药物依赖性

Under the same concentration, tadalafil induce higher ratio of relation responses in the smooth muscles of CRF rabbit cavernosal strips, compared with papaverine and sodium nitroprussiate, with most significant difference occurring under the concentration indicators of 10-5 mol/L and 10-4 mol/L (P.01). Conclusions The effects of tadalafil on relaxation responses in CRF rabbit cavernosal strips highly depend on its concentration. The effect of tadalafil on relaxation responses in CRF rabbit cavernosal strips is better than that of papaverine and sodium nitroprussiate. Tadalafil may be an effective drug for treating CRF reduced erection dysfunction.

同一浓度下，他达拉非对慢性肾功能衰竭兔阴茎海绵体平滑肌舒张百分比与罂粟碱、硝普钠相比较，舒张百分比均大于罂粟碱和硝普钠，且在10~(-5)mol/L、10~(-4)mol/L浓度，他达拉非对慢性肾功能衰竭兔阴茎海绵体平滑肌舒张百分比，与罂粟碱、硝普钠相比较有显著性差异(P＜0.01)结论他达拉非对慢性肾功能衰竭兔阴茎海绵体平滑肌舒张反应的影响具有浓度依赖性，他达拉非对慢性肾功能衰竭兔阴茎海绵体平滑肌舒张反应的影响优于罂粟碱及硝普钠，他达拉非可能是治疗慢性肾功能衰竭性阴茎勃起功能障碍的理想药物。

Oral administration of this small molecule once daily for up to six weeks acts prophylactically or therapeutically, in a dose-dependent manner, to treat osteoporosis in ovariectomized rodents because of an isolated increase in bone formation.

口服这种小分子药物每天一次，持续6周，能起到预防或治疗去卵巢老鼠骨质疏松的效果，这种方法呈剂量依赖性。

In this investigation, TP could inhibit the ATPase's activity of P-gp in dose-dependent manner, indicating that TP exerted their modulation effect on MDR through inhibiting the ATPase activity of P-gp, and consequently interdicting the pumping function of P-gp on anti-cancer drug.

研究发现TP剂量依赖性的抑制ATPase活性，说明TP可以通过抑制P-gp糖蛋白的ATP酶活性的方式阻断P-gp糖蛋白对抗癌药物的溢出作用从而发挥其逆转MDR的作用。

Recently, to elucidate deeply the mechanisms of opiates dependence and to develop the novel medicine is an important direction.

深入探讨阿片类物质依赖性机制和开发新型药物仍是当今重要研究方向。

Results when treated with aloe-emodin or doxorubicin for 48h, with the increase of drug concentration, the growth inhibition rate increased.

结果 两药单独作用48 h对HepG2细胞的抑制率，随着药物浓度的增加均相应增加，呈剂量依赖性。

The compositions are useful in contraception and hormone replacement therapy and in the treatment and/or prevention of uterine myometrial fibroids, benign prostatic hypertrophy, benign and malignant neoplastic disease, dysfunctional bleeding, uterine leiomyomata, endometriosis, polycystic ovary syndrome, and carcinomas and adenocarcinomas of the pituitary, endometrium, kidney, ovary, breast, colon, and prostate and other hormone-dependent tumors, and in the preparation of medicaments useful therefor.

所述组合物也可用于避孕和激素替代治疗和治疗和/或预防子宫的子宫肌层纤维瘤、良性前列腺肥大、良性和恶性肿瘤性疾病、功能异常性出血、子宫肌瘤、子宫内膜异位、多囊卵巢综合征和垂体、子宫内膜、肾、卵巢、乳房、结肠和前列腺的癌和腺癌及其它激素依赖性肿瘤，以及用于制备对其有用的药物。

Results: The polyamine analogue BENS markedly inhibited the proliferation of B16-F1 cells in a dose-dependent manner.

结果：多胺类似物BENS能显著抑制B16-F1细胞增殖，抑制率呈药物浓度依赖性。

Recently, along with the related research on calcium channels, the function of voltage-dependent calcium channel in epileptics gradually draws researchers' attention, and then calcium antag...

近年来，随着对钙通道的研究的深入，尤其是电压依赖性钙通道在痫性活动中的作用越来越受到重视，钙拮抗剂也迅速成为抗癫痫药物的一个重要组成部分。

XIAP expression could not be affected by the apoptotie inductions mediated by death receptor and mitochondria pathway in both cell lines.

通过对肾癌组织和细胞的研究，提示抗凋亡的XIAP在肾癌组织中呈肿瘤进展依赖性增高、在抗凋亡的肾癌细胞高表达，在肾癌细胞抗凋亡机制中发挥重要的作用，影响肾癌对凋亡信号的敏感性，使肾癌细胞获得生存发展的优势，从而促进肾癌的进展，并产生对诱导凋亡药物的抵抗；应用基因克隆和Tet-Off基因可控性表达系统技术构建的肾癌细胞XIAP稳定表达细胞系，对深入研究XIAP在肾癌抗凋亡中的机制，具有实用意义。

You should be aware that prolonged use of laxatives may lead to dependence and may cause serious bowel problems.

你应该了解到长期使用帮助排泄的药物会导致身体对其依赖性也会造成严重的肠问题。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。