藏红花酸

Methods Animals were randomly and equally divided into five groups: saline control group, positive drug control group, low-dose, medium-dose and high-dose crocetin group. Animals were anesthetized with urethane (1.2 g/kg), then followed by the perfusion of aconitine (10 μg/mL) through caudal vein in rats, or of ouabain (9 μg/mL) through external jugular vain in guinea pigs in a constant velocity of 0.1 mL/min, and the emergence time of ventricular fibrillation, ventricular extrasystole, ventricular tachycanlia and cardiac arrest were then detected and recorded. The recorded time was then translated to the cumulated amount of aconitine and ouabain. Experimental arrhythmia was induced by rapid injection of 4% CaCl2 (140 mg/kg), and the emergence time, persistence time, incidence and death of arrhythmia after the administration were observed.

将实验动物随机分为生理盐水组，阳性药物对照组，藏红花酸高、中、低剂量组，SD大鼠采用1.2 g/kg乌拉坦麻醉后，从尾静脉匀速(0.1 ml/min)灌注10μg/ml乌头碱溶液，豚鼠麻醉后从颈静脉匀速(0.1 ml/min)灌注9μg/ml哇巴因溶液，观察出现室性期前收缩、室性心动过速、室颤和心脏停搏的时间，然后换算成乌头碱和哇巴因的累积量；快速推注4%氯化钙(140 mg/kg)诱导大鼠心律失常，观察给药后心律失常出现时间、持续时间、心律失常发生数及死亡数。

Objective To study the anti-arrhythmia effect of crocetin and corresponding mechanism.

目的 研究藏红花酸的抗实验性心律失常的作用机制。

In recent years, scientists have discovered the saffron-tipped stamens contained Crocetin, saffron, crocin and saffron aloesin all have strong anti-cancer activity.

近年来，科学家发现藏红花的花蕊中含有的藏红花酸、藏红花、藏红花素和藏红花苦素等都具有较强的抗癌活性。

The concept of equivalent rotationally rigidity is offered and the formula of rotationally rigidity is obtained.

主要做了如下几个方面的工作：对伸臂位于顶部的单层框架—筒体模型进行分析，提出了等效转动约束的概念和转动约束刚度的表达式。

Male cats normally do not need aftercare with the exception of the night after the anesthetic.

男猫通常不需要善后除了晚上的麻醉。