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Then using selective antagonists for mAChR and nAChR, inhibitor of PKC and MAPK, respectively, we probed into the molecular mechanism underlying the regulation of APP processing by HupA.

采用毒蕈碱样乙酰胆碱受体和烟碱样乙酰胆碱受体的特异性拮抗剂,以及PKC和有丝分裂原激活的蛋白激酶(mitogen-activated protein kinase, MAPK)的抑制剂,探讨石杉碱甲调节sAPPα分泌的分子机制。

The purpose of our research is to discuss the significance of TCR clonal rearrangement detection in diagnosis of MF.

本实验的目的是探讨TCR基因克隆性重排检测技术在蕈样肉芽肿辅助诊断中的意义。

Objective To update the clinical characteristics of mycosis fungoides in Chinese patients.

目的分析蕈样肉芽肿患者的临床特征,提高对本病的认识,指导临床工作。

The methylation status of P16INK4a and the expression of its protein may have no relationship with the different type of mycosis fungoides.

P16INK4a基因甲基化状态及蛋白的表达和蕈样肉芽肿的分型可能不具有相关性。

The optimal diagnostic model was developed by support vector machine algorithm with two protein peaks at Mass/Charge 3939 and 5909 respectively. The expression of protein peak at m/z 3939 was higher in chronic eczema and neurodermatitis than in MF, while that at m/z 5909 appeared to express in an opposite way.

结果 从15例蕈样肉芽肿与15例慢性湿疹、神经性皮炎患者的血清蛋白质谱中共检测出329个蛋白峰,从中筛选出30个表达差异有统计学意义(P 0.01)的蛋白标志物。

Pruritus is encountered more or less in all inflammatory dermatoses but is especially common in patients with eczematous dermatitis, urticaria, contact dermatitis, dermatitis herpetiformis, scabies, lichen planus, mycosis fungoides, pediculosis, and xerosis.

所有炎症性皮肤病都存在程度不等的瘙痒,尤其是在湿疹性皮炎、荨麻疹、接触性皮炎、疱疹样皮炎、疥疮、扁平苔藓、蕈样肉芽肿病、虱病、干燥症等疾病中瘙痒相当常见。

A total of 19,781 insect individuals belonging to 959 morphospecies, 145 families and 15 orders were collected. The most abundant orders were Diptera (69.68%), Homoptera (11.19%) and Hymenoptera (10.10%). At the family level, Chironomidae (17.67%), Mycetophilidae (12.32%), Cicadellidae (8.32%), Ceratopogonidae (7.56%), Sciaridae (7.39%) and Cecidomyiidae (5.81%) were the most abundant taxa. Although there were little differences in similarity among the three sampling plots, the dominant orders and families in theses plots differed. The meadow had the highest diversity while the spruce forest had the lowest diversity.

结果:三样区共采集到19,781只昆虫,分属15目、145科、959个形态种;各目的组成百分比,以双翅目(69.68%)、同翅目(11.19%)及膜翅目(10.10%)最为优势;在科的类阶,则是以摇蚊科(17.67%)、蕈蚋科(12.32%)、叶蝉科(8.32%)、糠蚊科(7.56%)、黑翅蕈蚋科(7.39%)及瘿蚋科(5.81%)为优势类群;三个样区的相似度差异不大,但是优势类群则不相同;无论丰度、均匀度及多样性指标,箭竹草原样区均高过於云杉林样区及铁杉林样区。

Materials and MethodsMaterials; 10% formalin fixed, paraffin -embedded tissue samples, including ; MF 59 cases, neurodermatitis 20 cases, chronic eczema 20 cases, parap-soriasis 40 cases, all taken from laboratory of dermatopathology in No.

材料和方法实验材料:来自中国医科大学附属第一床医院皮肤科病理室,10%福尔马林固定、石蜡包埋组织标本:蕈样肉芽肿59例、神经性皮炎20例、慢性湿疹20例、副银屑病40例、临床及病理都符合其疾病的诊断标准;正常皮肤组织标本20例:来自中国医科大学附属第一医院整形外科手术切除的正常人正常皮肤。

ABSTRACT: Objective To isolate muscarinic peptide from Naja atra venom and to study the effect of MP in muscarinic cholinergic receptor.

目的 从舟山眼镜蛇Naja atra蛇毒中分离毒蕈碱样多肽,探讨其与M胆碱受体的关系。

Specific binding is found in tissues where muscarinic receptors are demonstrable pharmacologically .

在药理学方法证明有毒蕈碱样受体的组织中发现了特异的结合作用。

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