藜芦定

A yellowish-white, amorphous powdered alkaloid, C36H51NO11, obtained from sabadilla seeds and from the rhizome of hellebore.

藜芦定一种略带黄色的非晶体的粉末状生物碱，c36h51no葎11，从沙巴草籽和藜芦根中提取

A yellowish - white,amorphous powdered alkaloid ,C36H51NO11,obtained from sabadilla seeds and from the rhizome of hellebore.

藜芦定一种略带黄色的非晶体的粉末状生物碱，C36H51NO？11，从沙巴草籽和藜芦根中提取

In addition, veratridine significantly attenuated the effects of lidocaine and TTX.

另外，无定形藜芦碱明显减弱利多卡因和TTX的作用。

We also used tetrodotoxin and veratridine to elucidate the possible role of voltage-sensitive Na channel.

我们也用了TTX和无定形藜芦碱来阐明电压敏感性钠通道的可能作用。

RESULTS: As predicted, intrathecal infusion of veratridine increased MAC.

结果：与预期的一样，蛛网膜下腔注射藜芦定会增加 MAC 值。

METHODS: We measured the change in isoflurane MAC caused by intrathecal infusion of various concentrations of veratridine into the lumbothoracic subarachnoid space of rats.

我们测量大鼠在不同浓度藜芦定注入蛛网膜下腔所引起的异氟烷 MAC 值的改变并与侧脑室灌注所得的结果进行比较。

We hypothesized that the intrathecal administration of veratridine, a drug that enhances the activity or effect of sodium channels, should increase MAC.

我们假定蛛网膜下腔注射藜芦定能增加钠通道的活性和效应则会增加 MAC 值。

As noted above,membrane-stabilizers unexpectedly improved the heart function andprevented ER stress both in vivo and in cultured cells.We know that the membranestability depends on the sodium homeostasis in fact.To investigate whether ER stress isassociated with sodium channel action,which determins the membrane stability,wepretreated H9c2(2-1) cells with veratridine,a sodium channel activator.

上面的研究发现膜稳定剂在体内体外均抑制了内质网应激，并改善了心脏功能，而膜稳定作用实际上是维持细胞钠离子稳态的结果，为了研究内质网应激反应与钠离子活动的关系，我们用一种钠通道激活剂藜芦定刺激H9c2(2-1)细胞，30分钟时GRP78表达增加；24小时时PERK磷酸化和CHOP蛋白表达显著增加，说明钠离子通道过度激活诱发了内质网应激反应。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。