菌血症

PART ONEInvestigation on Hp CagA+ strain infection condition and pathogenesis risk analyze in patients of carotid atherosclerosisObjective To observate pathological changes of carotid atherosclerosis as well as Hp infection situation, examinate blood fats, blood serum hs-CRP, blood plasma YKL-40, blood serum sCD14, analyze relations between Hp or Hp CagA+ strain and carotid atherosclerosis, and explore possible mechanism of carotid atherosclerosis caused by infection.

然后进行基础动物实验，应用Hp CagA+菌株干预高脂血症大兔，建立Hp CagA+菌株感染致兔颈动脉粥样硬化模型，进行血清Hp抗体、hs-CRP、血浆YKL-40水平检测、斑块内Hp DNA，进一步求证Hp CagA+菌株感染和颈动脉粥样硬化形成的相关性，Hp CagA+菌株感染是否可促进颈动脉粥样硬化的形成，深入探讨其可能机制，以期为颈动脉粥样硬化形成的病因学研究提供实验基础，为临床治疗颈动脉粥样硬化提供新的策略，从而完善其防治模式。

Infection positions are inclined to lead to abscess, then invade into organs and blood stream and results in organic abscess for marion, pyemia is another clinical character of Chromobacterium violaceum infection.

可引起感染部位脓肿，并可侵入体内各脏器及血液引发脏器的脓肿，脓毒血症是该菌感染的临床特症，重者可引起各脏器功能衰退，中毒性休克甚至死亡。

According to the spetial conformational analysis and physical/chemical property analysis and by the aid of computer it can make molecular design of mimic polypeptide and designs the polypeptide molecule with activity for neutralizing LPS, and adopts the solid phase polypeptide chemical synthesis method to synthesize antibacterial/antiendotoxin mimic peptide with total or partial BPI bio-function.

本发明公开了通过计算机模拟设计、人工合成的66个抗菌／抗内毒素模拟肽，根据对BPIN端三个LOOP区的空间构象分析及物理化学性质分析，在计算机辅助下进行模拟多肽的分子设计，设计出具有中和LPS活性的多肽分子，用固相多肽化学合成方法合成抗菌／抗内毒素模拟肽，本发明的抗菌／抗内毒素模拟肽具有全部或部分BPI的生物功能，可以用于治疗G－细菌感染、人内毒素血症，具有分子量小、可以稳定重复生产的特点。

RESULTS Sixty fungal strains were isolated from blood.Candida was the predominant pathogenic organism(86.7%),6 cases had mixed infection causing by two fungal species(11.1%).Twenty two cases had concomitant bacteremia(40.7%).Overall mortality rate was 68.5%,directly related mortality rate in treatment group was significantly lower than that in nontreatment one(28.9%vs.88.9%,χ2=11.268,P＜0.01).Effective rate of amphotericin B was 68.8%,fluconazole 70.8%,combined treatment 80.0%.

结果 54例患者血微生物培养共获得真菌菌株60株，念珠菌是主要病原体，占86.7%；6例(11.1%)为两种真菌混合感染；22例(40.7%)伴随细菌血症；总病死率68.5%，真菌血症相关病死率治疗组28.9%，未治疗组88.9%，两组比较χ2=11.268，P＜0.01；两性霉素B及氟康唑治疗有效率分别为68.8%和70.8%，两者联合治疗有效率为80.0%。

The data of children who were diagnosed as nosocomial candidaemia, were examined in this study.

研究分析了医院内诊断有念珠菌血症儿童的数据。

In conclusion, our results showed urinous supernatants should be used as candidate to diagnose candidemia by PCR.

综上所述，我们证实在血浆中存在游离DNA，同时发现在尿上清中也存在游离DNA。以前的研究证实尿培养可能对念珠菌血症无诊断意义。

The primary endpoint was the composite of infectious complications--ie, infected pancreatic necrosis, bacteraemia, pneumonia, urosepsis, or infected ascites--during admission and 90-day follow-up.

主要终末点是综合的传染性并发症——即传染肺炎菌血症、坏死、胰腺癌、urosepsis或传染水臌——在入学和90天的随访。

There were 16 amputations including Gustilo IIIB in 2 patients, Gustilo IIIC in 9 and Tscheme Ⅲin 5 according to Gustiln classification or Tscheme classification.Four patients who received amputation in field or at tent hospital developed infection and had to receive amputation again at a higher level on the limb and drainage of open wounds because of a higher infection rate due to the amputation location.Ten patients received first amputation at higher levels with open wound at station hospital but only 2 manifested infected incision.High level amputation with one stage closure was done in 1 patient who was infected and suppurated after operation and even developed bacteremia.

截肢部位16处，GustiloⅢb 2例，GustiloⅢc 9例，Tschernen Ⅲ 5例。4例现场或帐篷截肢伤员术后均发生感染，行二次、高位、开放截肢手术。10例后方截肢伤员行一次性、高位、开放截肢，其中2例发生感染。1例后方截肢伤员进行的是高位截肢I期闭合切口，结果术后感染、切口流脓，出现菌血症。

The victim dies a few days later of septicemia, then the keen-scented dragon sniffs out the putrefaction and eats the rotting corpse at its leisure.

数天后，被咬的受害者会死于菌血症，然后嗅觉灵敏的巨蜥会闻到尸体的腐败味，想要进食的时候，就来吃腐肉。

The clinical features of melioidosis vary, raging from localized, benign disease to fulminent septicaemia.

在临床上的表现是多样性，从局部的感染至严重的菌血症。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。