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Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

But when needled and prodded by media members -- as they are known to do sometimes -- he acknowledged that it was something he did not know would ever occur in his career.

但当记者针锋相对的逼问下--他们已经知道科比获得MVP了--科比承认他从来没想能在他的职业生涯中获得这个奖项。

To dissect single cells promising to culture from tissues, we researched the time of hydrolyzation of the tissues by tryposin, the result showed that the optimum time of hydrolyzation of the tissues was 5~10min when pretreated with 0.25% tryposin under the optimum conditions of pH8.0 at 37 C.We cultured four tissues: embryo at mediat-anaphase, head of high-age nymphae, spermary and ovary of adult.

组织块分离出来后，为了能获得单个的、有培养前景的细胞，本实验又研究了低浓度的胰蛋白酶在其最适温度和最适pH条件下，获得分离程度适宜的组织块的不同酶解时间，结果0.25％的胰蛋白酶在37℃、pH8.0的条件下酶解组织块的最适时间是5～10min。

Company research and technological power, and with famous scientific research institutes to establish long-term technology partnership, with full absorption of Italy, Germany, the United States, law, such as advanced technology and world-class scientific research on the foundation, give full play to "ocote people" wisdom, after years of painstaking research and development, in 1998 launched the first Chinese shoes like computer cutting machine, and obtained Chinese patent for the product and subsequently continued with the introduction of the first Chinese apparel computer cutting, China's first CD Units Paper Machine, China's first computer carton Carton Units proofer, plotter, such as Jay-Jay series of products and to obtain the product of Chinese patents, by the broad masses of the footwear industry, garment industry, the advertising industry, printing industry, the luggage industry manufacturers, such as preferences and praise.

公司科研技术实力雄厚，并与国外著名科研院所建立长期技术合作关系，在充分吸收意、德、美、法等世界一流先进技术和科研成果的基础上，充分发挥&奥科人&的聪明才智，经过多年苦心研制开发，于1998年推出了中国第一台鞋样电脑切割机，并且获得了该产品的中国专利权，其后相续推出了中国第一台服装电脑裁床，中国第一台裁皮机，中国第一台纸箱纸盒电脑打样机，绘图仪等奥科系列产品，并且获得了该产品的中国专利权，受到广大鞋业、服装业、广告业、印刷业、箱包业等厂家的喜好和好评。

These estimates can be obtained using only widely available product-level and aggregate consumer-level data, and they are consistent with a structural model of equilibrium in an oligopolistic industry.

这些评估能够获得，从非常宽泛的、可以获得的产品层面和消费层面的数据，并且他们和一种垄断产业的均衡结构模型相适应。

Estimates from our framework can be obtained using only widely available product-level and aggregate consumer-level data, and they are consistent with a structural model of equilibrium in an oligopolistic industry.

这些评估能够获得，从非常宽泛的、可以获得的产品层面和消费层面的数据，并且他们和一种垄断产业的均衡结构模型相适应。

In 1975 he founded his own musical ensemble, the Orchestra of Lancy in Geneva (Orchestre de Lancy-Genève). This marked the beginning of a long and fruitful enterprise. Two years later, in 1977, he initiated the "Estivales Océans" on the French Atlantic coast, a festival at which he and his orchestra would play the leading role for more than twenty years.

罗贝托。妫滞胖富蛹嫘√崆偈，在自己的出生地阿根廷的布伊诺斯艾利斯接受的音乐教育，并获得了很多大奖，例如：圣达菲比赛优异奖(演奏德沃夏克的小提琴与交响乐协奏曲)以及因演奏德国作曲家的小提琴协奏曲而获得贝多芬奖学金，等等。

Among them, the role of orthographic processing skills is the most important, whatever in single-character recognition or in comprehension.

二、正字法加工技能对汉语阅读获得非常重要，特别是在阅读获得的初期。

In journalism from the University of California, Berkeley, where she studied with China scholar Orville Schell.

她在美国缅因州鲍登学院获得了文化人类学和艺术历史学的学士学位，并在伯克利的美国加州大学获得了新闻学硕士学位。

Results A good stability can not he obtained with wire osteosynthesis in the treatment of midface fractures.

结果 钢丝骨间结扎不能获得良好的稳定性，而小钛板坚固内固定则可重建面中份骨骼的支柱结构，获得足够的三维稳定性和重建理想的面部外形。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。