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The plasma concentrations of harmine hydrochloride were measured by reversed phase high performance liquid chromatography.

结果 ：大鼠灌胃盐酸去氢骆驼蓬碱胶囊后血浆药物浓度在 0 2 3h左右达峰(2 95 8g·mL-1)，消除半衰期为 5 33h ，灌胃胶囊剂的生物利用度为 19 6 5 %。

The binding enthalpy change, the binding molar ratio and the binding equilibrium constant of harmine with hexamer are obtained.

而对d〓与潜在的抗肿瘤药物骆驼蓬碱的相互作用研究，已得到harmine与d〓结合的摩尔结合焓变，结合常数与结合摩尔比。

3H was labelled in harmine, and the emulsion and solution of 3H-HAR were prepared.

目的：研究去氢骆驼蓬碱（harmine，HAR）静脉注射乳剂在大鼠体内的药动学和小鼠体内的组织分布。

OBJECTIVE To provide biological pharmaceutical basis for dosage forms design of harmine hydrochloride by studying its absorption kinetics in various intestinal segments of rat.

目的 研究盐酸去氢骆驼蓬碱在大鼠胃肠道各段的吸收动力学特征，为其剂型设计提供生物药剂学依据。

Harmine hydrochloride was absorbed perfectly in the duodenum, jejunum, ileum, and colon.

结论盐酸去氢骆驼蓬碱在十二指肠、空肠、回肠及结肠中均能较好地吸收。

Harmine hydrochloride was encapsulated into liposomes by active loading method.

目的 制备高包封率的盐酸去氢骆驼蓬碱脂质体。

Results As the pH value increasing, the solubility of harmine hydrochloride was decreased, while the apparent oil-water distribution coefficient was increased.

结果 随pH值的增大，盐酸去氢骆驼蓬碱的溶解度降低，表观油水分配系数增大；采用主动载药法，包封率随脂质体内外相pH梯度的减少而降低，受孵育温度的影响不大，在药脂比小于1∶5时脂质体包封率达到80%以上。

METHOD The absorption kinetics of harmine hydrochloride from duodenum, jejunum, ileum, and colon were investigated using in situ perfusion method in the rats.

方法采用大鼠在体肠循环法分别研究盐酸去氢骆驼蓬碱在大鼠十二指肠、空肠、回肠及结肠中的吸收动力学特征。

In current study, harmine, an effective alkaloid ingredient in natural product, was extracted from Peganum harmala seeds and its intravenous emulsion was prepared.

的种子中提取分离得到有效的生物碱单体成分去氢骆驼蓬碱（Harmine，Har），并将其制成静脉注射乳剂，简称静脉乳。

KEY WORDS harmine, intravenous emulsion, extract and iso- late, preparation, characteristics, particle size, stability, drug phase distribution, in vitro release, pharmacokinetics, tissue distribution, quantitative evaluation of TDDS

本文对亚微型乳剂一系列主要理化性质的研究方法进行了有益的探索；对靶向给药系统的定量评价做出了积极的尝试；为去氢骆驼蓬碱静脉注射乳剂这一新药的进一步开发研究和应用奠定了科学的基础。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。