药物的

Furthermore, the roles that veratridine plays in the emergence of the parabolic bursting, namely inhibiting the inactivation of sodium channels and eliciting the slow sodium influx, are clarified.

进而阐明了藜芦碱引起这一放电形式所起的作用，即抑制钠通道失活引发慢变钠内流。这种利用非线性动力学理论的分析方法可能会为分析药物的药物动力学提供一种新的途径。

Therefore, selection of patients who might benefit from antiplatelet therapy other than aspirin is important.

因此，对于除阿司匹林之外的抗血小板药物药物的应用，选择合适的患者是重要的。

Clearly, new modes of therapy are necessary. The crux is to increase the specificity of cytotoxic drugs.

因此在不降低药效的情况下尽量减少化疗药物的剂量、提高抗白血病药物的选择性就成了问题的关键。

Despite the poor response rates in the chemotherapy-alone group, Dr. Burstein believes that metronomic chemotherapy combined with bevacizumab should be investigated further, given the tolerability of the agents and the preclinical rationale for efficacy. When asked why cyclophosphamide and methotrexate were selected for metronomic chemotherapy, he observed that many patients in this setting are already somewhat chemotherapy-resistant.

尽管只接受化学疗法的病患反应率很低，Burstein医师相信节律性化学疗法加上bevacizumab应该进一步研究，因为该药物的耐受性良好，而且临床前实验认为是有效的；当被问到为什么选择cyclophosphamide与methotrexate作为节律性化学疗法的药物，他观察发现，许多病患在这个时候已经对许多化学疗法产生抗药性。

Despite the poor response rates in the chemotherapy-alone group, Dr. Burstein believes that metronomic chemotherapy combined with bevacizumab should be investigated further, given the tolerability of the agents and the preclinical rationale for efficacy. When asked why cyclophosphamide and methotrexate were selected for metronomic chemotherapy, he observed that many patients in this setting are already somewhat chemotherapy-resistant.

尽管只接受化学疗法的病患反应率很低，Burstein医师相信节律性化学疗法加上bevacizumab应该进一步研究，因为该药物的耐受性良好，而且临床前实验认为是有效的；当被问到为什麼选择cyclophosphamide与methotrexate作为节律性化学疗法的药物，他观察发现，许多病患在这个时候已经对许多化学疗法产生抗药性。

He says artesunate and mefloquine could have a use in places like Eastern eastern Africa where there are high level levels of resistance to several drugs. The Drugs for Neglective Disease Neglected Diseases Initiative began in two thousand three. It was established by the * institute Pasteur Institute and Doctors with Without Borders along with form four publicly supported research organizations.

目前，在非洲，有两种重要的使用青蒿琥酯与其他药物的治疗方法，他说青蒿琥酯与甲氟喹可以用于像东非那样有高抗药作用的地区。2003年被忽略疾病研发药物计划开始，由Pasteur研究所与无国界医生及其他四个公共支持的研究组织成立。

Androstenedione and dehydroepiandrosterone as a new steroid material attracts people's attention because of the shortage of diosgenin resource and successful synthesis of AD by degradation of sterols. The followings were included in this thesis: 1. 24 new oxime-ether and oxime-ester compounds from AD were synthesized by cleavage of A-ring through NaIO_4/KMnO_4 oxidation, ring closure by amination, oximation with hydroxylaminechloride in C-17 position.

甾体药物的合成原料一般为薯蓣皂素、剑麻皂素、番麻皂素等，随着薯蓣资源日渐枯竭，使得甾体药物工业不得不寻求新的原料，而微生物降解胆固醇和植物甾醇合成雄烯二酮获得成功，使得AD成为新兴的甾体原料吸引了人们的注意。

Drug absorption is determined by physicochemical properties of drugs, their formulations, and routes of administration.

药物的吸收是由药物的理化性质、药剂的配方及给药途径所决定的。

Thermal analysis technique is widely used in preformulation work with advantages of simplicity and effectiveness.

地红霉素肠溶制剂，特别是微丸，应包制隔离衣以提高药物的稳定性；热分析技术应用于药物与辅料相容性的研究，操作简便，不需特殊制样，是处方前研究的有效的技术手段。

"That can cause real problems, because that remaining 10 percent of patients — who may have look-alike conditions such as multi-system atrophy or progressive supranuclear palsy — end up getting treated with Parkinson's drugs," Dr.

&这确实是个问题，因为剩下10％的病人－他们可能患有诸如多系统萎缩或进行性核上性麻痹的疾病－最后则接受帕金森病药物的治疗，&Beal博士说，&这些药物也许能起一时之效，但同时，他们并未能接受最适宜的治疗。&

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。