药物的

Age, sex, activity, genetic phenotype, stress, disease （eg, achlorhydria, malabsorption syndromes）, or previous GI surgery can affect drug bioavailability.

年龄、性别、活动情况、遗传表型、应激、疾病（如胃酸缺乏，营养不良综合征）或既往胃肠手术等均能影响药物的生物利用度。

Age, sex, activity, genetic phenotype, stre , disease （eg, achlorhydria, mala orption syndromes）, or previous GI surgery can affect drug bioavailability.

年龄、性别、活动情况、遗传表型、应激、疾病（如胃酸缺乏，营养不良综合征）或既往胃肠手术等均能影响药物的生物利用度。

Modern beautiful model treatment is to use with injector " gun " the nutrient medicaments that wants the skin place of thimbleful, through tailor-made " gun " infuse arrives subcutaneous tissue, the course undertakes do not have the stimulation of painful and effective physics, chemistry and medicaments to the skin, by subcutaneous tissue is direct and after apace is absorbed, stimulative airframe fights consenescence and reborn action, according to different hairdressing motive, and use nutrient drug also not identical.

现代的美塑疗法是用一支附有注射器的"枪"将极少量的皮肤所需的营养药物，通过特制的"枪"注入到皮下组织，经过对皮肤进行无痛而有效的物理。化学和药物的刺激，经由皮下组织直接而快速地吸收后，促进机体抗衰老及再生的作用，依不同的美容作用，而使用的营养药剂亦不相同。

"Apraclonidine, a selective alpha-2-agonist, was developed to lower intraocular pressure and minimize the systemic side effects associated with the use of its parent drug, clonidine," write Patrick Watts, MBBS, MS, from the University Hospital of Wales in Cardiff, United Kingdom, and colleagues."An investigation of the site of action of apraclonidine incidentally uncovered a reversal of anisocoria in patients with absent sympathetic innervation of one pupil due to its alpha-1-effect on a pupil with denervation supersensitivity.... The easy availability of apraclonidine, its mild alpha-1-agonist activity, and its hitherto benign safety profile has encouraged its use as a first-line drug in the diagnosis of oculosympathetic paralysis."

英国加地夫市威尔斯大学附设医院的外科学硕士Patrick Watts及研究同仁指出，Apraclonidine是一种选择性的α-2-拮抗剂，是用来降低眼内压，并减少其母系药物降保适使用上的相关全身性副作用；在一项针对apraclonidine作用位置的研究中，因其单侧瞳孔神经切除之α-1-效应，而附带提出单侧瞳孔无交感神经支配患者之瞳孔大小不等为可逆转，apraclonidine之高可利用率，其轻微的α-1-拮抗活性，以及迄今良好的用药安全档案，更强化其作为视交感神经瘫痪诊断第一线药物的使用率。

Bahar said that more than half of eligible patients, or their parents or guardians, refused to enroll in the study because they were uncomfortable with using an antidepressant medication of any kind, citing negative reports in the media about their side effects and the Food and Drug Administration's formal 2004 "black box" warnings regarding the increased potential for suicide in children using antidepressants.

bahar说，有一半以上符合资格的病人，或他们的父母或监护人，拒绝参加在研究，因为他们不舒服与使用抗抑郁药物的任何形式的，引用的负面报道在媒体上对他们的副作用和美国食品和药物政府当局的正式的2004年&黑匣子&警告，就增加了潜在的自杀在儿童使用抗抑郁药。

It is generally accepted that there are three kinds of binding modes for small molecules to DNA, which refer to intercalative binding, groove binding and electrostatic force.

对于小分子来说，分子的哪一部分插入DNA是很重要的因为它不仅有利于探索和开发新的核酸探针，而且有助于从分子水平上了解抗癌药物的作用机理，并为设计合成具有应用前景的高效的疾病诊断和化疗药物提供有用的信息。

Topotecan is an effective agent for SCLC when used as monotherapy or in combined treatment, but myelosuppression such as leucopenia and thrombopenia was relatively severe. Although it has been recommended as a second-line agent for recurrence of sensitive SCLC, more clinical trials are needed to define its role in first-line treatment.

拓扑替康治疗小细胞肺癌有确切临床疗效，无论是单药还是与其他药物的联合用药均具有与当前一线经典方案相当的疗效，但具有相对高的致白细胞和血小板下降的骨髓毒性，已被认为是治疗化疗敏感的小细胞肺癌患者复发的二线推荐药物，但是作为一线用药仍然需要更多的实践来证实。

Next, regarding question two, because present uses the injection contraceptive the method to maintain this population the stability, moreover already did not have the individual to move away or the situation which poaches, for this reason we transform this populations stability to ask this population every years newborn baby quantity to subtract this year death individual the quantity differential value; Moreover from this population year quantity with this year the end of the years quantity differential value, when tends 0, namely thought that this community individual quantity is stable, thus the question stability problem transforms to ask simple targets optimization problems model building; Carries on using MATLAB to the model obtains, obtains, when did not consider when uncertainty factor influence must inject the medicine female animal quantity is 276 heads, but when had considered after twin and by duplicate injection these two uncertainty factor influence, obtains must inject the medicine female animal quantity is 352 heads, including 110 are by the duplicate injection.

其次，对于问题二由于现在采用注射避孕药的方法来维持该种群的稳定，而且已经没有个体被运走或被偷猎的情况，为此我们把该种群的稳定性转化为求该种群每年的新生幼仔的数量减去该年死亡个体的数量的差值；另外从该种群年头的数量与该年年底的数量的差值，当趋于0时，即认为该群落的个体数量是稳定的，从而把问题的稳定性问题转化为求单目标的最优化问题建立模型；利用MATLAB对模型进行求得，得出当不考虑不确定性因素影响时要注射药物的雌性动物数量为276头，而当考虑了双胞胎和被重复注射这两个不确定性因素影响后，得到要注射药物的雌性动物数量为352头，其中有110头是被重复注射的。

Transplantation of motoneurons derived from MASH1-transfected mouse ES cells reconstitutes neural networks and improves motor function in hemiplegic mice.

ES细胞向神经细胞分化的研究有利于人们了解胚胎神经细胞发育的机制、发现ES细胞向神经细胞分化的关键调节基因；建立体外定向诱导神经细胞分化体系将为神经疾病治疗药物的筛选以及基因工程药物的开发等提供有用的材料；体外大量有功能的特定神经元的获得使神经再生医学正一步步从理论走向实践。

Identification of extensive phenotypic information to 6 pare cultures and detection of the mol% G+C ratio of the DNA to representative strains, showed that the examined bacteria belonged to a new morphovar of Acinetobacter junii, and was designated as Acinetobacter junii Morphovar Ⅰ. In addition, serotype, antibiotic sensitivity and pathogenicity of isolates were studied, the results showed that the 6 strains have the same K-antigen and O-antigen, there arc no obvious differences in sensitivity and resistance to used 37 antimicrobial agents between strains, and have strong pathogenicity to experimental stone bonder and Bastard halibut.

经对6株纯培养菌在形态特征、理化特性等方面较系统的表观分类学指征鉴定及代表菌株DNA中G+C mol%的测定，表明为琼氏不动杆菌的一个新形态型并定名为琼氏不动杆菌形态型Ⅰ(Acinetobacter junii morphovar Ⅰ)；同时，对该菌进行了血清型、对抗菌类药物的敏感性及致病作用等方面的试验，初步表明此6株菌具有同种的表面及同种的菌体抗原，对供试37种抗菌类药物在不同菌株间的敏感及耐药无明显差异，对供试石鲽及牙鲆均具有较强的致病作用。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。