藜芦碱

Cevadine was isolated from Eranthis hyemalis and its effects on normal cats blood pressure, hypertension rats and their tolerance to cevadine were determined by using direct carotis and indirect arteria caudilis manometric methods.

从藜芦中提取分离出藜芦碱，采用颈动脉直接测压法和尾动脉间接测压法，测定了其对正常猫血压、高血压大鼠的影响及其快速耐受性。

In addition, veratridine significantly attenuated the effects of lidocaine and TTX.

另外，无定形藜芦碱明显减弱利多卡因和TTX的作用。

We also used tetrodotoxin and veratridine to elucidate the possible role of voltage-sensitive Na channel.

我们也用了TTX和无定形藜芦碱来阐明电压敏感性钠通道的可能作用。

The results suggest that veratridine and aconitine induce different firing patterns in injured DRG neurons, which may relate to their inhibitory effects on different binding sites of the sodium channel.

实验结果表明，藜芦碱和乌头碱在受损的背根节神经元可以引发不同的放电模式，这可能与它们结合于钠通道上不同位点的抑制作用有关。

OBJECTIVE: To observe the characteristics of epileptiform activities of rat hippocampal CA1 pyramidal neurons induced by low-dosage veratridine and investigate its possible ion mechanism.

目的：观察小剂量藜芦碱诱发大鼠脑海马CA1区锥体神经元产生癫痫样活动的特征，探讨其可能的离子机制。

A specific bursting, parabolic bursting induced by veratridine, has been observed in rat injured sciatic nerve.

在大鼠受损坐骨神经上加入 5 μmol L藜芦碱溶液，观察到了抛物线簇放电的现象。

The firing patterns induced by veratridine and aconitine, inhibitors of inactivation gate of sodium channel operating on different binding sites, were compared.

藜芦碱和乌头碱是钠通道失活门的抑制剂，但二者作用于不同的位点，前者结合于D2-S6，后者结合于D3-S6。我们比较了这两种试剂引发的放电模式。

The slow sodium influx educed by veratridine and the calcium-dependent potassium outflux are regarded as the two slow variables, which are responsible for the parabolic bursting.

结合实验模型，从离子通道活动的角度揭示了抛物线簇放电发生的生物物理机制。由藜芦碱诱发的慢变钠内流和钙依赖钾外流被认为是引发实验所观察到的抛物线簇放电的两个慢变量。

In the same neuron, veratridine (1.5～5.0 μmol/L) caused slow wave oscillations of interspike intervals, while aconitine (10～200 μmol/L) caused tonic firing.

结果发现，在同一神经元，藜芦碱(1.5～5.0 μmol/L)可以引起放电峰峰间期的慢波振荡，即峰峰间期由大逐渐减小，然后又逐渐增大，形成重复的振荡波形，每个振荡持续约数十秒至数分钟；而乌头碱(10～200 μmol/L)则引起强直性放电，即峰峰间期逐渐减小，然后维持在一个稳定的水平。

Cevadine was isolated from Eranthis hyemalis and its effects on normal cats blood pressure, hypertension rats and their tolerance to cevadine were determined by using direct carotis and indirect arteria caudilis manometric methods.

目的 开发新型降压药奠定理论基础方法从藜芦中提取分离出藜芦碱，采用颈动脉直接测压法和尾动脉间接测压法，测定了其对正常猫血压、高血压鼠的影响及其快速耐受性。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。