药物的

To facilitate the applications of biologically functional protein in drug design, it is necessary to have a thorough understanding of their conformations and their interactions with the receptors. NMR spectroscopy has the unique ability to retrieve information about 3D structures of proteins and their interactions with the target proteins in solution. Many NMR techniques have been used to study a number of pharmaceutically important proteins and characterize their interactions with the targets. In this review, we will introduce these NMR methods and show how to utilize them for protein drug design.

为了设计具有生物功能性的蛋白质来当作药物，我们必须对其蛋白质结构与其受体在结合时的作用有完整清楚的了解，而核磁共振光谱具有独特的能力，可以获得溶液状态下蛋白质结构以及蛋白质与标的蛋白质交互作用间的资讯，目前已有许多核磁共振光谱技术运用到蛋白质药物的研究，并确认它们与其标的蛋白质间的作用模式，笔者将在本文中介绍这些技术，以及如何运用它们来获取重要资讯，俾设计蛋白质药物。

Body massindex, preoperative blood pressure, ASA class, anesthetic duration,IV fluid administration, and use of analgesics and antiemeticsin the postanesthetic care unit were not different in subjectswho demonstrated OH compared with those with a normotensiveresponse.

血压正常组与 OH 组在健康指数，术前血压， ASA 评分，麻醉过程，静脉补液和镇痛药物以及麻醉后抗呕吐药物的使用方面没有差异。

Basing on the result of preformulation, the transdermal transit cumulate dose chosen as index, the effect of transdermal permeability of OXA by HPMC and sodium hyaluronate was investigated.

实验结果显示，棕榈酸异丙酯对四种药物的体外经皮渗透性均具有促进作用，尤其是对亲脂性药物促渗作用尤为显著。

Conclutions Topotecan is an effective remedy for treatment of small cell lung cancer, both single topotecan and combined regimen has the same effect as the traditional first-line regimen, though myelo-suppression such as leucopenia and thrombopenia is more sever, the adverse effect is tolerated. Though it has been recommended as second-line agent for chemo-therapy sensitive small cell lung cancer, there needs more clinical studies to verify its role in first-line.

结论拓扑替康是在小细胞肺癌的治疗中有确切临床疗效的药物，无论是单药还是与其他药物的联合用药均具有与当前一线经典方案相当的疗效，虽具有相对高的致白细胞和血小板下降的骨髓毒性，但毒副作用可耐受，已经被认为是治疗对化疗敏感的小细胞肺癌患者的二线推荐药物，但是作为一线用药仍然需要更多的临床证据来证实。

This Paper dis- cusses the ADR and safety evaluation through the "Aristolochic Acid affair".

本文从减肥药&马兜铃酸事件&来探讨了我国天然药物的不良反应和药物安全性评价。

Shintaro was detoxified without complications from two anticonvulsant medications he had been taking since he was three years old.

Shintaro终于从抗癫痫药物的控制下摆脱出来，而这些药物从他3岁开始就一直伴随着他。

Response rate to a combination of drugs is higher than that to a single drug, but survival is not improved and toxicity is increased.

组合药物的有效率大于单一药物，但生存期并没有延长，且毒性增加。

The first thing that happened was that the grains protected the B-subunit from being broken down in the stomach, thus overcoming one of the regular bugbears of protein-based drugs: that they cannot be given by mouth, because they will be digested.

首先，谷类粮食在胃中保护了B亚单位被直接消化，因此在传统上一直困扰蛋白质药物的一大难题得到解决，蛋白质药物会在胃中被消化往往不能直接口服。

The first thing that happened was that the grains protected the B-subunit from being broken down in the stomach, thus overcoming one of the regular bugbears of protein-based drugs: that they cannot be given by mouth, because they will be digested.

首先，谷类粮食在胃中保护了B亚单位被直接消化，因此使传统上一直困扰蛋白质药物的一大难题--蛋白质药物会在胃中被消化往往不能直接口服--得到解决。

The daily drug cost of non_bz hypnotics was higher than that of bz hypnotics.

非苯二氮卓类药物的日用金额一般都高于苯二氮卓类药物。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失