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Gene mutations were detected in 25 patients and a 18-year-old girl among 16 families. Trinucleotide repeats of CAG were 73~79. The fragments of abnormal alleles were 380~402bp, and all patients were heterozygous. The copy numbers of normal alleles were 18~40, fragments from 202~270bp. SCV reduction was much obvious compared to MCV, MCV and SCV in lower limb ?ere much more slow than that in upper's. BAEP, VEP were also delayed in latency. The anticipation in parental sex bias were much more obvioius than that in matental's. Cerebellar ataxia was most severe, the next were dysarthria and bulging eyes. Amytrophy was seen only in bed ridden patients. Cerebellar atrophy was more severe than brain stem, cord atrophy was n't observed in all MJD.

结果检出10个家系25例病人及1例症状前18岁女孩有MJD基因突变,CAG三核苷酸重复73~79次,异常等位基因片段长380~402bp,均为杂合子;正常人CAG三核苷酸重复18~40次,等位片段长200~270bp,电生理发现MJD的SCV减慢比MCV明显,而下肢的MCV、SCV又较上肢明显,BAEP、VEP均有不同程度的潜伏期延长或波的异常;MJD的父亲遗传早于母亲,进展也较块,临床以小脑性共济失调为突出症状,其次为构音障碍、突眼等,肌肉萎缩仅见于晚期病人;MRI示小脑萎缩较明显,脑干萎缩并不严重,未见明显的颈髓萎缩

Tooth-correct, because of the reason of the Jiao tooth machine, majority all will the engine gum atrophies of linger effect, correct process in or the Jiao tooth uses tooth gold behind, the tooth gold can make the atrophic gum directly absorbed enough nourishment when contains and make atrophic gum reborn thus and shut to match appear because of tooth-correct of difficult see a gum of blind side, avoid bring because of the tooth-correct of the gum atrophy linger effect.

牙齿矫正,由于矫牙器的原因,多数都会引擎牙龈萎缩的后遗症,矫正过程中或矫牙后使用牙齿黄金,牙齿黄金在口含的时候可以让萎缩的牙龈直接吸收到足够营养,从而令萎缩的牙龈再生,闭合因牙齿矫正而出现的难看牙龈缝隙,避免因牙齿矫正带来的牙龈萎缩后遗症。

Results In the medium and high dose F0 groups, it was observed that the atrophy and incrassation of seminiferous tubule, decrease of spermatogenesis, hyperplasia of interstitial tissue, especially in high dose groups spermatozoon abnormality and nucleolus concentration in the rats testis after DU ingestion for 14 months. The changes became more severe with the prolongation of DU ingestion. Such changes occurred in filial rats (F1) after DC ingestion for 5 months. In the medium and high dose F0 groups, it was observed that a little atrophy of kidney glomerulus, hyperplasia of interstitial tissue after DC ingestion for 14 months, and kidney glomerulus fibrosis happened after DC ingestion for 20 months, such changes occurred in filial rats (F1) after DC ingestion for 5 months In the medium and high dose F0 groups, splenic germinal center and periarterial lymphatic sheaths were hyperplasia , companies with lymphopoiesis after DC ingestion for 7 months, splenic white pulp became more small and sparse after DC ingestion for 20 months.

结果 F0代的中、高剂量组大鼠摄入贫铀14个月后可见雄性的精曲小管萎缩,管壁增厚呈空虚网状,生精细胞层次减少,间质细胞增生,但仍见有精子生成;高剂量组可见到精子呈异型性改变,细胞核浓缩深染,且随着摄入时间延长改变愈趋明显;F1代大鼠摄入贫铀5个月后就有上述改变且更为严重。F0代中、高剂量组大鼠摄入贫铀14个月后肾小球轻度萎缩,间质增生明显,20个月时肾小球萎缩纤维化;F1代大鼠摄入贫铀5个月后就有上述改变。F0代中、高剂量组摄入贫铀7个月时脾脏生发中心和淋巴鞘增生,淋巴母细胞增生活跃,20个月时脾小体减少,生发中心稀疏;F1代大鼠摄入贫铀早期和晚期有类似改变。F0和F1代高剂量组摄入贫铀早期肝脏有炎症细胞浸润,晚期骨髓有核细胞减少,脂肪细胞增加。

Transcription, western, and immunohistochemical analysis showed increased levels of dystrophin transcript and protein, and correct localization at the sarcolemma.

用免疫组织化学分析用纳米作为载体进行寡聚核苷酸递送的实验鼠抗肌萎缩蛋白基因RNA和抗肌萎缩蛋白的水平得到提高,而且恢复了抗肌萎缩蛋白在肌肉细胞膜上的正确位置。

Fundus photographs showed myopic chorioretinal atrophy in eight study eyes (47%), including diffuse atrophy in four eyes (24%) and patchy atrophy in four eyes (24%). The IS/OS defects on FD-OCT were accompanied by myopic chorioretinal atrophy in three (60%) of five eyes.

眼底成像显示8只眼(47%)有近视性脉络膜视网膜萎缩,其中包括4只眼(24%)为弥漫性萎缩,4只眼(24%)为斑块状萎缩。5只眼中有3只眼(60%)的傅立叶域光学相干成像显示为光感受器内外节缺损伴随近视性脉络膜视网膜萎缩

More pessimistically believe that the market's量能萎缩too fast, do not rule out the market has been "finish off" the.

更悲观地认为,市场量能萎缩过快,不排除市场已&玩完&了。

Because the gum atrophies part only a tooth seldom of, usually is all one, now that have a tooth because of atrophying but shed off, periphery of tooth's appearing an atrophic risk is very big, if is a sustaining good tooth loose, will make the whole row roasted a porcelain tooth to shed off together.

因为牙龈萎缩部分很少只有一个牙齿的,通常都是一片,既然有个牙齿因萎缩而脱落,周边的牙齿出现萎缩的危险性是非常大的,如果作为支撑的好牙松脱,就会导致整排烤瓷牙一起脱落。

Great majority tooth week the burning sufferer all accompanies with the gum atrophies of symptom, the survey discovers, in the crowd over 45 years of age, above 90% exists the gum of different degree to atrophy a phenomenon, while the gum atrophy, also always drive mouth cavity medical science the field see to deteriorate a phenomenon for the physiology that can not converse.

绝大多数牙周炎患者都伴随着牙龈萎缩的症状,调查发现,在45岁以上的人群,90%以上存在不同程度的牙龈萎缩现象,而牙龈萎缩,也一向被口腔医学界视为不可逆转的生理退化现象(对于不可逆转的观点,显得已经有点过时了,对于这个问题,将在以后的文章部分专门说明)。

The reason that the gum atrophies, though knows to is a vitamin to lack, but usually atrophies a sufferer in the gum body up, hardly discover the whole body comprehensive symptom that the vitamin lacks, at clinical up, pass a great deal of food vitamin, cure the effect that the gum atrophies also poor.

牙龈萎缩的原因,尽管知道是维生素缺乏,但是通常在牙龈萎缩患者身上,很少发现维生素缺乏的全身综合症状,在临床上,通过大量服食维生素,来治疗牙龈萎缩的效果也不佳。

3The fourth ventricle enlarged, the cisterns in front of pons varolii and bulb widened, which could find in all fifteen cases.(4)other features: severalsubcortical lacunar infarctions could find in three cases, and five cases found pallium atrophy, which was less serve than cerebellum and bridge of Varolius were.

其他表现:3例患者有皮层下多发点状长T1长T2腔隙性脑梗塞;5例患者有大脑皮层萎缩,为轻度萎缩萎缩程度明显轻于小脑、桥脑。

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