药物的

The genistein and glucuronidated genistein in plasma and in different tissues were detected by a high performance liquid chromatography ashy.

用反相高效液相色谱法测定不同时间大鼠血浆中原型药物、β-葡萄糖醛酸结合型药物及组织器官中药物的浓度。

Membrane affinity quantified by IAM and liposome/buffer systems was a more efficient predicator of α values than hydrophobicity from n-octanol/buffer system. Consequently, not only hydrophobic force but also attractive polar extra-interactions involved in the binding to IAM and liposomal membranes but not in an n-octanol phase, ascribed to the binding process within AM. The binding to ordered lipid membrane in the larger part determined drugs'binding to AM intracellular compositions, and the ordered phospholipid plasma membrane was a potential site for drugs'binding in AM.

脂质体／水系统和磷脂膜色谱所测定的膜亲和性比正辛醇／水系统的疏水性更好的预测巨噬细胞内药物的α值，因此包含在磷脂膜色谱中但并不体现在正辛醇／水系统中药物与磷脂膜之间的额外吸引性极性作用力对药物在细胞内结合有着重要贡献；药物与有序磷脂膜的结合在很大程度上决定着药物与巨噬细胞内成分的结合，有序磷脂分子膜可能是巨噬细胞内部潜在的结合部位。

In this paper,the chemical stability of streptomycin sulfateis studied by the method of raising temperature freely.

药物的化学稳定性是药物的一个性质，是衡量药物有效期及药物剂型、剂量的重要指标。

However, unobvious symptom of the early patients often results in an erroneous diagnosis, and so it is imperative to develop new techniques to diagnose various cancers at early stage.

在医学中，研究抗肿瘤、抗病毒药物分子与DNA的相互作用，可以阐述药物的抗癌活性的作用机理，了解疾病的发病机理，对于寻找副作用小、疗效好的抗癌药物，研究抗癌药物在生物体内治疗疾病本质具有重要意义。

This res ult provides the theoretical basis for the system of zero order release as well as how to control the release rate and the amount of drug release.

根据该模型还从理论上分析了两种限定条件下药物的释放特征：当DmDf时，释放速率变为常数，达到零级释放，其释放速率与药膜无关，这为零级释放缓释体系如何控制释放速率和药物释放量提供了理论依据：当Dm Df时，药物的释放速率与药膜中的释放系数、溶解度和药物的装填量有关，与包膜过程无关，其释放过程类似于混合药膜缓释体系。

Clinical therapy to skin lesion could be treatedby systematic or typical application while drug concentration in skin lesion should beknown in both conditions, such as the drug concentration in blood should be knownwhen the pathogenesis of skin disease is some systematic factor.

其中药物与受体之间的亲和力由药物的结构和理化性质决定，因此靶组织的药物浓度是调节药物药效作用的主要手段。

New antifungal agents have been developed over the past years based on the discovery of many new target sites of Candida albicands. For example, Echinocandins, aiming at the cell wall of Candida albicands, showed strong antifungal activities to fluconazole resistant candidas and fungal biofilm. Moreover, because β-glucan synthase does not exist on the cell membrane of mammalian cells, Echinocandins has a low toxicity and a promising clinical future. Though the mechanism of Histatin is not clear, it has strong activity not only on candida resistant of polyene and azole, but also to Candida parapsilosis, Candida krusei and Cry ptococcus neoformans. Berberine and Ocimum gratissimum L. were also found to have prominent anti-fungi activities.

近年来相继提出了许多抗白念珠菌药物作用的新靶点并成功开发出一些活性强大，疗效确切的抗真菌药，如以真菌细胞壁为靶点开发出棘白菌素类药物卡泊芬净、米卡芬净等，该类药物主要抑制β-葡聚糖合成酶，体外对氟康唑耐药的念珠菌属及真菌生物被膜表现出强大的抗菌活性，又由于β-葡聚糖合成酶在哺乳类动物细胞内不存在，故具有高效低毒的临床效果，是一极具前途的新型抗真菌药；以真菌细胞膜为靶点开发出Histatin类药物，虽然作用机制目前还不完全明了，但其作用不同于临床常用的多烯类和氮唑类，并已经发现Histatin5对两性霉素B和氮唑类耐药的念珠菌有效，并且对非白念珠菌如光滑念珠菌、克柔氏念株菌、隐球菌等也有杀灭作用；通过对植物药物的研究发现黄连素和丁香罗勒Ocimum gratissimum L。

Macrocyclic supramolecular drugs forming by macrocycle s with special structure and high selectivity according to their different purpose could play important parts in the drug-controlled releasing, chiral recognition, mimic enzyme, molecular switch, and so on, especially supramolecular drugs can help to improve solubility, bioavailability of drugs and realize targeting when it encapsulates drugs.

具有独特的结构和高选择性的大环化合物所形成的大环类超分子药物可根据其目的不同在药物控制释放、手性识别、模拟酶、分子开关等方面起着重要作用，能大大改善药物的溶解度、生物利用度及实现靶向作用等，因此大环超分子药物为化学药物治疗提供了新的推动力。

The rationals of anti-angiogenesis are the following: the therapeutic target is tumor endothelial cells which are more genetically stable, more homogeneous, and with lower mutation rate; the anti-angiogenesis drugs can contact endothelial cells directly, with higher potency and lower drug barriers and side effects; the aim of anti-angiogenesis therapy is to block the oxygen and nutrition supply from vessels, instead of killing tumor r ells per se; the aim of anti-angiogenesis is to reduce tumor size instead of eradicate tumor which are different from traditional chemotherapy.

使用抗血管新生疗法根据的理论基础为以肿瘤血管的内皮细胞为治疗药物的攻击标的；肿瘤血管的内皮细胞基因比较稳定、同质性高、而且突变率低；投与的药物可以直接接触内皮细胞，减少投与药物屏障，因此增加有效投与药物的能力及减少药物副作用；以截断供应肿瘤氧气养分的血管为目标：以减小肿瘤的体积大小为目的，与传统化学疗法以根除肿瘤的目标不同。

For the long time, the herbalist doctor prescripts through experience, as for the composition of medicines, how the body processes, the role of medicines and treatment of any links between the problems which are often not very clear.

麻烦好心人帮忙翻译长期以来，中药多以经验给药，至于药物中哪些成分起作用、药物的体内过程如何、药物成分与治疗作用之间有什么联系等问题常常

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失