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The invention relates to the isolation and preparation of an active fraction from plant Cuminum cyminum, its further purification and standardization as chemically defined entity with their intended use as drug bioavailability enhancer for the drugs belonging to therapeutic categories such as antimicrobial, antifungal, anti-viral, antitubercular, antileprosy, anti-inflammatory, antiarthritic, cardiovascular, antihistaminics, respiratory distress relieving drugs, immunosuppressants, anti-ulcerogenic, anti-cancer, CNS drugs, corticosteroids, nutraceuticals in compositions to be administered orally/parenterally, topically, inhalations, rectally, vaginally in human beings and/or veterinary conditions.

本发明涉及植物孜然芹中的一种活性级分的分离和制备,进一步的纯化以及它作为化学确定实体的标准化,和它作为治疗类药物的生物利用率增强剂的特定用途,这类药物包括如抗微生物剂、抗真菌剂、抗病毒剂、抗结核药、抗麻风病药、抗炎药、抗关节炎药、心血管类药、抗组胺药、呼吸窘迫缓解药、免疫抑制剂、抗溃疡药、抗癌药、CNS药、皮质甾类药、营养制品,它们以组合物的形式通过口服/肠胃外,局部,吸入直肠,阴道施用于人和/或兽医学病症中。

A study in press in the Journal of Clinical Psychopharmacology notes that women treated with SSRIs during late pregnancy are more likely to give birth to small and premature babies. A study published in the October 2009 Archives of Pediatric and Adolescent Medicine suggests that women taking SSRIs are twice as likely to have preterm births as compared with the general population and that their babies are more likely to spend time in the neonatal intensive care unit.

在《临床精神药理学杂志》上发表的一项研究指出,怀孕晚期利用 SSRI 类药物治病的妇女更有可能生下体型小和早产的婴儿。2009年10月发表在《儿科与青少年医学文献》上的一项研究表明:服用 SSRI 类药物的妇女早产的可能性是普通人群的两倍,她们的婴儿更有可能要在新生儿重症监护病房度过一段时间。

The average recoveries were 60.2%~125% and 64.5%~126% for the drugs in plasma and urine except those of perphenazine, thioridazine and chloropromazine in plasma were 37.6%~57.5%, 36.3%~48.3%, 52.4%~67.4%, respectively; trazodone and diazepam in urine were 100%~142% and 108%~177%, respectively. The relative standard deviations of all the drugs in plasma and urine were within 0.8%~26% and 2.6%~18%(n=6), respectively. The detection limits of the 4 barbitals ranged from 20 to 100 mg/L and those of the other drugs ranged from 0.05 to 2.0 mg/L.

血浆样品中待测组分的加标回收率除了奋乃静、硫利哒嗪和氯丙嗪的分别为37.6%~57.5%, 36.3%~48.3%和52.4%~67.4%外,尿液样品中待测组分的加标回收率除了曲唑酮和地西泮的分别为100%~142%和108%~177%外,血浆和尿液中其余待测组分的加标回收率分别为60.2%~125%和64.5%~126%,相对标准偏差分别为0.8%~26%和2.6%~18%(n=6);除了巴比妥类药物的检出限为20~100 mg/L外,其余药物的检出限均为0.05~2.0 mg/L。

Conversely, in our experience,3 after 2 months of CRT, only 30%(48/162) of patients with AF presented with BVP 85% despite implementation of a rigorous rate-control protocol (rate-lowering drugs plus ventricular rate regularisation and trigger mode).

AF患者群中,如果包含这20例&临床行为&类似SR的患者,那么会使得任何结果都变得混淆。考虑到负性心率药物的低使用率和未使用调节心律的药物,报告中涉及的AF人群中的高BVP百分比是惊人的。对快速性心率失常患者恢复正常心室率这一点尤为重要。

Based on the analysis of international circumstances, it points out that though foreign countries are having the lead of chemical medicines, the variations of human diseases and the changes in people's senses of health.

