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Observe the effect of Fuling Gancao Decoction on gastric liquid emptying and content of nitric oxide and acetylcholine esteras in the gastric fundus,antrum and duodenal tissu of functional dyspepsia rats and investigate the mechanism.1 Reference reviewThe reference review discussed the source of disease name of TCM for FD,etiology and pathogenesis of TCM,selection of therapeutic methods by different stages or according to the differential syndrome diagnosis,advance on the clinical and experimental research as well as the problems lying in the research of TCM and corresponding strategies.We also have summarized the recent research progresses on the FD.In the meanwhile,we further exploited the pathologic characteristics,diagnosis and treatment of FD;summarized etiology and pathogenesis of TCM for FD and application of Classical Prescriptions in clinical and experimental study;Collected and arranged the Literatures and summarized the recent research progresses of Fuling Gancao Decoction;Finally, collected and arranged the literatures of proved cases and clinical experiences of Fuling Gancao Decoction.2 Theoretical studyThe Theoretical study first discussed the source of TCM for stomach deficiency and congestion of fluid-retention in syndromes of FD;Secondly, summarized the indications of Fuling Gancao Decoction,that is:①epigastric throb,②cold hands and feet in syncope,③hydroadipsia,④gastric blockade,⑤gastric splashing sound,⑥no desire for drinks,⑦light white tongue,thin-white and smooth fur,⑧deep and wiry pulse are the indications of Fuling Gancao Decoction;Subsequently,analyzed the composition of Fuling Gancao Decoction,considered that ginger is the main drug which treating congestion of fluid-retention in Middle-Jiao by Zhang Zhongjing.3 Experimental study3.1 Experiment oneObjective:To establish the animal model of FD with delayed gastric liquid emptying and evaluat it.

同时观察茯苓甘草汤对FD大鼠胃液体排空及胃底、胃窦及十二指肠中乙酰胆碱酯酶、一氧化氮含量的影响,探讨茯苓甘草汤的作用机制。1文献综述参照古、今中医有关文献对FD的中医病名、病因病机、辨证论治方法、临床及实验研究进展进行了探讨,并对现代医学在FD研究中所取得的(来源:A0bBC论文网www.abclunwen.com)进展进行了总结,进一步明确了FD的发病机制、诊断和治疗的研究进展;总结了中医对FD的病因及发病机制、中医诊断及经方治疗FD临床及实验研究进展;并搜集和整理已发表的有关茯苓甘草汤研究报道,阐述了茯苓甘草汤的现代研究进展;最后搜集和整理了近现代著名医家应用茯苓甘草汤的经验及验案。2理论研究理论研究部分首先对功能性消化不良胃饮停证的认识进行了理论溯源;其次对茯苓甘草汤的适宜证象进行总结,认为:①心下悸,②四肢不温,③口不渴,④胃中痞满,⑤胃中振水音,⑥不欲饮水,⑦舌淡白,苔薄白而滑,⑧脉沉弦是茯苓甘草汤的主证;随后对茯苓甘草汤方药组成解析,认为生姜是仲景治疗中焦饮停的一味主药。3实验研究3.1实验一目的:探讨建立功能性消化不良胃饮停证的动物模型方法并对其进行评价。

Patients measure up hyperpietic diagnosetic standard according to syndromes differ types were divided into the following four types as the GanhuoKangsheng Type,the YinXuyangKang Type,the YinYangLiangXu Type,and the TanShiYongSheng Type,observe the blood pressure、the stage of hypertensive diseases、the course of diseases and the changes in fodus,stat and analyse these datum, ascertain the relationship between hypertensive retinopathy as well as the blood pressure、the course of hypertension and the TCM syndrome types,then discuss the influence that age and lipid act on retinopathy.

对符合高血压诊断标准的132例原发性高血压病患者进行中医辨证分型为肝火亢盛型、阴阳亢型、阴阳两型、痰湿壅盛型,观察血压水平、分级、病程、视网膜病变,对调查资料进行统计分析,探讨高血压性眼底血管病变、血压水平、病程与中医证型之间的相关性,并探讨年龄、血脂因素对眼底血管改变的影响。

Objective To investigate the effects of nano traditional Chinese medicine on experimental hypofunction of spleen ulcerative colitis rat model.

目的 研究纳米中药对鼠急性脾型溃疡性结肠炎模型的影响方法利用苦寒泻下中药番泻叶,灌服大鼠,使其产生脾症状,再用冰乙酸化学刺激法复制溃疡性结肠炎病理模型。

Methods: Models of leucocytopenia induced by irradiation were prepared by 60Co -ray.

