药物的

Plasma protein binding influences distribution and the apparent relationship between pharmacologic activity and total plasma drug concentration.

血浆蛋白的结合作用会影响药物的分布，并影响药理活性和总血浆药物浓度间的表观关系。

According to some research on medicines, such as innovations of medicines with nano-technology, medical applications of nano-materials and develop-pments of nano-scale diagnostical and analytical agents, several applications of nanotechnology in pharmic research are reviewed.

从纳米技术对现有药物的改造、纳米材料的药用研究和纳米诊断及分析试剂等药物研究领域出发，综述了纳米技术在药学研究中的若干应用。

A pure and single K+ current of ultrarapid delayed rectifier K+ current or transient outware K+ current is respectively expressed on Xenopus Oocytes. This is a moderm pharmacological model for evaluation class Ⅲ antiarrhythmiv durgs, overcomes many defcts such as lacking human fresh cardiac muscle cells as material and co-expression of many currents on cell membrane. A new compound A1998 from Ocean material is evaluated in this model for class Ⅲ antiarrhythmic functions.

5和Kv4.2cDNA转录为mRNA，然后将其分别注入蟾蜍卵母细胞上：在蟾蜍卵母细胞上分别获得纯净、单一的超速延迟性整流钾电流(Ikur，ultrarapid delayed rectifier K+current)和瞬间外向钾电流(Ito，transient outward K+current)表达，克服以往在筛选评价抗心律失常药物时，人新鲜心肌细胞取材困难、多种电流在细胞膜表面共同表达等缺点，从而建立评价Ⅲ类抗心律失常药物的先进药理模型，并筛选具有Ⅲ类抗心律失常药理作用的新化合物A1998。

Cohen and colleagues identified a previously uncharacterized gene, called txr1, whose increased expression in prostate cancer cells confers resistance to taxane drugs.

前列腺癌细胞中这个基因表达的增加会导致对taxane药物的抗性。Taxanes是一类广泛使用的化疗药物，商品名为docetaxel和paclitaxel。

On the other hand, the intensity of ultrasound stated, percutem transit dose of drug could be increased along with the time at the range of 10 min to 30 min. However, if it was given ultrasound over 40min, percutem transit dose of drug would be reduced significantly. Therefore, it was supposed that skin temperature was increased during a long time of ultrasound, and the skin would be damnified.

超声强度一定时，超声时间由10分钟加长到30分钟时，药物的累积经皮渗透量增加，当超声时间增加到40分钟时，药物的经皮渗透量却明显减小，可能是由于超声时间加长后，使皮肤温度显著升高，对皮肤造成损伤所导致的结果。

You know the fact that the majority of the drugs and dosing, we talked about daily dosing of different drugs.

我们知道大多数药物的给药剂量，探讨了不同的药物的日给药剂量。

Furthermore, the degree of optical purity of pesticides is osculating with the degree of chiral intermediate.

手性药物的光学纯度高低直接和生产该药物的手性中间体的光学纯度密切相关。

So the chains generally buy the drug for less than Medicare reimburses , making the drug a profit center.

这样一来，中心购入药物的价格低于医疗保障的偿付，使该药物成为利润的制造中心。

The different doses of 7603 and8102(100,400 and 1000mg/kg,which are eqivalent to 10,40 and 100times of the prescribed human dose)were given to ICR mice on the 7—11days of gestation.In the number of resorbed fetuses,the number of livefetuses,fetal weight and congenital malformations there were no signifi-cant difference between the control mice and the mice recieved variousdoses of 7603,or 8102,except the dose of...

结果可见，从7603各剂量组和8102的100、400毫克/公斤剂量组未观察到药物对孕鼠体重增长、活胎率、吸收胎率、胎鼠体重和胎鼠畸形发生率的影响。8102 1000毫克/公斤组则由于药物的毒副作用产生活胎率下降，吸收胎率和骨骼畸形率增加，孕鼠体重增长缓慢。

Thirdly ,under 25 0.5 ,pharmacocinetics and residues of orally administered at single and multiple dose of furazolidonum (60mg/kg) were investigated in grass crap , concentration of furazolidonum in Tissues were measured using HPLC and processed with MILLEMNIUM32 work station. The plasma concentration-time data was analyzed with MCPKP practical pharmacokinetics software.

其三，在25±0.5℃水温条件下，按60mg／kg的剂量给平均体重为65±10g的草鱼单次和多次灌服呋喃唑酮，用高效液相色谱法检测用药后不同时间血浆、肝脏、肌肉、肾脏中药物浓度，采用MILLEMNIUM~(32)工作站处理原始数据，然后用MCPKP药代动力学软件处理药时数据，对药物的吸收、分布、消除及组织残留进行研究。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。