萘醌

The cytotoxicity of these compounds were valuated by MTT and SRB methods using three cancer cell lines: HL-60, A-549, P-388. Cyclo-shikonin, and cyclo-alkannin have high cytotoxicity against HL-60.The chiral center of side chain has no effect on their activity. 2- 1-(Acetyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (105) has strong inhibition effect on P-388 cells. 2- 1-(isooctyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (108) and 2- 1-(2-furoyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (112) have high inhibition on A-549.Shikonin (1), alkannin (2), and their derivatives have the structural features of a planar chromophores and short side chain. We examined the ability to inhibit the telomerase.

抗肿瘤活性初步筛选测试采用小鼠白血病P-388肿瘤细胞和人肺癌A-549肿瘤细胞进行，结果表明侧链羟基的手性对抗肿瘤活性无明显影响；有数个化合物具有很好的体外抑制活性，特别是化合物2-（1-异辛酰氧基-4-甲基-3-戊烯基）-5，8-二羟基-1，4-萘醌（108）和2-[1-（2-呋喃甲酰氧基）-4-甲基-3-戊烯基]-5，8-二羟基-1，4-萘醌（112）体外显示对人肺癌A-549肿瘤细胞有强效；2-（1-乙酰氧基-4-甲基-3-戊烯基）-5，8-二羟基-1，4-萘醌（105）对小鼠白血病P-388肿瘤细胞有强效；环紫草素和环异紫草素对人白血病HL-60细胞有强烈抑制作用。

Covalent modification of four isolated alkannin derivatives (alkannin, acetylalkannin,β,β dimethylacrylalkannin and β acetoxyisovalerylalkannin, respectively) on rabbit muscle latate dehydrogenase and yeast Alcohol Dehydrogenase has been studied.

为研究紫草萘醌类化合物的细胞毒性作用机制，从新疆软紫草根中分离出四种紫草萘醌类化合物β，β二甲基丙烯酰阿卡宁(1)，乙酰阿卡宁(2 )，β乙酰氧基异戊酰阿卡宁(3)和阿卡宁(4)。

The inactivation of chironomid larvae in water supply systems was experimented with environment degradable vitamin K3,its main component 2-methyl-1,4-naphthoquinone,and their congener menadione triamintriazine bisulphite.

采用易被环境分解的维生素K3、其基本成分β-甲基萘醌和同系物三氨基三嗪甲萘醌亚硫酸盐，对在给水系统中出现的4龄摇蚊幼虫进行了杀生实验。

The paper presents a study of the inhibitory effects on the growth of Marine Chlorella and toxicity on the luminescent bacteria of Menadione Piperazine Bisulphite and Menadione Triaminotrizine Bisulphite.

研究了哌嗪甲萘醌亚硫酸盐和三氨基三嗪甲萘醌亚硫酸盐对海水小球藻的抑制作用以及对发光细菌毒性试验分析。

Terahertz time-domain spectroscopy has been used to measure the spectral properties of polycrystalline 1,2-naphthoquinone, 1,2- naphthoquinone-4-sulfonic acid sodium salt , Menadione, Plumbagin, Juglone at room temperature.

用太赫兹时域光谱技术研究了室温条件下的萘醌及其衍生物1，2-萘醌、1，2-萘醌-4-磺酸钠、甲萘醌、白花丹素、胡桃醌的光谱特征，得到了各自的吸收谱和折射率。

Menadione piperazine bisulphite; menadione triaminotrizine bisulphte; Marine Chlorella ; luminescent bacteria ; environment-friendly

哌嗪甲萘醌亚硫酸盐；三氨基三嗪甲萘醌亚硫酸盐；海水小球藻；发光细菌；环境友好

In the traditional process,β-methylnaphthalene is oxidized with solution of chromic acid to give β-methylnaphthoquinone. However, a great deal of waste water with chromium will be produced in the process, which is very serious to environment. At the same time, the raw material consumption is great, which lead to the high production cost. Furthermore, by-product 6-methyl-1, 4-naphthoquinone will be produced, which is difficult to be separated completely and be utilized solely.

传统的生产工艺是用铬化物氧化β-甲基萘制备β-甲基萘醌，此工艺在生产过程中会产生大量的含铬废水，处理繁杂困难，对环境污染十分严重，并且原料消耗大，成本高，反应过程中的副产物6-甲基-1，4-萘醌未能加以彻底分离和利用。

It's has been reported that lactoquinomycin and frenolicin B, analogues of kalamycin, can inhibit AKT for the pyran naphthoquinone skeleton they have. We found that although kalamycin has pyran naphthoquinone skeleton, but did not suppress AKT and its downstream signal system, then we make a sytematic analysis on the in vitro anti-tumor effect and mechanism of kalamycin.

有报道其类似物lactoquinomycin和frenolicin B是肿瘤靶点AKT抑制剂，并由此推断吡喃萘醌骨架在AKT抑制过程中发挥主要作用，我们发现虽然卡拉霉素含有吡喃萘醌骨架，但是并不抑制AKT及其下游信号系统；继而对卡拉霉素的体外抗肿瘤作用及其机理进行了系统的分析。

Juglone (5-hydroxy-1, 4-naphthaoquinone) is one of the active substances that was extracted from Juglans mandshurica Maxim.

胡桃醌（5-羟基-1，4-萘醌）是从核桃楸中提取分离出来的一种萘醌类活性物质。

First, 5-nitro-1 and 4-naphthoquinone are prepared through nitration and oxidization of naphthalene, and then through reduction of nitro into amide, diazotisation of the amide and hydro-lytic action of diazo salt, the juglone is made.

萘经过硝化、氧化生成5-硝基-1，4萘醌，然后硝基还原成氨基、氨基重氮化、重氮盐再水解，最终用新方法制得胡桃醌。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。