药物治疗

Along with deep scientific research and continual development of pharmacogenetics and pharmacogenomics,the new era of individual pharmacotherapy will come true in the future.

随着遗传药理学和药物基因组学的深入研究和不断发展，个体化药物治疗的新时代即将到来。

William Bennett, MD, from the Legacy Good Samaritan Hospital, in Portland, Oregon, remarked in a comment to Medscape that the bulletin does a good job of raising awareness of the need to adjust medication doses when treating patients with CKD."It's a call to be a responsible prescriber," he said. He stressed that practitioners need to take into account why they are treating their patient with the drug they have chosen.

奥勒冈州波特兰Legacy Good Samaritan医院William Bennett医师在一项评论中向Medscape表示，该期刊唤起大家对於CKD病患使用药物的剂量必须经过调整的注意，他表示，必须做个有责任的处方医师，他强调，执业者必须将为什麼使用这些药物治疗这些病患列入考量。

Stefan Schreiber of Christian Albrechts Uniersity in Kiel, Germany, 48 percent of patients who showed an early response to the drug were still in remission in the 26th week after staying on the drug.

德国基尔大学Stefan Schreiber博士领衔的研究组认为，早期对药物有反应的患者中，48%的患者在药物治疗后第26周后仍处于缓解期。

However, despite the successes of the sulfa drugs, most infectious diseases still were not under chemical control.

然而，尽管磺胺药物已经成功，但大多数传染病仍然无法进行化学药物治疗。

There are many studies concerning that the genetic variations of UGT1A1 are associated with unconjugated hyperbilirubinemia, and irinotecan-induced adverse drug reactions; however, there is no studies to investigate the association of liver injury during antituberculosis therapy and UGT1A1 genetic variations.

UGT1A1基因变异与未结合型高胆红素血症，及irinotecan诱发之药物不良反应有相关，但尚未有UGT1A1基因变异的族群，在接受抗结核药物治疗期间发生肝损伤之研究。

The growth inhibiting rate of T24 cell lines were detected by MTT methods, apoptosis of cells were detected by flow cytometry, the mechanism of apoptosis was analyzed by detecting the protein expression of Bcl-2, Bax, Caspase-9, Caspase-3 and cytoplastic protein Cytochrome C. 4 We injected live T24 cells into the subcutaneous space of nude mice and successfully built up the animal model of bladder carcinoma. The effect of CS-PAA-EPI polymer magnetic microspheres targeting chemotherapy was investigated by HE staining, TUNEL ,tumor weight and volume inhibition rate. Results: 1 TEM revealed that the CS-PAA polymer magnetic microspheres were regular spherical shape,the average diameter was 80nm in dry condition. By controlling the pH value of the medium,polymers had positive or negative zeta potential. VSM showed the CS-PAA polymer magnetic microspheres had superparamagnetic. The diameter of CS-PAA-EPI polymer magnetic microspheres were 200nm in solution by DLS examining,the embedding ratio was 20%,the EPI loading rate was 15%, which was higer than reported in other articles. 2 Raw eye observation found that the rat"s bladder of treatment group was brown color,which meaned the aggregation of iron particles, compared with the control group, iron stain found iron particles were assembled in rat"s bladder of the treatment group, the amount of iron particles in liver and spleen were less obviously.

研究结果：1合成的CS-PAA磁性聚合物微球呈球形，大小均一，TEM测定其干态下粒径为80nm左右，磁化曲线证实具有超顺磁性，具有一定的PH敏感性，固载表柔比星后，水溶液性状稳定，无沉淀物，DLS测定直径约200nm左右，测定载药率为15％，较文献报道高，包封率为20％。2肉眼观察试验组大鼠膀胱表面呈褐色，可见大量的Fe粒子聚集，普鲁士兰染色法显示，试验组大鼠膀胱壁内有大量的Fe粒子，分布至膀胱壁全层，与对照组大鼠相比，试验组大鼠的肝、脾内的Fe粒子聚集量明显降低；HPLC测定结果与Fe染色相同；高剂量磁性CS-PAA-EPI生理盐水组及单纯EPI生理盐水组均在给药后14天出现血肌酐和尿素氮的升高，其他组大鼠血生化指标没有明显变化。3MTT法发现，高、中、低剂量磁性CS-PAA-EPI生理盐水组在外加磁场的协同作用下杀伤T24细胞效应明显高于单纯的EPI生理盐水组，FCM发现试验药物组可引起明显的肿瘤细胞凋亡，试验药物治疗组细胞胞浆内出现了由线粒体释放出的细胞色素C，试验组细胞Bcl-2蛋白减少，Bax蛋白变化不明显，Caspase-3、Caspase-9蛋白受到了激活活化。4高、中、低剂量磁性CS-PAA-EPI生理盐水组的瘤重抑制率和瘤体积抑制率均明显高于单纯的EPI生理盐水组(P＜0.01)，其中高剂量组的抑制率最高。

Objective: To investigate the Changes of Adrenal glands Proteome Caused by traditional chinese medicine of pinggan-qianyang in the hyperthyroidism rats with hyperactivity of liver-YANG and further explore the cure mechanisms of PGQY Methods: Animal models were established by ip levo thyroxine (L-T4) and fuzi tang.

目的：观察平肝潜阳药物对甲亢肝阳上亢证大鼠肾上腺蛋白质表达的影响，为进一步探讨平肝潜阳药物治疗甲充肝阳上亢证作用机理提供依据。

Jinake has the synergic effect to chemical drugs in the treatment of cancer shch as malignant lymphadenoma.

金艾康具有对化学药物治疗肿瘤增效作用，其作用机理可能是逆转MDR，并能降低化学药物引起的如消化道反应与肢端麻木症状等毒副作用。

Myasthenic symptom was not clianged in one patient for whom radiotherapy had been standed before operation nor during the course of postoperative radiotherapy.

单次剂量1.8～2.0Gy的照射方式不会加重肌无力症状，但放疗中必须应用合理的抗胆碱酯酶药物，密切观察肌无力变化，及时调整药物治疗方案。

Results Through the antivirotic drugs,hormones,neurotrophic drug treatment and symptomatic treatment,12 cases were cured.

结果 通过抗病毒药物、激素、神经营养药物治疗和对症处理，12例治愈。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。