采用~(60)Co照射小鼠,造成小鼠白细胞减少模型,即产生小鼠血证。评价SMI对于~(60)co所致的小鼠血证的治疗作用。

SMI had protection and therapeutic effects on leucocytopenia of mice induced by irradiation.

试验还显示,照射后四天SMI大、中剂量组小鼠骨髓有核细胞数与正常对照组无显著性差异,说明其骨髓造血功能比较活跃,提示SMI对放射性损伤所致小鼠血证有一定的保护和治疗作用,对于小鼠白细胞减少有较好的治疗效果。结论:SMI对小鼠放射性损伤所致血证有一定的保护和治疗作用。

Lienal empty is wet as a result tired model the F-ERG of AMD is changed relatively liver kidney deficit AMD is remarkable, oozy model the F-ERG change of AMD is more atrophic model lienal empty of AMD remarkable; is wet strand model those who reach P-VEP of liver kidney deficit patient to all have different rate is unusual, but unusual rate and card of doctor of traditional Chinese medicine have nothing to do; is treated through card of differentiate of doctor of traditional Chinese medicine, of patient F-ERG bright get used to amplitude to rise somewhat, the amplitude of P-VEP rises somewhat, conceal is shortened from time to tome.

结果脾湿困型AMD的F-ERG改变较肝肾亏损型AMD显著,渗出型AMD的F-ERG改变较萎缩型AMD显著;脾湿困型及肝肾亏损型患者P-VEP均有不同程度的异常,但异常率和中医证型无关;经过中医辨证治疗,患者F-ERG的明适应振幅有所提高,P-VEP的振幅有所提高,潜伏时有所缩短。

Objective: To observe the clinical effect of Compound Polyporus Umbellatus Decoction in treating the syndrome of Yin-deficiency and water-heat combined in the chronic glomerulonephritis Patients.

运用复方猪苓汤与单纯猪苓汤对慢性肾炎阴水热互结证患者疗效优劣之比较,探索治疗慢性肾炎阴水热互结证更为有效的治法及方药。

Pyretic toxicity, humid heat and stagnant blood become pathology cause to worsen the pathogenetic condition again. The TCM treatment in IgA nephropathy gain good curative effect.

是IgA肾病发病的根本原因,在疾病过程中,往往因致实,产生以热毒、湿热、瘀血为主的标实之证,而热毒、湿热、瘀血又成为使病情恶化加重的病理因素。

Results ①Five days after abdominal application of Xiaoji power(0.1 g per mouce),the medicine showed a very significant effect in enhancing gastrointestinal propulsive function.② Xiaoji powder not only had relaxing effect on the normal smooth muscle in vitro,but also had a strong spasmolytic effect on acetylcholine,green bariuminduced spasm of intestinal smooth muscle.The experiment was based on 10 μg atropine sulfate as a positive control to carry out control experiments.It showed the graphics of atropine sulfate in spasmolytic role.③Xiaoji powder navel paste therapy played a positive role in adjusting the gastrointestinal electric disorder caused by deficiency of spleen Qi,and could restore it to its normal state.

结果 (1)以0.1 g/只消积散给予小鼠腹部用药5 d,即显示非常显著的增强胃肠推进功能作用;(2)消积散不仅对正常离体平滑肌有舒张作用,同时对由于乙酰胆碱、氯化钡引起的肠平滑肌痉挛也有强的解痉作用,该实验是以硫酸阿托品10 μg作为阳性对照药进行对照实验,显示了硫酸阿托品的解痉作用图形;(3)消积散敷脐对脾引起的胃肠电紊乱有明显的调节作用,使脾大鼠的胃肠电基本恢复到正常状态。

Methods:(1) The two-sided ovary of female animal and the two-sided testicle of male animal were excised. After the XLGBC to treat 28 days, the estradiol and the teststerone of serum were checked;(2) With intramuscular injection the Hydrocortisone,the Yangxu animals was made. After the XLGBC to treat 10 days, the testicle coefficient,the spermathecal gland coefficient and the ovary coefficient were observed;(3) With ig the Thyroid tablets and the Reserpine, the Yinxu animal was made. After the XLGBC to treat 10 days, the testicle coefficient,the spermathecal gland coefficient and the ovary coefficient were observed.

(1)雌性动物摘除双侧卵巢,雄性动物摘除双侧睾丸,复制成去势动物模型后予仙灵骨葆胶囊治疗28天,检测血清雌二醇和血清睾酮;(2)肌注氢化可的松,复制成阳动物模型后予仙灵骨葆胶囊治疗10天,观测并计算动物的睾丸系数、精囊腺系数和卵巢系数;(3)灌胃甲状腺片和利血平,复制成阴动物模型后予仙灵骨葆胶囊治疗10天,观测并计算动物的睾丸系数、精囊腺系数和卵巢系数。

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