蛋白

In rat hippocampal slices, TBS induced phosphorylation of p21-activated kinase and its downstream effecter cofilin, signaling proteins that enable actin filament growth.

在鼠海马切片中，短暂快速脉冲刺激导致蛋白激酶21的磷酸化，在它的下游区产生了cofilin ，一种能使肌动蛋白丝生长的信号蛋白。

It was found from the structure-electrochemical studies of myoglobin that (1) electroreduction induces the T→R configuration transition with peak shift in CD spectra and without umbrella conversed effect, which proved that umbrella conversed effect is mainly the cooperation of four subunits in hemoglobin;(2) the mechanism of EC with adsorption of reduction product and parameters have also been obtained.

肌红蛋白的结构-电化学研究中发现：（1）电化学还原诱导了肌红蛋白的T→R构型转化，伴随着CD谱的峰位移，但没有象血红蛋白那样明显伞翻转效应，表明伞翻转效应是多个亚基共同作用的结果；（2）获得肌红蛋白电化学还原的EC机理，并伴随产物吸附的自阻碍过程及其参数。

These findings were consistent with the results of E20 cerebral cortex. iNOS was detected in E14 brain and There were no evidence changes of expression of iNOS in the encephalocoele group compared with the control group.

在Western blot分析中，发现与对照组比较，E14脑膨出组胎鼠大脑皮质中nNOS蛋白表达明显减少，eNOS蛋白表达水平明显增加，与E20结果相一致；在E14胎鼠大脑皮质中检测到iNOS蛋白微量表达，但脑膨出组与对照组比较无明显差异，E20胎鼠大脑皮质中未检测到iNOS表达。

Department of Pathology, Medical College of Shantou University, Shantou,515041,Guangdong,ChinaAbstract BACKGROUND ＆ AIM: To investigate the expression of early growth response gene-1 (Egr-1 gene) and PTEN in esophageal epitheliosis and carcinogenesis, and the relation with the development of esophageal carcinoma.

背景与目的：研究食管粘膜上皮癌变过程早期生长反应基因(Early growth response gene-1， Egr-1 gene)和与张力蛋白及辅助蛋白同源、第10号染色体丢失的磷酸酶基因(phosphatase and tensin homology deleted on chromosome ten，PTEN)蛋白的表达，并探讨其与食管癌发生的关系。

Equimolar BSA and hemin were combined in vitro to form hemalbumin based on the vivid property of bovine serum albumin, of which the peroxidase activity was examined .

鉴于血清白蛋白分子的活泼性，在体外将牛血清白蛋白(bovine serum albumin，BSA)与氯化血红素以相同摩尔量结合制成血红白蛋白，测定了其过氧化物酶活性。

There are experimental results as follows:(1) Eriophorum comosum Nees shows strong cold resistance in plasmalemma permeability research. The lethal temperature of Eriophorum comosum Nees is the lowest LT_(50 in comparison with another two plants and is lower than -11.5℃ in August 2005 and December 2005; Soluble protein content of each plant is rising before or after cold hardiness. By SDS-PAGE, Protein band is analysed. Band quantity of Eriophorum comosum Nees is the most and its band color is darkest.(2) Soluble sugar content of three plants after cold hardiness are higher than before cold hardiness, moreover soluble sugar content after cold hardiness shows a decline and there is a narrow range in Eriophorum comosum Nees; Free Proline accumulation is changed by cold stress, and cold resistance is relative to free Proline accumulation; chlorophyll content of both three plants, including chlorophyll a, chlorophyll b and chlorophyll a/b, show a decline tendency along with the descent of temperature. Cynodon dactylon is highly sensitive to cold stress.(3) The soil POD and urease activities' absolute value of Erioophorum comosum Nees and Pogonatherum panideumHack were more than that of Cynodon dactylon before or after low temperature stress, especially POD activities.

