藜

As noted above,membrane-stabilizers unexpectedly improved the heart function andprevented ER stress both in vivo and in cultured cells.We know that the membranestability depends on the sodium homeostasis in fact.To investigate whether ER stress isassociated with sodium channel action,which determins the membrane stability,wepretreated H9c2(2-1) cells with veratridine,a sodium channel activator.

上面的研究发现膜稳定剂在体内体外均抑制了内质网应激，并改善了心脏功能，而膜稳定作用实际上是维持细胞钠离子稳态的结果，为了研究内质网应激反应与钠离子活动的关系，我们用一种钠通道激活剂藜芦定刺激H9c2(2-1)细胞，30分钟时GRP78表达增加；24小时时PERK磷酸化和CHOP蛋白表达显著增加，说明钠离子通道过度激活诱发了内质网应激反应。

Radiolabeled pharmacological binding assay showed: 1 BmK AS bound specifically to a single class of non-interacting binding sites on both rat brain and cockroach nerve cord synaptosomes with high affinity and low low capacity. The association of BmK AS with both synaptosomes was quick to reach equilibrium, but the dissociation seemed to be only partial. The specific binding of BmK AS was independent of membrane potential, and couldn't be modified by veratridine. Moreover, the binding of BmK AS could be inhibited by native BmK AS, BmK AS1, BmK IT2 and BmK IT on both synaptosomes, but not or partially inhibited by BmK Ⅰ and suggesting BmK AS type neurotoxins might bind to a distinct receptor site on mammal and insect sodium channels with a similar manner from β-scorpion toxins.

二。蝎毒素多肽配体与哺乳动物和昆虫靶离子通道受体的药理结合特性及其靶结合位点的研究：经放射性标记结合和竞争抑制实验表明：1）BmK AS在大鼠脑和蟑螂神经索突触体上有单一非协同性高亲和力低结合容量结合位点，能快速结合并达到平衡，但仅能部分解离，其结合不依赖于膜电位，也不受藜芦碱调节，天然的BmK AS，BmK AS-1，BmK IT2和BmK IT可抑制〓AS与两种突触体的特异结合，而BmK Ⅰ无或仅有部分抑制效应。

Objective To observe the effects of low dose of veratrine on the discharges of rat hippocampus pyramidal neurons, and to elucidate its possible cytological mechanism.

目的 观察小剂量藜芦碱对大鼠海马CA1锥体神经元放电的影响，并对其诱发产生癫痫样放电的离子机制进行初步探讨。

Veratrine has anticarcinogenic chemical activity in the key stages of the development of cancer cells. It can kill the cancer cells and has no harm to the healthy cells.

白藜芦醇在癌细胞的起始，促进，发展三个重要阶段均有化学防癌的活性，能杀死癌细胞而对正常的细胞无毒害作用。

Methods : Using direct pressure carotid tail artery and indirect pressure , duodenum and gavage to Veratrine . Determination of its normal cats , blood pressure in hypertensive rats and the impast of rapic tolerance .

采用颈动脉直接测压法和尾动脉间接测压法，十二指肠和灌胃给藜芦生物碱，测定了其对正常猫，高血压大鼠血压的影响及其快速耐受性。

Any of various plants of the genus Veratrum having large leaves and green flowers.

各种藜芦属植物的任何一种都具有宽大的叶子和绿色的花朵。

A preliminary study was conducted on the reproductive features of d ifferent populations of Veratrum nigrum along an altitudinal gradient in Don gling Mountains, Beijing.

在北京东灵山地区，沿一定海拔梯度，对藜芦这一雄花两性花同株的多年生草本植物的繁殖特征进行了初步研究。

Veratrum aldehyde synthesis of many drugs intermediates, methyl aldehyde method for raw materials in Champlain, after dimethyl sulfate methylation available to 20% sodium hydroxide as the solvent, 10-11 in the PH value of the under the conditions of synthesis; microwave irradiation is the use of microwave radiation heating to replace the traditional approach to synthesis of a product of methylation reactions, this method does not require solvents, and less by-products, but still need to use 15% sodium hydroxide to adjust pH.

藜芦醛是许多药物合成的中间体，甲基化法以香兰醛为原料，经过硫酸二甲酯甲基化可得，以20%氢氧化钠为溶剂，在PH值为10-11的条件下合成；微波辐射法是利用微波辐射代替传统加热方式进行甲基化反应合成产物，这种方法不需要溶剂，并且副产物少，但仍需要用15%氢氧化钠来调节酸碱度。

Protection of Veratrum nigrum L.

乌苏里藜芦生物碱对肝脏缺血再灌注损伤具有明显的保护作用。

After an intravenous injection of the alkaloid (10—40μg/kg) isolated from Veratrum maackii, the BP, CBF and RBF all decrease...

靜脉注射馬氏藜芦硷10—40微克/公斤，BP下降，CBF及 RBF 減少，血流減少开始显著，5分鉀后慢慢恢复。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。