药物的

Unlike standard chemotherapy,treatment with the molecular targeted anti-tumor agents is associated with an increased incidence of dermatological toxicities.

分子靶向抗癌药物的毒副作用迥然不同于传统的细胞毒药物，尤其是其最为常见的皮肤毒性，可引发身体和心理的明显异常，导致药物的减量或中断从而影响治疗的效果。

Pharmaceutical excipients were used as a vehicle of water-soluble, liposoluble and even indissolvable drugs with low toxicity and satisfactory biocompatibility. Furthermore, it provides direction and method to decrease efflux of cytotoxic drugs from the cancer cells, promote the effect of clinical therapeutic efficacy, recover the sensitivity of the cancer cells to the cytotoxic drugs, and improve the characteristics of pharmacokinetics of some drugs such as increasing the absorption of some orally drugs, decreasing the renal clearance and hepat-clearance.

此外，通过抑制P-gp的外排功能，一些药用辅料具有逆转肿瘤细胞多药耐药的作用，为临床提高抗肿瘤药物的疗效，减少肿瘤细胞对药物的外排，提高其对药物的敏感性，提供了研究方向和试验手段。

Distribution of an ionizable drug across a membrane at equilibrium is determined by the drug's pKa （the pH at which concentrations of un-ionized and ionized forms of the drug are equal） and the pH gradient, when present.

一种能解离的药物透过生物膜到达分布平衡取决于药物的pKa（药物的非解离型和解离型浓度相等时的pH）和当时的pH梯度。

Distribution of an ionizable drug acro a membrane at equilibrium is determined by the drug's pKa （the pH at which concentratio of un-ionized and ionized forms of the drug are equal） and the pH gradient, when present.

一种能解离的药物透过生物膜到达分布平衡取决于药物的pKa（药物的非解离型和解离型浓度相等时的pH）和当时的pH梯度。

Experiment resultsindicate that, the hydrogen bonds between hydroxyl of PVA and salicylic acid leads to thecompatibility between them. The drug release rate is accelerated with the rise oftemperature and decreased with the increase of drug loadage. The fitting result suggests afirst-order kinetic equation for salicylic acid release.

结果表明：PVA羟基与水杨酸之间氢键作用有利于两者的相容性；随着介质温度的上升，药物的释放速率增加；随着药物装载量的增加，药物的累积释放率降低；PVA水凝胶中水杨酸的释药规律符合一级释放模型。

The drugs in the preceding examples would have little, or very reduced, efficacy in patients who are not infected with CCR5-tropic HIV-1 or who do not overexpress HER2. In contrast, testing may be recommended to avoid the risk of excessive drug sensitivity or toxicity. Two drugs in this category are warfarin and rasburicase.

前述例子中，不是CCR5-tropic HIV-1之 HIV感染，或者不是过度表现的HER2的病患，药物的效果很小、很低；相对的，建议检测以避免过度的药物敏感或毒性；这一类的另外两个药物有warfarin和rasburicase。

Objective and Methods To evaluate mechanisms of drugs commonly used in the treatment of septicemia, giving antibiotics including Minocycline (10 mg/kg), Clindamycin (10 mg/kg), Cyclosporin (15 mg/kg) and Platonin (10 mg/kg) to septicemic rat injected with LPS. Clinical improvement, blood pressure, heart rate, survival time are assessed, and the amount of endogenous NO production is determined.

本实验之目的是要探讨在临床上常用於治疗败血症的数种药物，可能的作用机转；藉由注射老鼠LPS模拟败血症前，先给予Minocycline，Clindamycin，Cyclosporin，Platonin等药物治疗，评估药物的改善状况，同时观察血压、心跳、动物存活时间及侦测体内NO的生成量，来比较给药与否之差异，且针对变化的可能原因来探讨。

In recent years, with the development of supercomputer and the software of chemometrics, especially, in depth research and extensive use of chemometrics, NIR becomes the spectral technique with the fastest development and most remarkably, so its applications are more and more abroad in every field.

仅在药物分析领域中的应用范围就相当广泛，它不仅适用于药物的多种不同状态如原料、完整的片剂、胶囊与液体等制剂，还可用于不同类型的药品，如蛋白质、中草药、抗生素等药物的分析。

The newly formed company in 2007 of non-tumor drug sales force to promote a narcotic analgesic medication surgery atracurium amines, sevoflurane, speed cards and anti-infective drugs such as clarithromycin sustained-release tablets in the hospital market, the rapid volume growth, the company's 2008 profit growth point of the main one.

在2007年非新成立的公司肿瘤药物的销售队伍，促进手术麻醉镇痛药物阿曲库胺，七氟醚，速度卡和抗感染类药物，如克拉霉素持续的医院市场缓释片，快速量的增长，公司2008年利润的主要增长点之一。

In South Africa's Minister of Health and others versus Treatment Action Campaign and others, 2002, the Treatment Action Campaign, having teamed up with other NGOs such as legal resource center, children's rights center, the Community Law Centre, the Institute for Democracy in South Africa and Cotlands baby sanctuary, protected the rights and interests of AIDS patients and susceptible groups by transporting low-cost AIDS drugs, oppose pharmaceutical association's attempt to stop legislation supporting affordable AIDS drugs and demanding the government to make the drug nevirapine available at all medical facilities to prevent mother-to-child HIV transmission.

南非2002年卫生部长等诉治疗行动运动组织等（Minister of Health and Others v Treatment Action Campaign and Others）案件中，治疗行动运动组织联合其他非政府组织如：法律资源中心、儿童权利中心、社区法律中心、南非民主学会以及Cotlands婴儿避难所等，通过运送低价艾滋病药物、反对医药制造协会通过诉讼的手段阻止立法对于普通的和较廉价的艾滋病药物的支持，要求政府在所有国家医疗机构中提供Nevaripine这种被广泛推荐用来减少母婴之间传播的抗逆转录病毒药物等方式，来维护艾滋病患者和易受艾滋病感染群体的利益。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失