablets could significantly prolong the asthma latent period and relieve spasm in guinea pigs with histamine-acetylcholine-induced asthma, prolong spasm latent period and reduce shock attack and lung overfall volume in guinea pigs with ovalbumin-induced asthma.

结果 温肾咳喘片可显著延长氨水致咳小鼠的引咳潜伏期、减少3 min内的咳嗽次数，增加小鼠气管段酚红排泌量，明显延长组胺－乙酰胆碱致敏豚鼠的引喘潜伏期、减少抽搐动物数，延长卵白蛋白致喘豚鼠抽搐潜伏期和减少跌倒休克豚鼠数，减少卵白蛋白致敏麻醉大鼠的肺溢流量。

Lavoie JN, Hickey E, Weber LA, et al. Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27.

热休克蛋白（heat shock protein， HSP）又称应激蛋白（stress protein， SP），是机体细胞在应激原诱导下，高效表达的一组蛋白质。

Heat shock protein 70 (HSP70) is a sort of unspecific protein which can be induced by acupuncture and moxibustion.

热休克蛋白 70 (HSP70)是一种非特异性细胞保护蛋白，针灸可诱导其产生。

Objective To study the expression of Glial fibrillary acidic protein and Heat shock protein 70 after different time of cerebral ischemia, and they can be used for estimating the time of cerebral ischemia in forensic medicine aspect.

目的探讨大鼠脑组织缺血后不同时间胶质原纤维酸性蛋白(Glial fibrillary acidic protein，GFAP)和热休克蛋白70(Heat shock protein 70，HSP70)的表达，旨为法医实践中推断脑组织缺血时间提供科学的参考依据。

Using Western blot method to measure HSP of hypothalamus in febrile and hypothermal rats.

取高、低体温大鼠下丘脑组织，应用蛋白印迹法测定热休克蛋白含量。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失