菲尔森

Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞，导致细胞生长的抑制和凋亡罗伯托利，斯特凡Purgato ，苏埃洛卡默琳，拉菲尔Fronza ，梅奥尼博洛尼亚，西蒙娜Alboresi ，莫妮卡弗兰索尼，罗伯托Corradini ，斯特凡诺斯福尔扎，安德烈Faccini ，杰森先生Shohet ， Rosangela Marchelli ，和安德烈Pession儿科，博洛尼亚大学，圣' Orsola -马尔皮基医院，博洛尼亚，意大利；有机部和工业大学化学帕尔马，帕尔马，意大利和3Center的细胞和基因治疗，德州儿童癌症中心， Baylor医学院，得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞，针对一个独特的序列反义DNA链的第2外显子，并与在MYCN 其氨基端为核定位信号肽。

June 1997: Tyson is disqualified after the third round of match with Evander Holyfield after he bites his opponent twice, once on each ear.

1997年6月：在第三轮比赛后泰森被取消资格，因为泰森在与霍利菲尔德的比赛中咬他的对手两次，每个耳朵各一次。

Caption :June 1997: Tyson is disqualified after the third round of match with Evander Holyfield after he bites his opponent twice, once on each ear.

描述：1997年6月：在第三轮比赛后泰森被取消资格，因为泰森在与霍利菲尔德的比赛中咬他的对手两次，每个耳朵各一次。

STEN guns were made not only in Royal Small Arms factory in Enfield; other makers included famous British gunmaking company of the time BSA Ltd, as well as Royal Ordnance Arsenal in Fazakerly, England, and Long Branch Arsenal in Canada.

司登枪不仅在小武器皇家恩菲尔德工厂；其它厂商，包括著名的是当时英国gunmaking公司商业软件联盟有限公司，以及皇家兵工厂阿森纳Fazakerly，英国和龙科阿森纳在加拿大。

The 12-round Bout between Tvson and South African Boxer Botha is to be held at the MGM Grand in Las Vegas 0n January 16. It will be Tyson's first fight since June,1997,when he Bit Holyfield's ears during a world heavyweight title contest.

泰森和南非选手博萨之间12回合的比赛将于1月16日在拉斯维加斯米高梅酒店举行，这是泰森自1997年6月在一次世界重量级拳击赛中咬霍利菲尔德耳朵后首次出场。

Corporal Kerry Brook is consoled by Corporal Claire Vogel at The Armed Forces Memorial as they view the name of their fallen friend and colleague Private Kevin 'Tommo' Thompson' who died from the injuries he sustained in Iraq in 2007 on November 11, 2009 in Lichfield, United Kingdom.

下士安慰克里布鲁克是在武装部队纪念，因为他们认为他们的朋友和同事下降私人凯文托莫'汤普森'谁伤害他从伊拉克持续09年11月11号2007年在利奇菲尔德去世名称按下士克莱尔沃格尔，英国。

However, I would like to acknowledge, especially, B. Gentry Lee; the Cosmos production staff, including the senior producers Geoffrey Haines-Stiles and David Kennard and the executive producer Adrian Malone; the artists Jon Lomberg (who played a criticalrole in the original design and organization of the Cosmos visuals), John Allison, AdolfSchaller, Rick Sternbach, Don Davies, Brown, and Anne Norcia; consultants Donald Goldsmith, Owen Gingerich, Paul Fox, and Diane Ackerman; Cameron Beck; the KCET management, particularly Greg Andorfer, who first carried KCET's proposal to us, Chuck Allen, William Lamb, and James Loper; and the underwriters and co-producers of the Cosmos television series, including the Atlantic Richfield Company, the Corporation forPublic Broadcasting, the Arthur Vining Davis Foundations, the Alfred P.

然而，我还要特别感谢 B·金特里·李及《宇宙》电视系列片全体制作人员——包括老一辈制片人杰弗里·海恩斯－斯太尔斯和戴维·凯纳德以及监制人艾德里南·马龙，画家乔恩·龙伯格（他那富有独创性的布景设计与组织能力对《宇宙》的拍摄起了关键性的作用）、约翰·阿利森、阿道夫·沙勒、里克·斯特恩巴赫、唐·戴维斯、布朗和安妮·诺西亚；顾问唐纳德·戈德史密斯、欧文·金杰里奇、保罗·福克斯和黛安妮·阿克曼、卡墨伦·拜克；KCET管理人员，特别是格雷格·安多尔弗（他首先把KCET的建议传达给我们）、丘克·艾伦、威廉·拉姆和詹姆斯·洛珀，《宇宙》电视系列片的担保人和合作制片人，其中包括大西洋里奇菲尔德公司、公共广播公司、阿瑟·维宁·戴维斯基金会、艾尔弗雷德·斯龙基金会、英国广播公司和波利特尔国际组织。

Gregg has performed and recorded with an amazing variety of artists including Santana, Ringo Starr, James Taylor, David Lee Roth, Toto, Joe Satriani, Don Henley, Hans Zimmer, Keiku Matsui, Gino Vannelli, Tania Maria, Brian Wilson, Frank Gambale, Carole King, Robin Zander, Yarborough and Peoples, Andy Summers, Linda Rondstat, Steve Lukather, The Mustard Seeds, David Garfield, Enrique Iglesias, Larry Carlton, Pat Boone's Heavy Metal Big Band, Tribute to Jeff Porcaro, Celine Dion, Steve Vai, and many others.

格雷格的表现和记录的一个了不起的各种各样的艺术家，包括桑塔纳， ringo斯塔尔，詹姆斯泰勒，大卫李罗斯，东陶，乔satriani ，唐亨利，汉斯兹蒙， keiku松井，吉诺vannelli ， tania玛丽亚，布赖恩威尔森，坦诚gambale ，卡罗尔国王，罗宾桑德尔， yarborough和人民，安迪萨默斯，琳达rondstat ，史蒂夫lukather ，芥菜种子，大卫加菲尔德，恩里克伊格莱西亚斯，拉里卡尔顿，八布恩的重金属大乐队，赞扬杰夫porcaro ，席琳狄翁，史蒂夫奥钢联，和许多其他问题。

In fact, Crocker's edging of Phelps put Crocker on the relay the next day with fellow Longhorns Brendan Hansen and Aaron Piersol.

事实上，正是击败了菲尔普斯，才让科洛克能在第二天与布兰登·汉森以及阿伦·佩尔索尔一起参加接力。

Jonathan Swift's "Gulliver's Travels" cruelly satirised Walpole's regime while John Gay's "The Beggar's Opera" delighted its huge audiences with its irreverent commentary on his cynical corruption. Alexander Pope and Henry Fielding also had much to say on Walpole's administration.

乔纳森斯·威夫特的《小人国历险记》( Gulliver's Travels )中不留情面地讽刺了他沃波尔的政府；而约翰·盖依的《乞丐歌剧》( The Beggar's Opera )则不想干地评论了下他的严重腐败，以此娱乐读者；亚历山大·蒲伯和亨利·菲尔丁也就沃波尔的管理说了不少。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了