药物治疗

Treating group A,36 cases,combine used corticosteroid drug use in nasal cavity (Fluticasone Propionate Nasal Spray)、secretion expellant、chinese patent medicine (Nasosinusitis Relieving Oral Liquid) in the perioperative treatment of endoscopic sinus surgery .

治疗组A，36例，联合使用鼻腔局部皮质类固醇药物、粘液溶解排除剂、中成药于鼻内镜鼻窦手术的围手术期治疗；治疗组B，106例，使用其中任意两种；治疗组C，123例，使用其中任意一种；组D为对照组，39例，不使用以上药物。

Dr. Fassler stressed that many individuals with ADHD are still not being diagnosed or receiving treatment, and parents have many questions about the most appropriate care for their child, which the guide was designed to address. Subcommittee member Adelaide Robb, MD, added that the guide is written in an easy-to-understand question-and-answer format. In addition to unraveling the complexities of ADHD medications, the guide also discusses other ADHD issues such as stimulant medication and addiction, school and ADHD, behavioral treatments, and nonproven treatments. It concludes with lists of recommended reading for children and adults.

Fassler医师强调，许多ADHD病患仍未被诊断或接受治疗，双亲对其小孩的最适当治疗存有疑虑，而这些是此一规范所要表达的；小组委员会成员Adelaide Robb医师指出，该规范是以简单易懂的问答形式撰写，为了阐明复杂的ADHD药物，该规范也讨论其它有关ADHD的议题，如刺激性药物与加成作用、学校与ADHD、行为治疗，以及一些尚未经证实的治疗；结论列出一些提供给小孩和成人的建议读物。

The pathological factors and mechanisms of CM resulting in insomnia are a lot of causes and varied, such as abnormal climatic changes, pestilence infection, seven-emotional-factors stimulation, dietary ignorance, overstrain and stress, functional disorders of yin and yang, qi and blood, and zang-fu organs.

中西医学治疗失眠最主要在於消除导致失眠的各种因素，但仍以药物疗法为主；西医学的失眠药物以安眠药或助眠或抗失眠药物为主，而中医学的失眠药物则以辨证论治的安神宁心为主，在治疗上应当以补正虚、去邪扰、以及调整阴阳、气血、脏腑功能平衡为原则。

It is a leading publication in psychopharmacology offering a wide range of articles reporting on clinical trials and studies,side effects,drug interactions,overdose management, pharmacogenetics,pharmacokinetics,and psychiatric effects of non-psychiatric drugs.

这是一份在精神药理学领域的领头刊物，它刊登文章的范围很广，包括临床试验和研究、副作用、药物相互作用、过量管理、遗传药理学、药物动力学以及非治疗精神病药物的精神病治疗效果等。

Methods 160 patients with hypodynamia and vertigo after injected the antibiotics,expand the afferent medicine and other the medicine(expel the medicine with the result that high blood pressure,low blood pressure,low blood sugar but appear the above symptom),were randomly divided into two groups:one of the normal regulations treatment(glucose +the vitaminc+vitamin B6),,the other group use the Watersoluble vitamin,contrast to observe the efficacy of the treatment after a week.

摘 要］目的：探讨用水溶性维生素治疗药源性乏力、眩晕疗效。方法：选择160例注射抗生素、扩血管药及其他药物后出现乏力、眩晕症状的患者(排除药物所致高血压、低血压、低血糖而出现以上症状)。随机分为二组：一组常规治疗(葡萄糖+维生素C+维生素B6)；二组用水溶性维生素治疗，治疗时间为一周，对比观察其疗效。

objective to evaluate the efficacy of water soluble vitamin for the treatment of hypodynamia and vertigo of drug induced.methods 160 patients with hypodynamia and vertigo after injected the antibiotics,expand the afferent medicine and other the medicine(expel the medicine with the result that high blood pressure,low blood pressure,low blood sugar but appear the above symptom),were randomly divided into two groups:one of the normal regulations treatment(glucose +the vitaminc+vitamin b6),,the other group use the water soluble vitamin,contrast to observe the efficacy of the treatment after a week.results the effect of therapy was obviously better than that of the control group(χ2=4.44,p.05).conclusion the water soluble vitamin can improve the hypodynamia and vertigo of drug induced symptom better.

摘 要］目的：探讨用水溶性维生素治疗药源性乏力、眩晕疗效。方法：选择160例注射抗生素、扩血管药及其他药物后出现乏力、眩晕症状的患者(排除药物所致高血压、低血压、低血糖而出现以上症状)。随机分为二组：一组常规治疗(葡萄糖+维生素c+维生素b6)；二组用水溶性维生素治疗，治疗时间为一周，对比观察其疗效。结果：观察组治疗有效率与对照组比较差异有统计学意义(χ2=4.44，p.05)。结论：水溶性维生素能更好地改善药源性乏力、眩晕症状。

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

Usage: useful for pharmaceutical intermediate,especially useful for intermediate of synthesis aids inhibitor and high temperature resistant resins and metallocen catalyst for olefine polymerization.

用途：用作各种医药合成中间体，特别是抗艾兹病药物，治疗糖脲病药物以及治疗心律不齐病药物的中间体以及烯烃聚合用金属茂络合物催化剂配位体和透明的耐热性树脂原料。

Conclutions Topotecan is an effective remedy for treatment of small cell lung cancer, both single topotecan and combined regimen has the same effect as the traditional first-line regimen, though myelo-suppression such as leucopenia and thrombopenia is more sever, the adverse effect is tolerated. Though it has been recommended as second-line agent for chemo-therapy sensitive small cell lung cancer, there needs more clinical studies to verify its role in first-line.

结论拓扑替康是在小细胞肺癌的治疗中有确切临床疗效的药物，无论是单药还是与其他药物的联合用药均具有与当前一线经典方案相当的疗效，虽具有相对高的致白细胞和血小板下降的骨髓毒性，但毒副作用可耐受，已经被认为是治疗对化疗敏感的小细胞肺癌患者的二线推荐药物，但是作为一线用药仍然需要更多的临床证据来证实。

Antibody-dependent enhancement of dengue virus infection and the unclear pathogenesis mechanism hamper the prevention and treatment of the disease. No efficient preventative and therapeutic drugs are available now, but much progress has been made in the last few years in the drug prevention and therapy of dengue fever.

抗体依赖的感染增强作用以及对病毒致病机制的尚未完全阐明均阻碍了登革热预防与治疗药物的发展应用，目前并无临床可用的特异性预防与治疗药物，但近年来，随着登革热发病机制以及治疗方法研究的不断深入，在登革热药物防治方面的研究有了新进展。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新