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The 20S catalytic core of the 26S proteasome has the shape of a barrel made of four rings which are composed of seven differentαsubunitsα_1-α_7 at two outer rings and seven differentβsubunitsβ_1-β_7 at two inner rings at which the catalytic sites locate. Three of theβsubunits contain proteolyses sites, which are sequestered in the hollow interior of the 20S particle. Substrates enter the 20S through a narrow channel formed by theβsubunits, whose N-termini, depending on their conformation, can either obstruct or allow substrate entry and thus function as a gate. This entry channel is narrow and only permits passage of unfolded, linearized polypeptides.

哺乳动物26S蛋白酶体是由一个20S催化颗粒(catalytic particle,CP)和两个19S调节颗粒(regulatory particle,RP)组成的ATP(adenosine-triphosphate,ATP)依赖性蛋白水解酶复合体。20S CP是26S蛋白酶体的催化核心,它是由4个圆环堆叠形成的桶状复合物,其中两侧外环每个环是由α_1-α_7亚基组成,两个内环每个环是由β_1-β_7亚基组成,4个环的中央形成一个狭窄的内腔。2个β内环形成了20S CP的催化中心空腔,其内壁为催化活性位点所在地;外侧α环中心的孔道是底物到达催化中心空腔的通道,一般被α亚基上的N末端所封闭,阻止胞内非目的靶蛋白进入20S CP内被降解破坏。

From 140 candidate proteins identified in the initial screen, they focused on those with qualities logically inoled in differing leels of irulence, such as high ariability of the sequence and the ability to be secreted from the organism to enter the host.

在初次筛选中选出的140个候选蛋白中,他们集中研究具有产生不同程度毒性特质的蛋白,如高度易变性以及隐匿性。

Therefore, may improve the feed quality of the bean cake effectively using the aerthworm protease to soy protein's decomposition.

因此,利用蚯蚓蛋白水解酶对大豆蛋白的分解作用可以有效地改善豆粕饲料的品质。

Numerous artificial flavorings, particularly MSG ( A compound that hurts your brain cells ) are added to soy protein isolate and textured vegetable protein products to mask their strong "beany" taste and to impart the flavor of meat.

Mercola on Soy "众多的人工调味料,特别是味精(一种复合伤害你的脑细胞)被添加到大豆分离蛋白和植物蛋白的质感的产品来掩饰其强烈的"豆的品味和传授风味的肉类。

More recent evidence to bear the weight of the benefits of a restrained carbohydrate way of life for heart risk factors such as low HDL and small LDL lipoprotein standard.

最近证据承受重量的好处克制碳水化合物生活方式心脏风险小等因素,低密度脂蛋白水平低的高密度脂蛋白

In this study, collagen films were crosslinked by two commonly used crossliking agents, namely glutaraldehyde and epoxy. The mass transfer characteristics of the crosslinked collagen films were determined using theophylline and benzocaine.

在本实验中,使用两种常见的交联剂-戊二醛(glutaraldehyde,简称GTA)以及环氧树脂来改质胶原蛋白薄膜,并选用两种药物:theophylline及benzocaine,来探讨药物在经过交联的胶原蛋白薄膜中质传系数的改变。

Methods Cadmium-specific promoter PcadA was obtained by PCR from pPcadA and was ligated to E.coli-B.subtilis shuttle vector pNGFP with gfp being reporter gene ,after which the recombinant plasmid was transformed into 1A751 strain to form the bio-engineered bacteria.

采用聚合酶链式反应从质粒pPcadA上扩增得到重金属镉离子特异性启动子PcadA,以绿色荧光蛋白基因为报告基因,以大肠杆菌-枯草杆菌穿梭载体pNGFP构建了绿色荧光蛋白镉离子诱导表达载体。

And B23 is the mark protein of Granular component region in nucleus,and plays a vital role in ribosome biogenesis.

而B23是核仁颗粒组分区的标志蛋白,跟更重要的是,它是一个在核糖体发生中具有重要作用的蛋白

With the development of proteomic and genomics, the technology of molecular bionics has become the topic of biologic study in world.

随着基因组学和蛋白组学的研究进展,模拟活性蛋白合成仿生分子的研究越来越引起人们的关注。

There was no difference of hordeins spectrum biotype between genetically homogeneous accessions propagated in different years.

结果表明,有5份种质是具有一种醇溶蛋白语带带型的同质性种质,15份是具有2~6种醇溶蛋白谱带带型的异质性种质;同质性品种不同繁殖年份之间的谱带带型没有变化,而在15份异质性种质中有4份的带型数量及频率则发生了变化。

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I didn't watch TV last night, because it .

昨晚我没有看电视,因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来,在北京的很多小区里,电梯液晶电视被撤了下来。

I'm running my simile to an extreme.

我比喻得过头了。