实验结果表明：(1)在膜透性的研究中，丛毛羊胡子草抗寒性最强，采用电导率法测得半致死温度LT_(50最低，丛毛羊胡子草抗寒锻炼前后半致死温度LT_(50均小于-11.5℃；在可溶性蛋白含量研究中，抗寒锻炼前后三种植物的可溶性蛋白含量均增加，同时采用SDS-PAGE法，通过对蛋白条带分析，以丛毛羊胡子草条带数最多且着色深；(2)在可溶性糖的研究中，三种植物经抗寒锻炼后叶片可溶性糖含量都比抗寒锻炼前高，且经过抗寒锻炼后三种植物可溶性糖均呈下降趋势，丛毛羊胡子草可溶性糖含量下降较小；从游离脯氨酸含量可知，低温的胁迫影响了植物叶片游离脯氨酸的含量变化，植物的抗寒性与游离脯氨酸有关；低温胁迫下三种植物叶绿素含量随着温度的下降，叶绿素含量、叶绿素a、叶绿素b和叶绿素a／b均呈下降趋势，狗牙根对低温胁迫最为敏感；(3)低温锻炼前后，丛毛羊胡子草和金发草的土壤过氧化物酶与脲酶活性的绝对值均大于狗牙根的，特别是过氧化物酶，说明丛毛羊胡子草和金发草的酶活性大于狗牙根的。

The data shoewed that esculetin, resveratrol enhanced LPL expression up to about 1.2 ~3.5 fold compared with the control group. In addition to fibrates, however, no effect on LPL expression by curcumin was observed. We concluded that esculetin and resveratrol enhanced LPL expression on CHO-K1 cell. We hope that we can apply these drugs to mutant form LPL, furthermore apply theses drugs into clinical treatment.

利用药物处理有转染带有完整人类脂蛋白解脂酶启动子和脂蛋白解脂酶cDNA 序列(-1715 ~+1643)质体的CHO-K1细胞，从细胞培养液以及细胞溶解物中发现，除了curcumin之外所有药物都可以使得细胞培养液以及细胞溶解液内的脂蛋白解脂酶活性有1.2至3.5倍的上升，由此结果可知除了curcumin外，esculetin和白藜芦醇以及其他fibrate药物可降低三酸甘油脂血症。

Simultaneously, the total extractible myoglobin decreased and the proportion of metmyoglobin increased significantly when the pressure above 400MPa. Beef discoloration after pressure processing may result from oxidation of ferrous myoglobin to ferric metmyoglobin, globin denaturation and structural changes. At 40℃, the changes of beef color was similar to that of room temperature's. When the temperature rise to 60℃, most of muscle proteins denatured, a small quantity of native myoglobin could not affect the color of beef significantly. Therefore, protein denaturation was attributed to the main cause of discoloration in beef muscle after pressurization at 60℃.

压力处理导致色泽变化的直接原因可能是由于二价铁的肌红蛋白氧化成三价铁的高铁肌红蛋白、球蛋白的变性及结构的变化所致。40℃时的压力处理，色泽的变化规律与室温下相似，只是色泽变化的程度更为剧烈，蛋白质变性在色泽变化中起到的作用逐渐加强。60℃下的压力处理，绝大部分蛋白质发生变性，少量未变性的肌红蛋白对色泽不会产生明显的影响，此温度的压力处理，蛋白质变性是造成肌肉失去红色的主要原因。

The propagation mechanism of the prion diseases is widely accepted that PrPsc transforms PrPc into the pathological form and more and more PrPsc will gradually be produced and forms larger fibrillar aggregates.

羊瘙痒症是最早发现的朊蛋白病，而疯牛病在英国的流行以及新近发现的新变种的人类雅各布氏病引起研究者们对朊蛋白疾病及其致病蛋白的更大关注。

It is inferred that HIRA proteins of gibel carp and coloreded crucian carp raise the possibility of a conserved function in the regulation histone gene expression because CagHIRA and CaHIRA also have 7 conserved WD repeats in their amino-terminus which found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing.

CagHIRA和CaHIRA的N端同样具有7个WD结构域，由于含有WD结构域的蛋白具有调节信号传递和mRNA前体加工的功能，可以推测银鲫和彩鲫HIRA蛋白可能同样具有调节组蛋白基因表达的作用。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。