药物的

A developmental focus was placed upon the intermediates of the drug such as cephalosporin,antihypertensive,antilipemic,antiulcer,antineoplastic,antiviral,antineuralgic,vitamin and amino acid.

重点发展第二、三、四代头孢菌素中间体、第三、四代喹诺酮类药物中间体、新型抗高血压药物中间体、新型抗高血脂药物中间体、抗溃疡药物中间体、抗癌药及抗病毒药物的中间体、中枢神经药物中间体、手性药物中间体、维生素及各种氨基酸。

The result demonstrated that concentration of NFLX in Artemia can achieve its peak value after 8h and it increased with increasing of the doses of NFLX in water, the doses had a little influence on the peaking time.

结果表明，卤虫体内的药物含量在8小时内达到最高；体长相同的卤虫在不同的药物浓度下强化，其体内药物含量随着药物浓度的增加而增加；药物浓度对卤虫体内药物的达峰时间影响较小。

The first aim of this study is to clarify whether that polymorphisms of the genes that encode these enzymes associates with the TB drugs-induced adverse reactions. Furthermore, since tuberculosis patients are always administrated with multiple TB drugs, it is hard to distinguish which TB drug caused these adverse reactions.

本研究从结核药物过敏病患代谢酵素基因多型性方面探讨与结核药物过敏反应发生的相关性；此外，由於结核病患通常同时接受多种结核药物的治疗，导致难以判断是其中何种药物引起不良反应，本研究另一目标即为建立一T细胞体外培养系统，用於判断何种药物引起不良反应的产生。

Methods: 126 patients who applied analgetic entered the study and radomized to two treatment groups :Fluoxetine group (20mg/d) and Imipramine group (250mg/d),then studied after three weeks in three aspects of antidepressant, curative effect,pain affectability and side reaction.

对126例患者随机分组，全部患者在不受干扰，继续常规应用止痛药物的同时，进行抗抑郁药物辅助性干预治疗，抗抑郁药物选择5-羟色胺再摄取抑制剂氟西汀20mg/d和三环类抗抑郁药物氯丙咪嗪250mg/d口服，分别于服药当日及服药后3周进行相关各项指标的评定、比较。

The aim of the study is to understand and familiarized with the internal organ function and drugs classification in this chapt;master the common characteristics, pharmacological effects, mechanisms of action, clinical uses and adverse

学习导航：作用与内脏系统的药物包括28-34章；熟悉与本章药物相关的内脏器官的功能及药物的分类；掌握每一类药物作用的共性、代表药物的药理作用与机制、临床应用与主要不良反应。

Dr. Kiser and colleagues describe a temperature and pH sensitie polymer that was chosen as a potential bioresponsie microbicidal ehicle engineered to gie semen-triggered drug release and efficient coating and retention prior to intercourse.

Kiser博士及其同事描述说，一种对温度和pH敏感的聚合物用作杀菌药物的载体，设计成通过精子触发药物释放，并且在性交前能有效地包被药物和保持药物活性。

It is especially discussed that the principle, operation process and effects of the operation parameters on the characteristic of the products when the hydrophilic drug micronized with the supercritical assisted atomization which is an improvement on the supercritical anti-solvent technology. It is also introduced that the embedment of hydrophobic drug into biodegradable materials with the use of surfactant as well as the effect of different molecular weight of carrier and different ratio of complex carrier on the characteristic of products is made. It is pointed out that the use of surfactant will improve the micronization of microparticles of the hydrophobic drugs.

在药物微粉化方面，着重介绍了超临界辅助原子化法对水溶性药物的处理，包括该方法的原理、操作方法以及操作参数对产品性能的影响，证明该方法用于改善水溶性药物的微粉化具有良好的效果；在制备药物微球方面，重点介绍了不同操作条件和不同分子质量的载体、不同配比的复合载体对药物微球性能的影响以及表面活性剂在亲脂性及离子型药物微球制备中的应用，指出添加表面活性剂将更有利于得到该类药物的微球。

In the preformulation study, the ultraviolet spectrum and HPLC methods for the assay of α-asarone were established firstly and then the physicochemical properties, especially the octanol/water partition coefficient and the solubility in various solvent systems such as alcohol, PEG 400, IPM, octanol were examined. The prediction permeability was then compared with actual transdermal parameters obtained from the in-vitro diffusion study , and feasibility of drug transdermal absorption was then analyzed.

在制剂开发的处方前研究工作中，首先建立了α-细辛醚的紫外及HPLC分析方法，测定了药物的油水分配系数及在生理盐水、各系列浓度的乙醇、PEG400、肉豆蔻酸异丙酯、正辛醇等溶媒中溶解度；其次，确立了药物体外经皮渗透研究的方法，并考察溶媒及促渗剂(乙醇、丙二醇、肉豆蔻酸异丙酯等)对药物体外经皮渗透性能的影响，计算药物经皮渗透的各参数，根据药物的药物动力学参数，分析了药物经皮吸收的可行性。

The US Food and Drug Administration has issued an alert that some patients may experience severe and possibly incapacitating musculoskeletal pain while taking bisphosphonates, notes Business Week , carrying an Associated Press wire story."Although severe musculoskeletal pain is included in the prescribing information for all bisphosphonates, the association between bisphosphonates and severe musculoskeletal pain may be overlooked by healthcare professionals, delaying diagnosis, prolonging pain and/or impairment, and necessitating the use of analgesics," the FDA says in a statement on its Web site.

经济周刊相关报社火线故事报导，美国食品药物管理局已经发出一项警讯，部分病患在使用双磷酸盐药物时，可能会发生严重与可能是使肌肉无力的肌肉骨骼疼痛；FDA在网站上的一项声明指出，虽然严重肌肉骨骼疼痛包含在双磷酸盐药物的处方资讯中，但双磷酸盐药物与严重肌肉骨骼疼痛之间的关连可能被健康照护者所轻忽，因此造成延迟诊断、延长疼痛以及或是损伤时间，并且使得病患需要使用止痛药物。

The US Food and Drug Administration has issued an alert that some patients may experience severe and possibly incapacitating musculoskeletal pain while taking bisphosphonates, notes Business Week , carrying an Associated Press wire story."Although severe musculoskeletal pain is included in the prescribing information for all bisphosphonates, the association between bisphosphonates and severe musculoskeletal pain may be overlooked by healthcare professionals, delaying diagnosis, prolonging pain and/or impairment, and necessitating the use of analgesics," the FDA says in a statement on its Web site.

经济周刊相关报社火线故事报导，美国食品药物管理局已经发出一项警讯，部分病患在使用双磷酸盐药物时，可能会发生严重与可能是使肌肉无力的肌肉骨骼疼痛；FDA在网站上的一项声明指出，虽然严重肌肉骨骼疼痛包含在双磷酸盐药物的处方信息中，但双磷酸盐药物与严重肌肉骨骼疼痛之间的关连可能被健康照护者所轻忽，因此造成延迟诊断、延长疼痛以及或是损伤时间，并且使得病患需要使用止痛药物。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失