通过对国际环境分析,指出虽然国外天然药物的研发水平领先于我们,但由于化学药物的缺陷、人类疾病谱的变化以及人们健康观念的改变,我国中成药仍有较大的发展空间,特别是复方中成药有较大的优势。

Quite a few terminally晚期地,致命地ill patients would often like their doctors to administer lethal drugs注射致命药物 to them to be relieved of suffering; there are also some of their families who would prefer that doctors withdraw any life-prolonging treatment撤销延长生命性质的治疗since there is no hope of effecting an ultimate cure.

相当一部分绝症末期的病人通常想让他们的医生为他们注射致命药物,将他们从痛苦中解救出来。同时,还有一些病人家属向医生提出,撤销延长病人生命性质的治疗,因为对其最终的治疗并不抱什么希望。

There are differences in the expression of Adrenal glands proteins in the hyperthyroidism rats with hyperactivity of liver-YANG after treatment with PGQY, and the cure mechanism of PGQY may associate with antioxygen, accommodation the functions of peripheral sympathetic nerve and adrenal medullae ,regulation of enzyme concerned with energy metabolism through these 10 identified protein spots.

平肝潜阳药物治疗后的甲亢肝阳上亢证大鼠肾上腺蛋白质的表达上具有差异,平肝潜阳药物的作用机制可能与所鉴定的这10个蛋白质的抗氧化、调节交感-肾上腺髓质功能及影响能量代谢相关酶等作用有关。

Results: The four linear calibration curves were obtained over the range 0.025μgml^(-1) to 3.2μgml^(-1) of amphetamines (amphetamine, methamphetamine, MDMA, MDA) in urine (r=0.9977-0.9998). The recoveries of the assay were better under different concentrations and the lowest concentration of detection reached the level of nanogram.

结果:4种苯丙胺类药物在尿药浓度为0.025-3.2μgml^(-1)范围内标准曲线的线性关系良好(r=0.9977-。09998);高、中、低3种浓度各标准药物的回收率较高;日内、日间精密度的BSD基本符合小于10%的要求;最低检测浓度能够达到纳克级,具有较高的灵敏度。

objective to study the effects of rabdosiae serrae compound preparation on staphylococcus aureus biofilm.methods minimal inhibitory coh centration were tested by doubling dilution,and simulate s.aureus biofilm in vitro be improved brown plate method.the effects of r.serrae compound preparation in different mic on s.aureus biofilm were determined and confirmed by scanning electronic microscope.single layer cells of human floss film were used to test the toxic effects of the compoud preparation.results the mic of s.serrae compound to s.aureus was 128?

目的 研究溪黄草复方对金黄色葡萄球菌生物膜的影响。方法采用试管二倍稀释法测定药物的最低抑菌浓度,用brown平板改良法体外复制金黄色葡萄球菌生物膜模型,并检测溪黄草复方的不同mic浓度对金黄色葡萄球菌生物膜的影响,扫描电镜确认。采用人绒毛膜单层细胞体外培养检测受试药物的毒性作用。结果溪黄草复方对金黄色葡萄球菌的mic值为128?

Take Kunming male small rat 40, random cent is 4 groups, be spent according to the strut of small rat ear of xylene be caused by and ply differs those who analyse every groups of medicaments to fight phlogistic action; to take Wistar male bandicoot 40, random cent is 4 groups, according to phosphoric acid constituent amine is opposite ply of area of splash of cutaneous of the back after bandicoot of Yiwen La Zaomo, skin and skin are deliquescent the convergent effect that the optical density influence at acetone solution analyses every groups of medicaments.

取昆明雄性小鼠40只,随机分为4组,根据二甲苯所致的小鼠耳肿胀度和厚度差分析每组药物的抗炎功能;取Wistar雄性大鼠40只,随机分为4组,根据磷酸组织胺对伊文氏蓝造模大鼠后背皮肤的色斑面积、皮肤厚度和皮肤溶解于丙酮溶液的光密度影响分析每组药物的收敛功能。

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Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

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